Demethoxycurcumin: A naturally occurring curcumin analogue with antitumor properties

The eradication of cancer in a patient remains an elusive challenge despite advances in early detection and diagnosis, chemo‐ and immunotherapy, pinpoint radiation treatments, and expert surgical intervention. Although significant gains have been made in our understanding of cancer cell biology, a d...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of cellular physiology 2018-12, Vol.233 (12), p.9247-9260
Hauptverfasser: Hatamipour, Mahdi, Ramezani, Mahin, Tabassi, Sayyed Abolghasem Sajadi, Johnston, Thomas P., Ramezani, Mahnaz, Sahebkar, Amirhosein
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 9260
container_issue 12
container_start_page 9247
container_title Journal of cellular physiology
container_volume 233
creator Hatamipour, Mahdi
Ramezani, Mahin
Tabassi, Sayyed Abolghasem Sajadi
Johnston, Thomas P.
Ramezani, Mahnaz
Sahebkar, Amirhosein
description The eradication of cancer in a patient remains an elusive challenge despite advances in early detection and diagnosis, chemo‐ and immunotherapy, pinpoint radiation treatments, and expert surgical intervention. Although significant gains have been made in our understanding of cancer cell biology, a definite cure for most cancers does not exist at present. Thus, it is not surprising that the research and medical communities continue to explore the importance and therapeutic potential of natural products in their multimodality cancer treatment approach. Curcuminoids found in turmeric are one such class of natural products that have been extensively investigated for their potential to halt the progression of cancer cell proliferation and, more important, to stop metastasis from occurring. In this review, we examine one curcuminoid (demethoxycurcumin [DMC]) largely because of its increased stability and better aqueous solubility at physiological pH, unlike the more well‐known curcuminoid (curcumin), which is largely unabsorbed after oral ingestion. The present review will focus on the signaling pathways that DMC utilizes to modulate the growth, invasion, and metastasis of cancer cells in an effort to provide enhanced mechanistic insight into DMC’s action as it pertains to brain, ovarian, breast, lung, skin, and prostate cancer. Additionally, this review will attempt to provide an overview of DMC’s mechanism of action by modulating apoptosis, cell cycle, angiogenesis, metastasis, and chemosensitivity. Lastly, it is hoped that increased understanding will be gained concerning DMC’s interactive role with microRNA‐551a, 5′ adenosine monophosphate‐activated protein kinase, nuclear factor‐κB, Wnt inhibitory factor‐1, and heat shock protein 70 to affect the progression of cancer. In this review, we present the available evidence on the antitumor activity of demethoxycurcumin (DMC) in different types of tumors and discuss the molecular mechanisms underlying DMC’s antitumor activity.
doi_str_mv 10.1002/jcp.27029
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2083708970</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2118441455</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3539-33b64029146e45aa9f5aafad8b8df06c794e0a168e4a93a087f053005f932df13</originalsourceid><addsrcrecordid>eNp1kE1PwzAMhiMEYmNw4A-gSlzgUOY0adNwm8a3JsFhnKusTbZObTOSRqP_nkA3DkhcbNl-9Np-ETrHcIMBovE639xEDCJ-gIYYOAtpEkeHaOhnOOQxxQN0Yu0aADgn5BgNCABLWMSGaH4na9mu9GeXO5O7umxug0nQiNYZUVVdoHPfN2WzDPbzQDSi0ksng23ZrnzVlq2rtQk2Rm-kaUtpT9GREpWVZ7s8Qu8P9_PpUzh7fXyeTmZhTmLCQ0IWCfVXY5pIGgvBlQ9KFOkiLRQkOeNUgsBJKqngREDKFMT-9FhxEhUKkxG66nX96g8nbZvVpc1lVYlGamezCFLCIOUMPHr5B11rZ_wnnsI4pRTTOPbUdU_lRltrpMo2pqyF6TIM2bfVmbc6-7Hasxc7RbeoZfFL7r31wLgHtmUlu_-VspfpWy_5Ba2viDM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2118441455</pqid></control><display><type>article</type><title>Demethoxycurcumin: A naturally occurring curcumin analogue with antitumor properties</title><source>Wiley Journals</source><creator>Hatamipour, Mahdi ; Ramezani, Mahin ; Tabassi, Sayyed Abolghasem Sajadi ; Johnston, Thomas P. ; Ramezani, Mahnaz ; Sahebkar, Amirhosein</creator><creatorcontrib>Hatamipour, Mahdi ; Ramezani, Mahin ; Tabassi, Sayyed Abolghasem Sajadi ; Johnston, Thomas P. ; Ramezani, Mahnaz ; Sahebkar, Amirhosein</creatorcontrib><description>The eradication of cancer in a patient remains an elusive challenge despite advances in early detection and diagnosis, chemo‐ and immunotherapy, pinpoint radiation treatments, and expert surgical intervention. Although significant gains have been made in our understanding of cancer cell biology, a definite cure for most cancers does not exist at present. Thus, it is not surprising that the research and medical communities continue to explore the importance and therapeutic potential of natural products in their multimodality cancer treatment approach. Curcuminoids found in turmeric are one such class of natural products that have been extensively investigated for their potential to halt the progression of cancer cell proliferation and, more important, to stop metastasis from occurring. In this review, we examine one curcuminoid (demethoxycurcumin [DMC]) largely because of its increased stability and better aqueous solubility at physiological pH, unlike the more well‐known curcuminoid (curcumin), which is largely unabsorbed after oral ingestion. The present review will focus on the signaling pathways that DMC utilizes to modulate the growth, invasion, and metastasis of cancer cells in an effort to provide enhanced mechanistic insight into DMC’s action as it pertains to brain, ovarian, breast, lung, skin, and prostate cancer. Additionally, this review will attempt to provide an overview of DMC’s mechanism of action by modulating apoptosis, cell cycle, angiogenesis, metastasis, and chemosensitivity. Lastly, it is hoped that increased understanding will be gained concerning DMC’s interactive role with microRNA‐551a, 5′ adenosine monophosphate‐activated protein kinase, nuclear factor‐κB, Wnt inhibitory factor‐1, and heat shock protein 70 to affect the progression of cancer. In this review, we present the available evidence on the antitumor activity of demethoxycurcumin (DMC) in different types of tumors and discuss the molecular mechanisms underlying DMC’s antitumor activity.</description><identifier>ISSN: 0021-9541</identifier><identifier>EISSN: 1097-4652</identifier><identifier>DOI: 10.1002/jcp.27029</identifier><identifier>PMID: 30076727</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adenosine kinase ; Adenosine monophosphate ; AMP ; Angiogenesis ; Anticancer properties ; Apoptosis ; Brain ; cancer ; Cancer therapies ; Cell cycle ; Cell proliferation ; Curcumin ; curcuminoids ; demethoxycurcumin ; Heat shock factors ; Heat shock proteins ; Hsp70 protein ; Immunotherapy ; Ingestion ; Kinases ; Lung cancer ; Medical research ; Metastases ; Metastasis ; miRNA ; Natural products ; Prostate cancer ; Protein kinase ; Ribonucleic acid ; RNA ; Skin ; Wnt protein</subject><ispartof>Journal of cellular physiology, 2018-12, Vol.233 (12), p.9247-9260</ispartof><rights>2018 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3539-33b64029146e45aa9f5aafad8b8df06c794e0a168e4a93a087f053005f932df13</citedby><cites>FETCH-LOGICAL-c3539-33b64029146e45aa9f5aafad8b8df06c794e0a168e4a93a087f053005f932df13</cites><orcidid>0000-0002-8656-1444</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjcp.27029$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjcp.27029$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30076727$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hatamipour, Mahdi</creatorcontrib><creatorcontrib>Ramezani, Mahin</creatorcontrib><creatorcontrib>Tabassi, Sayyed Abolghasem Sajadi</creatorcontrib><creatorcontrib>Johnston, Thomas P.