Renal clearance of quantum dots
The field of nanotechnology holds great promise for the diagnosis and treatment of human disease. However, the size and charge of most nanoparticles preclude their efficient clearance from the body as intact nanoparticles. Without such clearance or their biodegradation into biologically benign compo...
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| Veröffentlicht in: | Nature biotechnology 2007-10, Vol.25 (10), p.1165-1170 |
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| container_title | Nature biotechnology |
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| creator | Soo Choi, Hak Liu, Wenhao Misra, Preeti Tanaka, Eiichi Zimmer, John P Itty Ipe, Binil Bawendi, Moungi G Frangioni, John V |
| description | The field of nanotechnology holds great promise for the diagnosis and treatment of human disease. However, the size and charge of most nanoparticles preclude their efficient clearance from the body as intact nanoparticles. Without such clearance or their biodegradation into biologically benign components, toxicity is potentially amplified and radiological imaging is hindered. Using intravenously administered quantum dots in rodents as a model system, we have precisely defined the requirements for renal filtration and urinary excretion of inorganic, metal-containing nanoparticles. Zwitterionic or neutral organic coatings prevented adsorption of serum proteins, which otherwise increased hydrodynamic diameter by >15 nm and prevented renal excretion. A final hydrodynamic diameter |
| doi_str_mv | 10.1038/nbt1340 |
| format | Article |
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However, the size and charge of most nanoparticles preclude their efficient clearance from the body as intact nanoparticles. Without such clearance or their biodegradation into biologically benign components, toxicity is potentially amplified and radiological imaging is hindered. Using intravenously administered quantum dots in rodents as a model system, we have precisely defined the requirements for renal filtration and urinary excretion of inorganic, metal-containing nanoparticles. Zwitterionic or neutral organic coatings prevented adsorption of serum proteins, which otherwise increased hydrodynamic diameter by >15 nm and prevented renal excretion. A final hydrodynamic diameter <5.5 nm resulted in rapid and efficient urinary excretion and elimination of quantum dots from the body. This study provides a foundation for the design and development of biologically targeted nanoparticles for biomedical applications.</description><identifier>ISSN: 1087-0156</identifier><identifier>EISSN: 1546-1696</identifier><identifier>DOI: 10.1038/nbt1340</identifier><identifier>PMID: 17891134</identifier><identifier>CODEN: NABIF9</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Adsorption ; Agriculture ; Animals ; Biodegradation ; Bioinformatics ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedical Engineering/Biotechnology ; Biomedical materials ; Biomedical research ; Biomedicine ; Biotechnology ; Contrast Media ; Diagnostic Imaging ; Drug Stability ; Excretion ; Filtration ; Fundamental and applied biological sciences. Psychology ; Health. Pharmaceutical industry ; Industrial applications and implications. Economical aspects ; Kidney - metabolism ; letter ; Life Sciences ; Male ; Miscellaneous ; Nanoparticles ; Nanotechnology ; Particle Size ; Quantum Dots ; Rats ; Rats, Sprague-Dawley ; Rodents</subject><ispartof>Nature biotechnology, 2007-10, Vol.25 (10), p.1165-1170</ispartof><rights>Springer Nature America, Inc. 2007</rights><rights>2009 INIST-CNRS</rights><rights>COPYRIGHT 2007 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Oct 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-455a65bd7bd96581a56eb1934094b5edd351e2c6d945e31fa4d371199f61e8e63</citedby><cites>FETCH-LOGICAL-c540t-455a65bd7bd96581a56eb1934094b5edd351e2c6d945e31fa4d371199f61e8e63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/nbt1340$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/nbt1340$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20635405$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17891134$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Soo Choi, Hak</creatorcontrib><creatorcontrib>Liu, Wenhao</creatorcontrib><creatorcontrib>Misra, Preeti</creatorcontrib><creatorcontrib>Tanaka, Eiichi</creatorcontrib><creatorcontrib>Zimmer, John P</creatorcontrib><creatorcontrib>Itty Ipe, Binil</creatorcontrib><creatorcontrib>Bawendi, Moungi G</creatorcontrib><creatorcontrib>Frangioni, John V</creatorcontrib><title>Renal clearance of quantum dots</title><title>Nature biotechnology</title><addtitle>Nat Biotechnol</addtitle><addtitle>Nat Biotechnol</addtitle><description>The field of nanotechnology holds great promise for the diagnosis and treatment of human disease. However, the size and charge of most nanoparticles preclude their efficient clearance from the body as intact nanoparticles. Without such clearance or their biodegradation into biologically benign components, toxicity is potentially amplified and radiological imaging is hindered. Using intravenously administered quantum dots in rodents as a model system, we have precisely defined the requirements for renal filtration and urinary excretion of inorganic, metal-containing nanoparticles. Zwitterionic or neutral organic coatings prevented adsorption of serum proteins, which otherwise increased hydrodynamic diameter by >15 nm and prevented renal excretion. A final hydrodynamic diameter <5.5 nm resulted in rapid and efficient urinary excretion and elimination of quantum dots from the body. 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| subjects | Adsorption Agriculture Animals Biodegradation Bioinformatics Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedical materials Biomedical research Biomedicine Biotechnology Contrast Media Diagnostic Imaging Drug Stability Excretion Filtration Fundamental and applied biological sciences. Psychology Health. Pharmaceutical industry Industrial applications and implications. Economical aspects Kidney - metabolism letter Life Sciences Male Miscellaneous Nanoparticles Nanotechnology Particle Size Quantum Dots Rats Rats, Sprague-Dawley Rodents |
| title | Renal clearance of quantum dots |
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