Inflammation and cancer: An ancient link with novel potentials

Infection and chronic inflammation contribute to about 1 in 4 of all cancer cases. Mediators of the inflammatory response, e.g., cytokines, free radicals, prostaglandins and growth factors, can induce genetic and epigenetic changes including point mutations in tumor suppressor genes, DNA methylation...

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Veröffentlicht in:	International journal of cancer 2007-12, Vol.121 (11), p.2373-2380
Hauptverfasser:	Perwez Hussain, S., Harris, Curtis C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals cancer Chronic Disease Cyclooxygenase 2 - metabolism Cytokines - metabolism Disease Progression DNA Methylation Epigenesis, Genetic Free Radicals - adverse effects Genes, p53 - genetics Humans Immunity, Innate inflammation Inflammation - complications Inflammation - microbiology Inflammation - parasitology Inflammation - virology Inflammation Mediators - adverse effects Inflammation Mediators - metabolism Intercellular Signaling Peptides and Proteins - metabolism microRNA MicroRNAs Neoplasms - etiology Neoplasms - genetics Neoplasms - immunology Neoplasms - metabolism Neoplasms - microbiology Neoplasms - virology NF-kappa B - metabolism nitric oxide Nitric Oxide Synthase - metabolism Point Mutation Prostaglandins - metabolism Risk Assessment Risk Factors Signal Transduction
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