Laminar Shear Stress Up-regulates Peroxiredoxins (PRX) in Endothelial Cells: PRX 1 AS A MECHANOSENSITIVE ANTIOXIDANT

Shear stress plays a significant role in endothelial cell biology and atherosclerosis development. Previous work by our group has shown that fluid flow stimulates important functional changes in cells through protein expression regulation. Peroxiredoxins (PRX) are a family of antioxidant enzymes but...

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Veröffentlicht in:	The Journal of biological chemistry 2008-01, Vol.283 (3), p.1622-1627
Hauptverfasser:	Mowbray, Amy L, Kang, Dong-Hoon, Rhee, Sue Goo, Kang, Sang Won, Jo, Hanjoong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - metabolism Cattle Cell Extracts Cells, Cultured Endothelial Cells - metabolism Hydrogen Peroxide - metabolism Mechanotransduction, Cellular Oxidative Stress Peroxiredoxins - metabolism RNA, Small Interfering - metabolism Stress, Mechanical Subcellular Fractions Up-Regulation
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