6-Methylapigenin and hesperidin: new valeriana flavonoids with activity on the CNS
Valerian is an ancient tranquillizing drug obtained from the underground organs of several Valeriana species. Its active principles were assumed to be terpenoids in the form of valepotriates and/or as components of the essential oil. However, unknown active compounds were not discarded and synergic...
Gespeichert in:
| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 2003-06, Vol.75 (3), p.537-545 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 545 |
|---|---|
| container_issue | 3 |
| container_start_page | 537 |
| container_title | Pharmacology, biochemistry and behavior |
| container_volume | 75 |
| creator | Marder, Mariel Viola, Haydeé Wasowski, Cristina Fernández, Sebastián Medina, Jorge H Paladini, Alejandro C |
| description | Valerian is an ancient tranquillizing drug obtained from the underground organs of several
Valeriana species. Its active principles were assumed to be terpenoids in the form of valepotriates and/or as components of the essential oil. However, unknown active compounds were not discarded and synergic effects were suspected.
We have recently isolated 6-methylapigenin (MA) from
Valeriana wallichii and proved that it is a benzodiazepine binding site (BDZ-bs) ligand [Planta Med. 68 (2002) 934].
The present paper is the first report of the presence of 2
S(−)-hesperidin in valeriana and describes that it has sedative and sleep-enhancing properties. MA, in turn, was found to have anxiolytic properties and was able to potentiate the sleep-enhancing properties of hesperidin (HN).
MA and HN are new members of the growing family of natural flavonoids with activity on the CNS, and their properties suggest that they are promising drug leads in the field. |
| doi_str_mv | 10.1016/S0091-3057(03)00121-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_20839404</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0091305703001217</els_id><sourcerecordid>20839404</sourcerecordid><originalsourceid>FETCH-LOGICAL-c444t-40a569f070a9c2b8cce172ba32e7861960d390a88fad4e48c144dcd19d9dbff53</originalsourceid><addsrcrecordid>eNqFkMtOwzAQRS0EoqXwCSCvECwC48SJYzYIVbwkHhKFteXaE2qUOiVOU_XvSR-CJavRSOfO1RxCjhlcMGDZ5QhAsiiBVJxBcg7AYhaJHdJnuUiilAmxS_q_SI8chPAFADzOxD7psTiXaSZYn7xl0TM2k2WpZ-4TvfNUe0snGGZYO-v8FfW4oK0uu1V7TYtSt5WvnA104ZoJ1aZxrWuWtPK0mSAdvowOyV6hy4BH2zkgH3e378OH6On1_nF48xQZznkTcdBpJgsQoKWJx7kxyEQ81kmMIs-YzMAmEnSeF9py5LlhnFtjmbTSjosiTQbkdHN3VlffcwyNmrpgsCy1x2oeVAx5IjnwDkw3oKmrEGos1Kx2U10vFQO1kqnWMtXKlIJErWUq0eVOtgXz8RTtX2prrwOuNwB2b7YOaxWMQ2_QuhpNo2zl_qn4AXzng_M</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20839404</pqid></control><display><type>article</type><title>6-Methylapigenin and hesperidin: new valeriana flavonoids with activity on the CNS</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Marder, Mariel ; Viola, Haydeé ; Wasowski, Cristina ; Fernández, Sebastián ; Medina, Jorge H ; Paladini, Alejandro C</creator><creatorcontrib>Marder, Mariel ; Viola, Haydeé ; Wasowski, Cristina ; Fernández, Sebastián ; Medina, Jorge H ; Paladini, Alejandro C</creatorcontrib><description>Valerian is an ancient tranquillizing drug obtained from the underground organs of several
Valeriana species. Its active principles were assumed to be terpenoids in the form of valepotriates and/or as components of the essential oil. However, unknown active compounds were not discarded and synergic effects were suspected.
We have recently isolated 6-methylapigenin (MA) from
Valeriana wallichii and proved that it is a benzodiazepine binding site (BDZ-bs) ligand [Planta Med. 68 (2002) 934].
The present paper is the first report of the presence of 2
S(−)-hesperidin in valeriana and describes that it has sedative and sleep-enhancing properties. MA, in turn, was found to have anxiolytic properties and was able to potentiate the sleep-enhancing properties of hesperidin (HN).
