Evolutionarily Distinct Residues in the Uncoupling Protein UCP1 Are Essential for Its Characteristic Basal Proton Conductance

The uncoupling proteins (UCPs) are mitochondrial transporters that modulate the efficiency of oxidative phosphorylation. Members of this family have been described in many phyla within the animal and plant kingdoms, as well as in fungi. The mammalian uncoupling protein UCP1 is activated by fatty aci...

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Veröffentlicht in:	Journal of molecular biology 2006-06, Vol.359 (4), p.1010-1022
Hauptverfasser:	Jiménez-Jiménez, Jesús, Zardoya, Rafael, Ledesma, Amalia, García de Lacoba, Mario, Zaragoza, Pilar, Mar González-Barroso, M., Rial, Eduardo
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino Acid Substitution Base Sequence Carrier Proteins - chemistry Carrier Proteins - genetics Carrier Proteins - metabolism Conserved Sequence Evolution, Molecular Histidine - genetics Ion Channels Membrane Proteins - chemistry Membrane Proteins - genetics Membrane Proteins - metabolism Membrane Transport Proteins - genetics Membrane Transport Proteins - metabolism mitochondria Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism molecular evolution Molecular Sequence Data mutagenesis Mutagenesis, Site-Directed Phylogeny Protons Recombinant Proteins - genetics Recombinant Proteins - metabolism Sequence Homology, Amino Acid transporter uncoupling protein Uncoupling Protein 1 Uncoupling Protein 2 Yeasts - genetics
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