Tunable aggregation of gold-silica janus nanoparticles to enable contrast-enhanced multiwavelength photoacoustic imaging in vivo
Photoacoustic imaging using exogenous contrast agents has emerged as a hybrid technique that enables the deep imaging of optical properties of tissues with high spatial resolution. The power of this imaging technique can be greatly enhanced by the use of contrast agents that absorb at near-infrared...
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| Veröffentlicht in: | Nanoscale 2018-01, Vol.10 (32), p.15365-15370 |
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| creator | Park, Ji Hun Dumani, Diego S Arsiwala, Ammar Emelianov, Stanislav Kane, Ravi S |
| description | Photoacoustic imaging using exogenous contrast agents has emerged as a hybrid technique that enables the deep imaging of optical properties of tissues with high spatial resolution. The power of this imaging technique can be greatly enhanced by the use of contrast agents that absorb at near-infrared wavelengths and whose optical properties can be modulated in response to the local environment. We have designed contrast agents consisting of gold nanoparticles coated with anisotropic silica nanoshells. The tunable aggregation of these janus particles in cell culture media resulted in a dramatic amplification of photoacoustic signals in the near-infrared region. We also demonstrated imaging using these contrast agents in mammalian cells, including macrophages and breast cancer cells as well as in vivo. The ability to modulate janus particle aggregation in response to a range of stimuli in combination with the high resolution and deep penetration of multiwavelength photoacoustic imaging are attractive for a broad range of applications in diagnostic imaging and theranostics. |
| doi_str_mv | 10.1039/c8nr03973a |
| format | Article |
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Dumani, Diego S ; Arsiwala, Ammar ; Emelianov, Stanislav ; Kane, Ravi S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-e72176477e49929e5a9e8cd2cd4feef0ecad71d91db96a75e661f721f940ee9b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Acquisitions & mergers</topic><topic>Agglomeration</topic><topic>Animals</topic><topic>Cell Line, Tumor</topic><topic>Contrast agents</topic><topic>Contrast Media</topic><topic>Diagnostic software</topic><topic>Diagnostic systems</topic><topic>Gold</topic><topic>Humans</topic><topic>Lymph Nodes - diagnostic imaging</topic><topic>Macrophages</topic><topic>Medical imaging</topic><topic>Metal Nanoparticles</topic><topic>Mice</topic><topic>Nanoparticles</topic><topic>Near infrared radiation</topic><topic>Optical properties</topic><topic>Photoacoustic Techniques</topic><topic>Silicon Dioxide</topic><topic>Spatial resolution</topic><topic>Spectrum Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, Ji Hun</creatorcontrib><creatorcontrib>Dumani, Diego S</creatorcontrib><creatorcontrib>Arsiwala, Ammar</creatorcontrib><creatorcontrib>Emelianov, Stanislav</creatorcontrib><creatorcontrib>Kane, Ravi S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Nanoscale</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Ji Hun</au><au>Dumani, Diego S</au><au>Arsiwala, Ammar</au><au>Emelianov, Stanislav</au><au>Kane, Ravi S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tunable aggregation of gold-silica janus nanoparticles to enable contrast-enhanced multiwavelength photoacoustic imaging in vivo</atitle><jtitle>Nanoscale</jtitle><addtitle>Nanoscale</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>10</volume><issue>32</issue><spage>15365</spage><epage>15370</epage><pages>15365-15370</pages><issn>2040-3364</issn><eissn>2040-3372</eissn><abstract>Photoacoustic imaging using exogenous contrast agents has emerged as a hybrid technique that enables the deep imaging of optical properties of tissues with high spatial resolution. 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| source | MEDLINE; Royal Society Of Chemistry Journals 2008- |
| subjects | Acquisitions & mergers Agglomeration Animals Cell Line, Tumor Contrast agents Contrast Media Diagnostic software Diagnostic systems Gold Humans Lymph Nodes - diagnostic imaging Macrophages Medical imaging Metal Nanoparticles Mice Nanoparticles Near infrared radiation Optical properties Photoacoustic Techniques Silicon Dioxide Spatial resolution Spectrum Analysis |
| title | Tunable aggregation of gold-silica janus nanoparticles to enable contrast-enhanced multiwavelength photoacoustic imaging in vivo |
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