MA and HN are new members of the growing family of natural flavonoids with activity on the CNS, and their properties suggest that they are promising drug leads in the field.</description><identifier>ISSN: 0091-3057</identifier><identifier>EISSN: 1873-5177</identifier><identifier>DOI: 10.1016/S0091-3057(03)00121-7</identifier><identifier>PMID: 12895671</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>6-Methylapigenin ; Animals ; Anxiolysis ; Benzodiazepine binding site ; Central Nervous System Agents - chemistry ; Central Nervous System Agents - pharmacology ; Central Nervous System Agents - therapeutic use ; CNS ; Dose-Response Relationship, Drug ; Drug Synergism ; Flavonoids ; Flavonoids - chemistry ; Flavonoids - pharmacology ; Flavonoids - therapeutic use ; GABA A receptor ; Hesperidin ; Hesperidin - chemistry ; Hesperidin - pharmacology ; Hesperidin - therapeutic use ; Hypnosis ; Male ; Mice ; Motor Activity - drug effects ; Motor Activity - physiology ; Phytotherapy - methods ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Plant Roots ; Rats ; Rats, Wistar ; Rhizome ; Sedation ; Sleep - drug effects ; Sleep - physiology ; Valerian ; Valeriana</subject><ispartof>Pharmacology, biochemistry and behavior, 2003-06, Vol.75 (3), p.537-545</ispartof><rights>2003 Elsevier Science Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-40a569f070a9c2b8cce172ba32e7861960d390a88fad4e48c144dcd19d9dbff53</citedby><cites>FETCH-LOGICAL-c444t-40a569f070a9c2b8cce172ba32e7861960d390a88fad4e48c144dcd19d9dbff53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0091-3057(03)00121-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12895671$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marder, Mariel</creatorcontrib><creatorcontrib>Viola, Haydeé</creatorcontrib><creatorcontrib>Wasowski, Cristina</creatorcontrib><creatorcontrib>Fernández, Sebastián</creatorcontrib><creatorcontrib>Medina, Jorge H</creatorcontrib><creatorcontrib>Paladini, Alejandro C</creatorcontrib><title>6-Methylapigenin and hesperidin: new valeriana flavonoids with activity on the CNS</title><title>Pharmacology, biochemistry and behavior</title><addtitle>Pharmacol Biochem Behav</addtitle><description>Valerian is an ancient tranquillizing drug obtained from the underground organs of several
Valeriana species. Its active principles were assumed to be terpenoids in the form of valepotriates and/or as components of the essential oil. However, unknown active compounds were not discarded and synergic effects were suspected.
We have recently isolated 6-methylapigenin (MA) from
Valeriana wallichii and proved that it is a benzodiazepine binding site (BDZ-bs) ligand [Planta Med. 68 (2002) 934].
The present paper is the first report of the presence of 2
S(−)-hesperidin in valeriana and describes that it has sedative and sleep-enhancing properties. MA, in turn, was found to have anxiolytic properties and was able to potentiate the sleep-enhancing properties of hesperidin (HN).
MA and HN are new members of the growing family of natural flavonoids with activity on the CNS, and their properties suggest that they are promising drug leads in the field.</description><subject>6-Methylapigenin</subject><subject>Animals</subject><subject>Anxiolysis</subject><subject>Benzodiazepine binding site</subject><subject>Central Nervous System Agents - chemistry</subject><subject>Central Nervous System Agents - pharmacology</subject><subject>Central Nervous System Agents - therapeutic use</subject><subject>CNS</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Synergism</subject><subject>Flavonoids</subject><subject>Flavonoids - chemistry</subject><subject>Flavonoids - pharmacology</subject><subject>Flavonoids - therapeutic use</subject><subject>GABA A receptor</subject><subject>Hesperidin</subject><subject>Hesperidin - chemistry</subject><subject>Hesperidin - pharmacology</subject><subject>Hesperidin - therapeutic use</subject><subject>Hypnosis</subject><subject>Male</subject><subject>Mice</subject><subject>Motor Activity - drug effects</subject><subject>Motor Activity - physiology</subject><subject>Phytotherapy - methods</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Roots</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rhizome</subject><subject>Sedation</subject><subject>Sleep - drug effects</subject><subject>Sleep - physiology</subject><subject>Valerian</subject><subject>Valeriana</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOwzAQRS0EoqXwCSCvECwC48SJYzYIVbwkHhKFteXaE2qUOiVOU_XvSR-CJavRSOfO1RxCjhlcMGDZ5QhAsiiBVJxBcg7AYhaJHdJnuUiilAmxS_q_SI8chPAFADzOxD7psTiXaSZYn7xl0TM2k2WpZ-4TvfNUe0snGGZYO-v8FfW4oK0uu1V7TYtSt5WvnA104ZoJ1aZxrWuWtPK0mSAdvowOyV6hy4BH2zkgH3e378OH6On1_nF48xQZznkTcdBpJgsQoKWJx7kxyEQ81kmMIs-YzMAmEnSeF9py5LlhnFtjmbTSjosiTQbkdHN3VlffcwyNmrpgsCy1x2oeVAx5IjnwDkw3oKmrEGos1Kx2U10vFQO1kqnWMtXKlIJErWUq0eVOtgXz8RTtX2prrwOuNwB2b7YOaxWMQ2_QuhpNo2zl_qn4AXzng_M</recordid><startdate>20030601</startdate><enddate>20030601</enddate><creator>Marder, Mariel</creator><creator>Viola, Haydeé</creator><creator>Wasowski, Cristina</creator><creator>Fernández, Sebastián</creator><creator>Medina, Jorge H</creator><creator>Paladini, Alejandro C</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope></search><sort><creationdate>20030601</creationdate><title>6-Methylapigenin