Mancozeb exposure results in manganese accumulation and Nrf2-related antioxidant responses in the brain of common carp Cyprinus carpio
Manganese (Mn)-containing dithiocarbamates such as Mancozeb (MZ) have been shown to induce oxidative stress-related toxicity in rodents and humans. However, little is known about the neurotoxic effects induced by MZ in fish. In this study, carp ( Cyprinus carpio ) were exposed to non-lethal waterbor...
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| Veröffentlicht in: | Environmental science and pollution research international 2018-06, Vol.25 (16), p.15529-15540 |
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| creator | Costa-Silva, Dennis Guilherme Lopes, Andressa Rubim Martins, Illana Kemmerich Leandro, Luana Paganotto Nunes, Mauro Eugênio Medina de Carvalho, Nelson Rodrigues Rodrigues, Nathane Rosa Macedo, Giulianna Echeveria Saidelles, Ana Paula Aguiar, Cassiana Doneda, Morgana Flores, Erico Marlon Moraes Posser, Thais Franco, Jeferson Luis |
| description | Manganese (Mn)-containing dithiocarbamates such as Mancozeb (MZ) have been shown to induce oxidative stress-related toxicity in rodents and humans. However, little is known about the neurotoxic effects induced by MZ in fish. In this study, carp (
Cyprinus carpio
) were exposed to non-lethal waterborne concentrations of MZ, and oxidative stress parameters as well as metal accumulation in fish brains were evaluated. The experimental groups were as follows: control, MZ 5 mg/L, and MZ 10 mg/L. Fish were exposed for 7 days, and then brain was removed and prepared for subsequent analysis of antioxidant enzymes, reactive oxygen species (ROS), and expression of Nrf2 and phosphoNrf2. In parallel, manganese (Mn) levels were evaluated in blood and brain tissues. Mn levels were significantly increased in blood and brain of MZ-exposed carps. In addition, a concentration-dependent increase (
p
|
| doi_str_mv | 10.1007/s11356-018-1724-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2084037047</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2084037047</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-a9e7187ac04aa4d272dad1f851adb0bb2cb5b6acb79e746d90a38f82be9ab5323</originalsourceid><addsrcrecordid>eNp1kctu1TAQhi0EoofCA7BBltiwMfUtcbxER9ykUjawtsaXlFSJHexYankAnrs-PQUkpK7GHn3_Px7_CL1k9C2jVJ0VxkTXE8oGwhSXRD9CO9YzSZTU-jHaUS0lYULKE_SslCtKOdVcPUUnXHe95lTs0O8vEF36FSwO12sqNQecQ6nzVvAU8QLxEmIoAYNzdakzbFOKGKLHF3nkJIfWCb41Wv968q0e5GuKJdwZbD8CthnaKY3YpWVpagd5xfubNU-xlrvblJ6jJyPMJby4r6fo-4f33_afyPnXj5_3786Jk5JvBHRQbFDgqASQnivuwbNx6Bh4S63lzna2B2dVA2XvNQUxjAO3QYPtBBen6M3Rd83pZw1lM8tUXJjntmWqxXA6SCoUlaqhr_9Dr1LNsb2uUawflJCiaxQ7Ui6nUnIYTdtrgXxjGDWHkMwxJNNCMoeQjG6aV_fO1S7B_1X8SaUB_AiUwyddhvxv9MOut5Z6n3A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2016873435</pqid></control><display><type>article</type><title>Mancozeb exposure results in manganese accumulation and Nrf2-related antioxidant responses in the brain of common carp Cyprinus carpio</title><source>MEDLINE</source><source>Springer Journals</source><creator>Costa-Silva, Dennis Guilherme ; Lopes, Andressa Rubim ; Martins, Illana Kemmerich ; Leandro, Luana Paganotto ; Nunes, Mauro Eugênio Medina ; de Carvalho, Nelson Rodrigues ; Rodrigues, Nathane Rosa ; Macedo, Giulianna Echeveria ; Saidelles, Ana Paula ; Aguiar, Cassiana ; Doneda, Morgana ; Flores, Erico Marlon Moraes ; Posser, Thais ; Franco, Jeferson Luis</creator><creatorcontrib>Costa-Silva, Dennis Guilherme ; Lopes, Andressa Rubim ; Martins, Illana Kemmerich ; Leandro, Luana Paganotto ; Nunes, Mauro Eugênio Medina ; de Carvalho, Nelson Rodrigues ; Rodrigues, Nathane Rosa ; Macedo, Giulianna Echeveria ; Saidelles, Ana Paula ; Aguiar, Cassiana ; Doneda, Morgana ; Flores, Erico Marlon Moraes ; Posser, Thais ; Franco, Jeferson Luis</creatorcontrib><description>Manganese (Mn)-containing dithiocarbamates such as Mancozeb (MZ) have been shown to induce oxidative stress-related toxicity in rodents and humans. However, little is known about the neurotoxic effects induced by MZ in fish. In this study, carp (
