Reversible nitrous oxide myelopathy and a polymorphism in the gene encoding 5,10-methylenetetrahydrofolate reductase

We present a case of a patient who received nitrous oxide on two occasions within a period of 8 weeks and who subsequently developed a diffuse myelopathy, characterized by upper extremity paresis, lower extremity paraplegia and neurogenic bladder. Laboratory testing revealed hyperhomocysteinaemia an...

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Veröffentlicht in:	British journal of anaesthesia : BJA 2006-02, Vol.96 (2), p.222-225
Hauptverfasser:	Lacassie, H.J., Nazar, C, Yonish, B, Sandoval, P, Muir, H.A., Mellado, P
Format:	Artikel
Sprache:	eng
Schlagworte:	10-methylenetetrahydrofolate reductase anaesthesia anaesthesia, inhalation anaesthetics gases anaesthetics gases, nitrous oxide Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anesthetics, Inhalation - adverse effects Biological and medical sciences complications complications, myelopathy enzymes enzymes, 5,10-methylenetetrahydrofolate reductase folic acid Folic Acid - therapeutic use gene gene, MTHFR Genetic Predisposition to Disease Humans Hyperhomocysteinemia - complications inhalation Male Medical sciences Methylenetetrahydrofolate Reductase (NADPH2) - genetics Middle Aged MTHFR myelopathy nitrous oxide Nitrous Oxide - adverse effects Paralysis - chemically induced Polymorphism, Genetic Postoperative Complications Spinal Cord Diseases - chemically induced Spinal Cord Diseases - drug therapy Spinal Cord Diseases - genetics Vitamin B 12 - therapeutic use vitamins vitamins, folic acid
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