Urinary angiotensinogen level is increased in renal transplant recipients with masked hypertension and is correlated with left ventricular mass index and albuminuria in these patients
Activation of the local renin‐angiotensin system (RAS) is an independent risk factor for the development of proteinuria and left ventricular hypertrophy (LVH) more commonly seen in masked hypertensives. It has been reported that urinary angiotensinogen (UAGT) level provides a specific index of the i...
Gespeichert in:
| Veröffentlicht in: | Clinical transplantation 2018-09, Vol.32 (9), p.e13375-n/a |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | n/a |
|---|---|
| container_issue | 9 |
| container_start_page | e13375 |
| container_title | Clinical transplantation |
| container_volume | 32 |
| creator | Tiryaki, Ozlem Usalan, Celalettin Kul, Seval Tarakcioglu, Mehmet Sucu, Murat Yildiz, Fahrettin Coban, Sacit |
| description | Activation of the local renin‐angiotensin system (RAS) is an independent risk factor for the development of proteinuria and left ventricular hypertrophy (LVH) more commonly seen in masked hypertensives. It has been reported that urinary angiotensinogen (UAGT) level provides a specific index of the intrarenal RAS status. The aim of this study was to evaluate the association between UAGT and left ventricular mass index (LVMI) and urinary albumin‐creatinine ratio (UACR) in renal transplant recipients (RTRs) with masked hypertension (HT). A total of 116 non‐diabetic‐treated hypertensive RTRs were included in this study. The patients were divided into two groups: masked hypertensives and controlled hypertensives. Forty‐two (36.2%) of RTRs had masked HT. Mean UACR and LVMI levels were higher in RTRs with masked HT than in RTRs with controlled HT (P |
| doi_str_mv | 10.1111/ctr.13375 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2084345172</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2084345172</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3255-3350cff5378915c66a45a91e16147d68b5611b601818cbeb6a1346f23625c7ed3</originalsourceid><addsrcrecordid>eNp1kc1O3DAUha2qCKYDi74A8rIsZvBP7CRLNCoUCalSBevIcW4Yt44TbIfpPBmvVyczsKs3vrr-7jnyPQh9pWRN07nW0a8p57n4hBaUl-WKEMo-owUpCUu15GfoSwi_U1dSKU7RGSekIKxgC_T25I1Tfo-VezZ9BBeM65_BYQuvYLEJ2DjtQQVoUoU9OGVx9MqFwSoXU0ObwYCLAe9M3OJOhT8J3e4H8LNa75J0Mwnp3nuwKqbnGbXQRvyaRr3Ro1V-mp3sGvg7jyhbj51xozdqso5bCIAHFWe3c3TSKhvg4ngv0dPt98fNj9XDz7v7zc3DSnMmxIpzQXTbCp4XJRVaSpUJVVJIi8jyRha1kJTWktCCFrqGWirKM9kyLpnQOTR8ib4ddAffv4wQYtWZoMGmz0M_hoqRIuOZoDlL6NUB1b4PwUNbDd50abcVJdWUU5VyquacEnt5lB3rDpoP8j2YBFwfgJ2xsP-_UrV5_HWQ_AdA66Ef</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2084345172</pqid></control><display><type>article</type><title>Urinary angiotensinogen level is increased in renal transplant recipients with masked hypertension and is correlated with left ventricular mass index and albuminuria in these patients</title><source>Access via Wiley Online Library</source><creator>Tiryaki, Ozlem ; Usalan, Celalettin ; Kul, Seval ; Tarakcioglu, Mehmet ; Sucu, Murat ; Yildiz, Fahrettin ; Coban, Sacit</creator><creatorcontrib>Tiryaki, Ozlem ; Usalan, Celalettin ; Kul, Seval ; Tarakcioglu, Mehmet ; Sucu, Murat ; Yildiz, Fahrettin ; Coban, Sacit</creatorcontrib><description>Activation of the local renin‐angiotensin system (RAS) is an independent risk factor for the development of proteinuria and left ventricular hypertrophy (LVH) more commonly seen in masked hypertensives. It has been reported that urinary angiotensinogen (UAGT) level provides a specific index of the intrarenal RAS status. The aim of this study was to evaluate the association between UAGT and left ventricular mass index (LVMI) and urinary albumin‐creatinine ratio (UACR) in renal transplant recipients (RTRs) with masked hypertension (HT). A total of 116 non‐diabetic‐treated hypertensive RTRs were included in this study. The patients were divided into two groups: masked hypertensives and controlled hypertensives. Forty‐two (36.2%) of RTRs had masked HT. Mean UACR and LVMI levels were higher in RTRs with masked HT than in RTRs with controlled HT (P < 0.001). UAGT level was also higher in masked hypertensives compared to controlled hypertensives (P < 0.001). Multivariable regression analysis showed that UAGT was positively correlated with UACR (β = 0.024, P = 0.001) and LVMI (β = 0.082, P = 0.001) in masked hypertensives. Consequently, masked HT was considerably frequent (36.2%) in treated hypertensive RTRs and high UAGT levels accompanied by high albuminuria and LVMI levels were seen in these patients. Overproduction of the UAGT may play a pivotal role in the development of LVH and proteinuria in masked hypertensives.