and hesperidin: new valeriana flavonoids with activity on the CNS</title><author>Marder, Mariel ; Viola, Haydeé ; Wasowski, Cristina ; Fernández, Sebastián ; Medina, Jorge H ; Paladini, Alejandro C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-40a569f070a9c2b8cce172ba32e7861960d390a88fad4e48c144dcd19d9dbff53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>6-Methylapigenin</topic><topic>Animals</topic><topic>Anxiolysis</topic><topic>Benzodiazepine binding site</topic><topic>Central Nervous System Agents - chemistry</topic><topic>Central Nervous System Agents - pharmacology</topic><topic>Central Nervous System Agents - therapeutic use</topic><topic>CNS</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Synergism</topic><topic>Flavonoids</topic><topic>Flavonoids - chemistry</topic><topic>Flavonoids - pharmacology</topic><topic>Flavonoids - therapeutic use</topic><topic>GABA A receptor</topic><topic>Hesperidin</topic><topic>Hesperidin - chemistry</topic><topic>Hesperidin - pharmacology</topic><topic>Hesperidin - therapeutic use</topic><topic>Hypnosis</topic><topic>Male</topic><topic>Mice</topic><topic>Motor Activity - drug effects</topic><topic>Motor Activity - physiology</topic><topic>Phytotherapy - methods</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plant Roots</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rhizome</topic><topic>Sedation</topic><topic>Sleep - drug effects</topic><topic>Sleep - physiology</topic><topic>Valerian</topic><topic>Valeriana</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marder, Mariel</creatorcontrib><creatorcontrib>Viola, Haydeé</creatorcontrib><creatorcontrib>Wasowski, Cristina</creatorcontrib><creatorcontrib>Fernández, Sebastián</creatorcontrib><creatorcontrib>Medina, Jorge H</creatorcontrib><creatorcontrib>Paladini, Alejandro C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marder, Mariel</au><au>Viola, Haydeé</au><au>Wasowski, Cristina</au><au>Fernández, Sebastián</au><au>Medina, Jorge H</au><au>Paladini, Alejandro C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>6-Methylapigenin and hesperidin: new valeriana flavonoids with activity on the CNS</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>2003-06-01</date><risdate>2003</risdate><volume>75</volume><issue>3</issue><spage>537</spage><epage>545</epage><pages>537-545</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><abstract>Valerian is an ancient tranquillizing drug obtained from the underground organs of several
Valeriana species. Its active principles were assumed to be terpenoids in the form of valepotriates and/or as components of the essential oil. However, unknown active compounds were not discarded and synergic effects were suspected.
We have recently isolated 6-methylapigenin (MA) from
Valeriana wallichii and proved that it is a benzodiazepine binding site (BDZ-bs) ligand [Planta Med. 68 (2002) 934].
The present paper is the first report of the presence of 2
S(−)-hesperidin in valeriana and describes that it has sedative and sleep-enhancing properties. MA, in turn, was found to have anxiolytic properties and was able to potentiate the sleep-enhancing properties of hesperidin (HN).
MA and HN are new members of the growing family of natural flavonoids with activity on the CNS, and their properties suggest that they are promising drug leads in the field.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>12895671</pmid><doi>10.1016/S0091-3057(03)00121-7</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0091-3057 |
| ispartof | Pharmacology, biochemistry and behavior, 2003-06, Vol.75 (3), p.537-545 |
| issn | 0091-3057 1873-5177 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_20839404 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | 6-Methylapigenin Animals Anxiolysis Benzodiazepine binding site Central Nervous System Agents - chemistry Central Nervous System Agents - pharmacology Central Nervous System Agents - therapeutic use CNS Dose-Response Relationship, Drug Drug Synergism Flavonoids Flavonoids - chemistry Flavonoids - pharmacology Flavonoids - therapeutic use GABA A receptor Hesperidin Hesperidin - chemistry Hesperidin - pharmacology Hesperidin - therapeutic use Hypnosis Male Mice Motor Activity - drug effects Motor Activity - physiology Phytotherapy - methods Plant Extracts - chemistry Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Roots Rats Rats, Wistar Rhizome Sedation Sleep - drug effects Sleep - physiology Valerian Valeriana |
| title | 6-Methylapigenin and hesperidin: new valeriana flavonoids with activity on the CNS |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T16%3A31%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=6-Methylapigenin%20and%20hesperidin:%20new%20valeriana%20flavonoids%20with%20activity%20on%20the%20CNS&rft.jtitle=Pharmacology,%20biochemistry%20and%20behavior&rft.au=Marder,%20Mariel&rft.date=2003-06-01&rft.volume=75&rft.issue=3&rft.spage=537&rft.epage=545&rft.pages=537-545&rft.issn=0091-3057&rft.eissn=1873-5177&rft_id=info:doi/10.1016/S0091-3057(03)00121-7&rft_dat=%3Cproquest_cross%3E20839404%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=20839404&rft_id=info:pmid/12895671&rft_els_id=S0091305703001217&rfr_iscdi=true |