Optimization of β-cyclodextrin consolidated micellar dispersion for promoting the transcorneal permeation of a practically insoluble drug

[Display omitted] Development of efficient ocular drug delivery system for antifungal drugs becomes a must nowadays to face and eradicate the widely spread ophthalmic fungal infections. Itraconazole, a triazole antifungal, is struggling to penetrate the cornea and subsequently, its efficacy is limit...

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Veröffentlicht in:	International journal of pharmaceutics 2018-10, Vol.549 (1-2), p.249-260
Hauptverfasser:	Sayed, Sinar, Elsayed, Ibrahim, Ismail, Maha M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesiveness Administration, Ophthalmic Animals Antifungal Agents - administration & dosage Antifungal Agents - chemistry Antifungal Agents - metabolism Aspergillosis - drug therapy Aspergillosis - metabolism Aspergillosis - microbiology Aspergillus niger - drug effects Aspergillus niger - growth & development beta-Cyclodextrins - chemistry Cornea - drug effects Cornea - metabolism Cornea - microbiology Cyclodextrin Disease Models, Animal Drug Compounding Drug Liberation Excipients - chemistry Eye Infections, Fungal - drug therapy Eye Infections, Fungal - metabolism Eye Infections, Fungal - microbiology Itraconazole Itraconazole - administration & dosage Itraconazole - chemistry Itraconazole - metabolism Keratitis Keratitis - drug therapy Keratitis - metabolism Keratitis - microbiology Male Micelles Ocular Absorption Particle Size Permeability Rabbits Solubility Technology, Pharmaceutical - methods Transcorneal
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