Cyprinus carpio
) were exposed to non-lethal waterborne concentrations of MZ, and oxidative stress parameters as well as metal accumulation in fish brains were evaluated. The experimental groups were as follows: control, MZ 5 mg/L, and MZ 10 mg/L. Fish were exposed for 7 days, and then brain was removed and prepared for subsequent analysis of antioxidant enzymes, reactive oxygen species (ROS), and expression of Nrf2 and phosphoNrf2. In parallel, manganese (Mn) levels were evaluated in blood and brain tissues. Mn levels were significantly increased in blood and brain of MZ-exposed carps. In addition, a concentration-dependent increase (
p
< 0.05) in ROS levels was observed in parallel to increments (
p
< 0.05) in the activity of major antioxidant enzymes, such as GPx, GR, and GST. On the other hand, significant decreases (
p
< 0.05) in CAT and SOD activities were observed. The expression of total and phosphorylated forms of Nrf2 was significantly (
p
< 0.05) upregulated in the brain of carps exposed to Mz when compared to the control, indicating an activation of the Nrf2 antioxidant pathway. Our study showed for the first time the activation of the Nrf2/ARE pathway and bioaccumulation of Mn induced by MZ exposure in fish species, highlighting important mechanisms of action and its toxicological impacts to aquatic organisms.</description><identifier>ISSN: 0944-1344</identifier><identifier>EISSN: 1614-7499</identifier><identifier>DOI: 10.1007/s11356-018-1724-9</identifier><identifier>PMID: 29569203</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Activation ; Animals ; Antioxidants ; Antioxidants - metabolism ; Aquatic organisms ; Aquatic Pollution ; Atmospheric Protection/Air Quality Control/Air Pollution ; Bioaccumulation ; Blood ; Brain ; Brain - drug effects ; Brain - metabolism ; Carp ; Carps - metabolism ; Cyprinidae ; Cyprinus carpio ; Dose-Response Relationship, Drug ; Earth and Environmental Science ; Ecotoxicology ; Environment ; Environmental Chemistry ; Environmental Health ; Environmental science ; Enzymes ; Exposure ; Fish ; Fish Proteins - genetics ; Fish Proteins - metabolism ; Fungicides ; Fungicides, Industrial - toxicity ; Mancozeb ; Maneb - toxicity ; Manganese ; Manganese - metabolism ; Neurotoxicity ; NF-E2-Related Factor 2 - genetics ; NF-E2-Related Factor 2 - metabolism ; Oxidative stress ; Reactive oxygen species ; Research Article ; Rodents ; Superoxide dismutase ; Toxicity ; Waste Water Technology ; Water Management ; Water Pollutants, Chemical - toxicity ; Water Pollution Control ; Zineb - toxicity</subject><ispartof>Environmental science and pollution research international, 2018-06, Vol.25 (16), p.15529-15540</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2018</rights><rights>Environmental Science and Pollution Research is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-a9e7187ac04aa4d272dad1f851adb0bb2cb5b6acb79e746d90a38f82be9ab5323</citedby><cites>FETCH-LOGICAL-c442t-a9e7187ac04aa4d272dad1f851adb0bb2cb5b6acb79e746d90a38f82be9ab5323</cites><orcidid>0000-0002-3874-8618</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11356-018-1724-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11356-018-1724-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29569203$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Costa-Silva, Dennis Guilherme</creatorcontrib><creatorcontrib>Lopes, Andressa Rubim</creatorcontrib><creatorcontrib>Martins, Illana Kemmerich</creatorcontrib><creatorcontrib>Leandro, Luana Paganotto</creatorcontrib><creatorcontrib>Nunes, Mauro Eugênio Medina</creatorcontrib><creatorcontrib>de Carvalho, Nelson Rodrigues</creatorcontrib><creatorcontrib>Rodrigues, Nathane Rosa</creatorcontrib><creatorcontrib>Macedo, Giulianna Echeveria</creatorcontrib><creatorcontrib>Saidelles, Ana Paula</creatorcontrib><creatorcontrib>Aguiar, Cassiana</creatorcontrib><creatorcontrib>Doneda, Morgana</creatorcontrib><creatorcontrib>Flores, Erico Marlon Moraes</creatorcontrib><creatorcontrib>Posser, Thais</creatorcontrib><creatorcontrib>Franco, Jeferson Luis</creatorcontrib><title>Mancozeb exposure results in manganese accumulation and Nrf2-related antioxidant responses in the brain of common carp Cyprinus carpio</title><title>Environmental science and pollution research international</title><addtitle>Environ Sci Pollut Res</addtitle><addtitle>Environ Sci Pollut Res Int</addtitle><description>Manganese (Mn)-containing dithiocarbamates such as Mancozeb (MZ) have been shown to induce oxidative stress-related toxicity in rodents and humans. However, little is known about the neurotoxic effects induced by MZ in fish. In this study, carp (
