Regulation of Phosphorylation of Thr-308 of Akt, Cell Proliferation, and Survival by the B55α Regulatory Subunit Targeting of the Protein Phosphatase 2A Holoenzyme to Akt

Akt is a protein serine/threonine kinase that is involved in the regulation of diverse cellular processes. Phosphorylation of Akt at regulatory residues Thr-308 and Ser-473 leads to its full activation. The protein phosphatase 2A (PP2A) has long been known to negatively regulate Akt activity. The PP...

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Veröffentlicht in:	The Journal of biological chemistry 2008-01, Vol.283 (4), p.1882-1892
Hauptverfasser:	Kuo, Yi-Chun, Huang, Kai-Yun, Yang, Chung-Hsiang, Yang, Yu-San, Lee, Wen-Yu, Chiang, Chi-Wu
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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