</description><identifier>ISSN: 0902-0063</identifier><identifier>EISSN: 1399-0012</identifier><identifier>DOI: 10.1111/ctr.13375</identifier><identifier>PMID: 30080282</identifier><language>eng</language><publisher>Denmark</publisher><subject>albuminuria ; ambulatory blood pressure ; left ventricular mass index ; masked hypertension ; renal transplant recipients ; urinary angiotensinogen</subject><ispartof>Clinical transplantation, 2018-09, Vol.32 (9), p.e13375-n/a</ispartof><rights>2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3255-3350cff5378915c66a45a91e16147d68b5611b601818cbeb6a1346f23625c7ed3</citedby><cites>FETCH-LOGICAL-c3255-3350cff5378915c66a45a91e16147d68b5611b601818cbeb6a1346f23625c7ed3</cites><orcidid>0000-0002-9967-1925</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fctr.13375$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fctr.13375$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,27933,27934,45583,45584</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30080282$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tiryaki, Ozlem</creatorcontrib><creatorcontrib>Usalan, Celalettin</creatorcontrib><creatorcontrib>Kul, Seval</creatorcontrib><creatorcontrib>Tarakcioglu, Mehmet</creatorcontrib><creatorcontrib>Sucu, Murat</creatorcontrib><creatorcontrib>Yildiz, Fahrettin</creatorcontrib><creatorcontrib>Coban, Sacit</creatorcontrib><title>Urinary angiotensinogen level is increased in renal transplant recipients with masked hypertension and is correlated with left ventricular mass index and albuminuria in these patients</title><title>Clinical transplantation</title><addtitle>Clin Transplant</addtitle><description>Activation of the local renin‐angiotensin system (RAS) is an independent risk factor for the development of proteinuria and left ventricular hypertrophy (LVH) more commonly seen in masked hypertensives. It has been reported that urinary angiotensinogen (UAGT) level provides a specific index of the intrarenal RAS status. The aim of this study was to evaluate the association between UAGT and left ventricular mass index (LVMI) and urinary albumin‐creatinine ratio (UACR) in renal transplant recipients (RTRs) with masked hypertension (HT). A total of 116 non‐diabetic‐treated hypertensive RTRs were included in this study. The patients were divided into two groups: masked hypertensives and controlled hypertensives. Forty‐two (36.2%) of RTRs had masked HT. Mean UACR and LVMI levels were higher in RTRs with masked HT than in RTRs with controlled HT (P < 0.001). UAGT level was also higher in masked hypertensives compared to controlled hypertensives (P < 0.001). Multivariable regression analysis showed that UAGT was positively correlated with UACR (β = 0.024, P = 0.001) and LVMI (β = 0.082, P = 0.001) in masked hypertensives. Consequently, masked HT was considerably frequent (36.2%) in treated hypertensive RTRs and high UAGT levels accompanied by high albuminuria and LVMI levels were seen in these patients. Overproduction of the UAGT may play a pivotal role in the development of LVH and proteinuria in masked hypertensives.</description><subject>albuminuria</subject><subject>ambulatory blood pressure</subject><subject>left ventricular mass index</subject><subject>masked hypertension</subject><subject>renal transplant recipients</subject><subject>urinary angiotensinogen</subject><issn>0902-0063</issn><issn>1399-0012</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kc1O3DAUha2qCKYDi74A8rIsZvBP7CRLNCoUCalSBevIcW4Yt44TbIfpPBmvVyczsKs3vrr-7jnyPQh9pWRN07nW0a8p57n4hBaUl-WKEMo-owUpCUu15GfoSwi_U1dSKU7RGSekIKxgC_T25I1Tfo-VezZ9BBeM65_BYQuvYLEJ2DjtQQVoUoU9OGVx9MqFwSoXU0ObwYCLAe9M3OJOhT8J3e4H8LNa75J0Mwnp3nuwKqbnGbXQRvyaRr3Ro1V-mp3sGvg7jyhbj51xozdqso5bCIAHFWe3c3TSKhvg4ngv0dPt98fNj9XDz7v7zc3DSnMmxIpzQXTbCp4XJRVaSpUJVVJIi8jyRha1kJTWktCCFrqGWirKM9kyLpnQOTR8ib4ddAffv4wQYtWZoMGmz0M_hoqRIuOZoDlL6NUB1b4PwUNbDd50abcVJdWUU5VyquacEnt5lB3rDpoP8j2YBFwfgJ2xsP-_UrV5_HWQ_AdA66Ef</recordid><startdate>201809</startdate><enddate>201809</enddate><creator>Tiryaki, Ozlem</creator><creator>Usalan, Celalettin</creator><creator>Kul, Seval</creator><creator>Tarakcioglu, Mehmet</creator><creator>Sucu, Murat</creator><creator>Yildiz, Fahrettin</creator><creator>Coban, Sacit</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9967-1925</orcidid></search><sort><creationdate>201809</creationdate><title>Urinary angiotensinogen level is increased in renal transplant recipients with masked hypertension and is