Cyprinus carpio
) were exposed to non-lethal waterborne concentrations of MZ, and oxidative stress parameters as well as metal accumulation in fish brains were evaluated. The experimental groups were as follows: control, MZ 5 mg/L, and MZ 10 mg/L. Fish were exposed for 7 days, and then brain was removed and prepared for subsequent analysis of antioxidant enzymes, reactive oxygen species (ROS), and expression of Nrf2 and phosphoNrf2. In parallel, manganese (Mn) levels were evaluated in blood and brain tissues. Mn levels were significantly increased in blood and brain of MZ-exposed carps. In addition, a concentration-dependent increase (
p
< 0.05) in ROS levels was observed in parallel to increments (
p
< 0.05) in the activity of major antioxidant enzymes, such as GPx, GR, and GST. On the other hand, significant decreases (
p
< 0.05) in CAT and SOD activities were observed. The expression of total and phosphorylated forms of Nrf2 was significantly (
p
< 0.05) upregulated in the brain of carps exposed to Mz when compared to the control, indicating an activation of the Nrf2 antioxidant pathway. Our study showed for the first time the activation of the Nrf2/ARE pathway and bioaccumulation of Mn induced by MZ exposure in fish species, highlighting important mechanisms of action and its toxicological impacts to aquatic organisms.</description><subject>Activation</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Antioxidants - metabolism</subject><subject>Aquatic organisms</subject><subject>Aquatic Pollution</subject><subject>Atmospheric Protection/Air Quality Control/Air Pollution</subject><subject>Bioaccumulation</subject><subject>Blood</subject><subject>Brain</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Carp</subject><subject>Carps - metabolism</subject><subject>Cyprinidae</subject><subject>Cyprinus carpio</subject><subject>Dose-Response Relationship, Drug</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Environmental science</subject><subject>Enzymes</subject><subject>Exposure</subject><subject>Fish</subject><subject>Fish Proteins - genetics</subject><subject>Fish Proteins - metabolism</subject><subject>Fungicides</subject><subject>Fungicides, Industrial - toxicity</subject><subject>Mancozeb</subject><subject>Maneb - toxicity</subject><subject>Manganese</subject><subject>Manganese - metabolism</subject><subject>Neurotoxicity</subject><subject>NF-E2-Related Factor 2 - genetics</subject><subject>NF-E2-Related Factor 2 - metabolism</subject><subject>Oxidative stress</subject><subject>Reactive oxygen species</subject><subject>Research Article</subject><subject>Rodents</subject><subject>Superoxide dismutase</subject><subject>Toxicity</subject><subject>Waste Water Technology</subject><subject>Water Management</subject><subject>Water Pollutants, Chemical - toxicity</subject><subject>Water Pollution Control</subject><subject>Zineb - toxicity</subject><issn>0944-1344</issn><issn>1614-7499</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kctu1TAQhi0EoofCA7BBltiwMfUtcbxER9ykUjawtsaXlFSJHexYankAnrs-PQUkpK7GHn3_Px7_CL1k9C2jVJ0VxkTXE8oGwhSXRD9CO9YzSZTU-jHaUS0lYULKE_SslCtKOdVcPUUnXHe95lTs0O8vEF36FSwO12sqNQecQ6nzVvAU8QLxEmIoAYNzdakzbFOKGKLHF3nkJIfWCb41Wv968q0e5GuKJdwZbD8CthnaKY3YpWVpagd5xfubNU-xlrvblJ6jJyPMJby4r6fo-4f33_afyPnXj5_3786Jk5JvBHRQbFDgqASQnivuwbNx6Bh4S63lzna2B2dVA2XvNQUxjAO3QYPtBBen6M3Rd83pZw1lM8tUXJjntmWqxXA6SCoUlaqhr_9Dr1LNsb2uUawflJCiaxQ7Ui6nUnIYTdtrgXxjGDWHkMwxJNNCMoeQjG6aV_fO1S7B_1X8SaUB_AiUwyddhvxv9MOut5Z6n3A</recordid><startdate>20180601</startdate><enddate>20180601</enddate><creator>Costa-Silva, Dennis