Azulene-based compounds for targeting orexin receptors

A library of 70 000 synthetically accessible azulene-based compounds was virtually screened at the OX2 receptor. Based on the results, a series of azulene derivatives was synthesized and the binding to and activation of both orexin receptor subtypes were assessed. Two most promising binders were det...

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Veröffentlicht in:	European journal of medicinal chemistry 2018-09, Vol.157, p.88-100
Hauptverfasser:	Leino, Teppo O., Turku, Ainoleena, Yli-Kauhaluoma, Jari, Kukkonen, Jyrki P., Xhaard, Henri, Wallén, Erik A.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonist Antagonist Azulene Orexin receptor Potentiator Sleep-wake regulation
Online-Zugang:	Volltext
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