correlated with left ventricular mass index and albuminuria in these patients</title><author>Tiryaki, Ozlem ; Usalan, Celalettin ; Kul, Seval ; Tarakcioglu, Mehmet ; Sucu, Murat ; Yildiz, Fahrettin ; Coban, Sacit</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3255-3350cff5378915c66a45a91e16147d68b5611b601818cbeb6a1346f23625c7ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>albuminuria</topic><topic>ambulatory blood pressure</topic><topic>left ventricular mass index</topic><topic>masked hypertension</topic><topic>renal transplant recipients</topic><topic>urinary angiotensinogen</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tiryaki, Ozlem</creatorcontrib><creatorcontrib>Usalan, Celalettin</creatorcontrib><creatorcontrib>Kul, Seval</creatorcontrib><creatorcontrib>Tarakcioglu, Mehmet</creatorcontrib><creatorcontrib>Sucu, Murat</creatorcontrib><creatorcontrib>Yildiz, Fahrettin</creatorcontrib><creatorcontrib>Coban, Sacit</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tiryaki, Ozlem</au><au>Usalan, Celalettin</au><au>Kul, Seval</au><au>Tarakcioglu, Mehmet</au><au>Sucu, Murat</au><au>Yildiz, Fahrettin</au><au>Coban, Sacit</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Urinary angiotensinogen level is increased in renal transplant recipients with masked hypertension and is correlated with left ventricular mass index and albuminuria in these patients</atitle><jtitle>Clinical transplantation</jtitle><addtitle>Clin Transplant</addtitle><date>2018-09</date><risdate>2018</risdate><volume>32</volume><issue>9</issue><spage>e13375</spage><epage>n/a</epage><pages>e13375-n/a</pages><issn>0902-0063</issn><eissn>1399-0012</eissn><abstract>Activation of the local renin‐angiotensin system (RAS) is an independent risk factor for the development of proteinuria and left ventricular hypertrophy (LVH) more commonly seen in masked hypertensives. It has been reported that urinary angiotensinogen (UAGT) level provides a specific index of the intrarenal RAS status. The aim of this study was to evaluate the association between UAGT and left ventricular mass index (LVMI) and urinary albumin‐creatinine ratio (UACR) in renal transplant recipients (RTRs) with masked hypertension (HT). A total of 116 non‐diabetic‐treated hypertensive RTRs were included in this study. The patients were divided into two groups: masked hypertensives and controlled hypertensives. Forty‐two (36.2%) of RTRs had masked HT. Mean UACR and LVMI levels were higher in RTRs with masked HT than in RTRs with controlled HT (P < 0.001). UAGT level was also higher in masked hypertensives compared to controlled hypertensives (P < 0.001). Multivariable regression analysis showed that UAGT was positively correlated with UACR (β = 0.024, P = 0.001) and LVMI (β = 0.082, P = 0.001) in masked hypertensives. Consequently, masked HT was considerably frequent (36.2%) in treated hypertensive RTRs and high UAGT levels accompanied by high albuminuria and LVMI levels were seen in these patients. Overproduction of the UAGT may play a pivotal role in the development of LVH and proteinuria in masked hypertensives.</abstract><cop>Denmark</cop><pmid>30080282</pmid><doi>10.1111/ctr.13375</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-9967-1925</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0902-0063 |
| ispartof | Clinical transplantation, 2018-09, Vol.32 (9), p.e13375-n/a |
| issn | 0902-0063 1399-0012 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2084345172 |
| source | Access via Wiley Online Library |
| subjects | albuminuria ambulatory blood pressure left ventricular mass index masked hypertension renal transplant recipients urinary angiotensinogen |
| title | Urinary angiotensinogen level is increased in renal transplant recipients with masked hypertension and is correlated with left ventricular mass index and albuminuria in these patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-01T05%3A46%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Urinary%20angiotensinogen%20level%20is%20increased%20in%20renal%20transplant%20recipients%20with%20masked%20hypertension%20and%20is%20correlated%20with%20left%20ventricular%20mass%20index%20and%20albuminuria%20in%20these%20patients&rft.jtitle=Clinical%20transplantation&rft.au=Tiryaki,%20Ozlem&rft.date=2018-09&rft.volume=32&rft.issue=9&rft.spage=e13375&rft.epage=n/a&rft.pages=e13375-n/a&rft.issn=0902-0063&rft.eissn=1399-0012&rft_id=info:doi/10.1111/ctr.13375&rft_dat=%3Cproquest_cross%3E2084345172%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2084345172&rft_id=info:pmid/30080282&rfr_iscdi=true |