Guilherme</creator><creator>Lopes, Andressa Rubim</creator><creator>Martins, Illana Kemmerich</creator><creator>Leandro, Luana Paganotto</creator><creator>Nunes, Mauro Eugênio Medina</creator><creator>de Carvalho, Nelson Rodrigues</creator><creator>Rodrigues, Nathane Rosa</creator><creator>Macedo, Giulianna Echeveria</creator><creator>Saidelles, Ana Paula</creator><creator>Aguiar, Cassiana</creator><creator>Doneda, Morgana</creator><creator>Flores, Erico Marlon Moraes</creator><creator>Posser, Thais</creator><creator>Franco, Jeferson Luis</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7SN</scope><scope>7T7</scope><scope>7TV</scope><scope>7U7</scope><scope>7WY</scope><scope>7WZ</scope><scope>7X7</scope><scope>7XB</scope><scope>87Z</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FL</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FRNLG</scope><scope>FYUFA</scope><scope>F~G</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K60</scope><scope>K6~</scope><scope>K9.</scope><scope>L.-</scope><scope>M0C</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>P64</scope><scope>PATMY</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0002-3874-8618</orcidid></search><sort><creationdate>20180601</creationdate><title>Mancozeb exposure results in manganese accumulation and Nrf2-related antioxidant responses in the brain of common carp Cyprinus carpio</title><author>Costa-Silva, Dennis Guilherme ; Lopes, Andressa Rubim ; Martins, Illana Kemmerich ; Leandro, Luana Paganotto ; Nunes, Mauro Eugênio Medina ; de Carvalho, Nelson Rodrigues ; Rodrigues, Nathane Rosa ; Macedo, Giulianna Echeveria ; Saidelles, Ana Paula ; Aguiar, Cassiana ; Doneda, Morgana ; Flores, Erico Marlon Moraes ; Posser, Thais ; Franco, Jeferson Luis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-a9e7187ac04aa4d272dad1f851adb0bb2cb5b6acb79e746d90a38f82be9ab5323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Activation</topic><topic>Animals</topic><topic>Antioxidants</topic><topic>Antioxidants - metabolism</topic><topic>Aquatic organisms</topic><topic>Aquatic Pollution</topic><topic>Atmospheric Protection/Air Quality Control/Air Pollution</topic><topic>Bioaccumulation</topic><topic>Blood</topic><topic>Brain</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Carp</topic><topic>Carps - metabolism</topic><topic>Cyprinidae</topic><topic>Cyprinus carpio</topic><topic>Dose-Response Relationship, Drug</topic><topic>Earth and Environmental Science</topic><topic>Ecotoxicology</topic><topic>Environment</topic><topic>Environmental Chemistry</topic><topic>Environmental Health</topic><topic>Environmental science</topic><topic>Enzymes</topic><topic>Exposure</topic><topic>Fish</topic><topic>Fish Proteins - genetics</topic><topic>Fish Proteins - metabolism</topic><topic>Fungicides</topic><topic>Fungicides, Industrial - toxicity</topic><topic>Mancozeb</topic><topic>Maneb - toxicity</topic><topic>Manganese</topic><topic>Manganese - metabolism</topic><topic>Neurotoxicity</topic><topic>NF-E2-Related Factor 2 - 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Academic</collection><jtitle>Environmental science and pollution research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Costa-Silva, Dennis Guilherme</au><au>Lopes, Andressa Rubim</au><au>Martins, Illana Kemmerich</au><au>Leandro, Luana Paganotto</au><au>Nunes, Mauro Eugênio Medina</au><au>de Carvalho, Nelson Rodrigues</au><au>Rodrigues, Nathane Rosa</au><au>Macedo, Giulianna Echeveria</au><au>Saidelles, Ana Paula</au><au>Aguiar, Cassiana</au><au>Doneda, Morgana</au><au>Flores, Erico Marlon Moraes</au><au>Posser, Thais</au><au>Franco, Jeferson Luis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mancozeb exposure results in manganese accumulation and Nrf2-related antioxidant responses in the brain of common carp Cyprinus carpio</atitle><jtitle>Environmental science and pollution research international</jtitle><stitle>Environ Sci Pollut Res</stitle><addtitle>Environ Sci Pollut Res Int</addtitle><date>2018-06-01</date><risdate>2018</risdate><volume>25</volume><issue>16</issue><spage>15529</spage><epage>15540</epage><pages>15529-15540</pages><issn>0944-1344</issn><eissn>1614-7499</eissn><abstract>Manganese (Mn)-containing dithiocarbamates such as Mancozeb (MZ) have been shown to induce oxidative stress-related toxicity in rodents and humans. However, little is known about the neurotoxic effects induced by MZ in fish. In this study, carp (
