The HIV1 Protein Vpr Acts to Promote G sub(2) Cell Cycle Arrest by Engaging a DDB1 and Cullin4A-containing Ubiquitin Ligase Complex Using VprBP/DCAF1 as an Adaptor

The roles of the HIV1 protein Vpr in virus replication and pathogenesis remain unclear. Expression of Vpr in dividing cells causes cell cycle arrest in G sub(2). Vpr also facilitates low titer infection of terminally differentiated macrophages, enhances transcription, promotes apoptosis, and targets...

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Veröffentlicht in:	The Journal of biological chemistry 2007-09, Vol.282 (37), p.27046-27057
Hauptverfasser:	Wen, Xiaoyun, Duus, Karen M, Friedrich, Thomas D, de Noronha, Carlos MC
Format:	Artikel
Sprache:	eng
Schlagworte:	Human immunodeficiency virus 1 Human immunodeficiency virus 2
Online-Zugang:	Volltext
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