Attenuation of nociception in a model of acute pancreatitis by an NK-1 antagonist

Substance P (SP) acting at the NK-1 neurokinin receptor has a well-documented role in the transmission and maintenance of nociceptive information. SP is found in the majority of fibers innervating the pancreas, and it is up-regulated after pancreatic inflammation. The aim of this study was to invest...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 2004-03, Vol.77 (3), p.631-640
Hauptverfasser:	Vera-Portocarrero, Louis P., Westlund, Karin N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Animals Biological and medical sciences Disease Models, Animal Fundamental and applied biological sciences. Psychology Hyperalgesia Inflammation Male Medical sciences Neurokinin-1 Receptor Antagonists Neuropharmacology Organotin Compounds - toxicity Pain Pain Measurement - drug effects Pain Measurement - methods Pancreatitis Pancreatitis - chemically induced Pancreatitis - metabolism Pancreatitis - physiopathology Pharmacology. Drug treatments Piperidines - pharmacology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Inbred Lew Receptors, Neurokinin-1 - metabolism Substance P
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