Cyprinus carpio
) were exposed to non-lethal waterborne concentrations of MZ, and oxidative stress parameters as well as metal accumulation in fish brains were evaluated. The experimental groups were as follows: control, MZ 5 mg/L, and MZ 10 mg/L. Fish were exposed for 7 days, and then brain was removed and prepared for subsequent analysis of antioxidant enzymes, reactive oxygen species (ROS), and expression of Nrf2 and phosphoNrf2. In parallel, manganese (Mn) levels were evaluated in blood and brain tissues. Mn levels were significantly increased in blood and brain of MZ-exposed carps. In addition, a concentration-dependent increase (
p
< 0.05) in ROS levels was observed in parallel to increments (
p
< 0.05) in the activity of major antioxidant enzymes, such as GPx, GR, and GST. On the other hand, significant decreases (
p
< 0.05) in CAT and SOD activities were observed. The expression of total and phosphorylated forms of Nrf2 was significantly (
p
< 0.05) upregulated in the brain of carps exposed to Mz when compared to the control, indicating an activation of the Nrf2 antioxidant pathway. Our study showed for the first time the activation of the Nrf2/ARE pathway and bioaccumulation of Mn induced by MZ exposure in fish species, highlighting important mechanisms of action and its toxicological impacts to aquatic organisms.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>29569203</pmid><doi>10.1007/s11356-018-1724-9</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-3874-8618</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0944-1344 |
| ispartof | Environmental science and pollution research international, 2018-06, Vol.25 (16), p.15529-15540 |
| issn | 0944-1344 1614-7499 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2084037047 |
| source | MEDLINE; Springer Journals |
| subjects | Activation Animals Antioxidants Antioxidants - metabolism Aquatic organisms Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Bioaccumulation Blood Brain Brain - drug effects Brain - metabolism Carp Carps - metabolism Cyprinidae Cyprinus carpio Dose-Response Relationship, Drug Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Health Environmental science Enzymes Exposure Fish Fish Proteins - genetics Fish Proteins - metabolism Fungicides Fungicides, Industrial - toxicity Mancozeb Maneb - toxicity Manganese Manganese - metabolism Neurotoxicity NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Oxidative stress Reactive oxygen species Research Article Rodents Superoxide dismutase Toxicity Waste Water Technology Water Management Water Pollutants, Chemical - toxicity Water Pollution Control Zineb - toxicity |
| title | Mancozeb exposure results in manganese accumulation and Nrf2-related antioxidant responses in the brain of common carp Cyprinus carpio |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T18%3A09%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Mancozeb%20exposure%20results%20in%20manganese%20accumulation%20and%20Nrf2-related%20antioxidant%20responses%20in%20the%20brain%20of%20common%20carp%20Cyprinus%20carpio&rft.jtitle=Environmental%20science%20and%20pollution%20research%20international&rft.au=Costa-Silva,%20Dennis%20Guilherme&rft.date=2018-06-01&rft.volume=25&rft.issue=16&rft.spage=15529&rft.epage=15540&rft.pages=15529-15540&rft.issn=0944-1344&rft.eissn=1614-7499&rft_id=info:doi/10.1007/s11356-018-1724-9&rft_dat=%3Cproquest_cross%3E2084037047%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2016873435&rft_id=info:pmid/29569203&rfr_iscdi=true |