Group S8A serine proteases, including a novel enzyme cadeprin, induce long-lasting, metabotropic glutamate receptor-dependent synaptic depression in rat hippocampal slices

Long‐term potentiation and long‐term depression (LTD) are forms of synaptic plasticity in the central nervous system. We now report that a group of chymotrypsin‐like serine proteases, especially members of the S8A subfamily, induce LTD of evoked potentials in rat hippocampal slices. The proteolytic...

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Veröffentlicht in:	The European journal of neuroscience 2007-10, Vol.26 (7), p.1870-1880
Hauptverfasser:	MacGregor, Duncan G., Mallon, Andrew P., Harvey, Alan. L., Young, Louise, Nimmo, Hugh G., Stone, Trevor W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aspergillus Benzopyrans - pharmacology chymotrypsin Dose-Response Relationship, Drug Dose-Response Relationship, Radiation Drug Interactions Electric Stimulation - methods Enzyme Inhibitors - pharmacology Hippocampus - cytology Hippocampus - drug effects In Vitro Techniques long-term depression long-term potentiation Long-Term Synaptic Depression - drug effects Male Patch-Clamp Techniques - methods proteinase K Rats Rats, Wistar Receptors, Metabotropic Glutamate - antagonists & inhibitors Receptors, Metabotropic Glutamate - physiology Serine Endopeptidases - chemistry Serine Endopeptidases - pharmacology serine proteases subtilisin
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