</creatorcontrib><creatorcontrib>Ramezani, Mahnaz</creatorcontrib><creatorcontrib>Sahebkar, Amirhosein</creatorcontrib><title>Demethoxycurcumin: A naturally occurring curcumin analogue with antitumor properties</title><title>Journal of cellular physiology</title><addtitle>J Cell Physiol</addtitle><description>The eradication of cancer in a patient remains an elusive challenge despite advances in early detection and diagnosis, chemo‐ and immunotherapy, pinpoint radiation treatments, and expert surgical intervention. Although significant gains have been made in our understanding of cancer cell biology, a definite cure for most cancers does not exist at present. Thus, it is not surprising that the research and medical communities continue to explore the importance and therapeutic potential of natural products in their multimodality cancer treatment approach. Curcuminoids found in turmeric are one such class of natural products that have been extensively investigated for their potential to halt the progression of cancer cell proliferation and, more important, to stop metastasis from occurring. In this review, we examine one curcuminoid (demethoxycurcumin [DMC]) largely because of its increased stability and better aqueous solubility at physiological pH, unlike the more well‐known curcuminoid (curcumin), which is largely unabsorbed after oral ingestion. The present review will focus on the signaling pathways that DMC utilizes to modulate the growth, invasion, and metastasis of cancer cells in an effort to provide enhanced mechanistic insight into DMC’s action as it pertains to brain, ovarian, breast, lung, skin, and prostate cancer. Additionally, this review will attempt to provide an overview of DMC’s mechanism of action by modulating apoptosis, cell cycle, angiogenesis, metastasis, and chemosensitivity. Lastly, it is hoped that increased understanding will be gained concerning DMC’s interactive role with microRNA‐551a, 5′ adenosine monophosphate‐activated protein kinase, nuclear factor‐κB, Wnt inhibitory factor‐1, and heat shock protein 70 to affect the progression of cancer. In this review, we present the available evidence on the antitumor activity of demethoxycurcumin (DMC) in different types of tumors and discuss the molecular mechanisms underlying DMC’s antitumor activity.</description><subject>Adenosine kinase</subject><subject>Adenosine monophosphate</subject><subject>AMP</subject><subject>Angiogenesis</subject><subject>Anticancer properties</subject><subject>Apoptosis</subject><subject>Brain</subject><subject>cancer</subject><subject>Cancer therapies</subject><subject>Cell cycle</subject><subject>Cell proliferation</subject><subject>Curcumin</subject><subject>curcuminoids</subject><subject>demethoxycurcumin</subject><subject>Heat shock factors</subject><subject>Heat shock proteins</subject><subject>Hsp70 protein</subject><subject>Immunotherapy</subject><subject>Ingestion</subject><subject>Kinases</subject><subject>Lung cancer</subject><subject>Medical research</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>miRNA</subject><subject>Natural products</subject><subject>Prostate cancer</subject><subject>Protein kinase</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>Skin</subject><subject>Wnt protein</subject><issn>0021-9541</issn><issn>1097-4652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kE1PwzAMhiMEYmNw4A-gSlzgUOY0adNwm8a3JsFhnKusTbZObTOSRqP_nkA3DkhcbNl-9Np-ETrHcIMBovE639xEDCJ-gIYYOAtpEkeHaOhnOOQxxQN0Yu0aADgn5BgNCABLWMSGaH4na9mu9GeXO5O7umxug0nQiNYZUVVdoHPfN2WzDPbzQDSi0ksng23ZrnzVlq2rtQk2Rm-kaUtpT9GREpWVZ7s8Qu8P9_PpUzh7fXyeTmZhTmLCQ0IWCfVXY5pIGgvBlQ9KFOkiLRQkOeNUgsBJKqngREDKFMT-9FhxEhUKkxG66nX96g8nbZvVpc1lVYlGamezCFLCIOUMPHr5B11rZ_wnnsI4pRTTOPbUdU_lRltrpMo2pqyF6TIM2bfVmbc6-7Hasxc7RbeoZfFL7r31wLgHtmUlu_-VspfpWy_5Ba2viDM</recordid><startdate>201812</startdate><enddate>201812</enddate><creator>Hatamipour, Mahdi</creator><creator>Ramezani, Mahin</creator><creator>Tabassi, Sayyed Abolghasem Sajadi</creator><creator>Johnston, Thomas P.</creator><creator>Ramezani, Mahnaz</creator><creator>Sahebkar, Amirhosein</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8656-1444</orcidid></search><sort><creationdate>201812</creationdate><title>Demethoxycurcumin: A naturally occurring curcumin analogue with antitumor properties</title><author>Hatamipour, Mahdi ; Ramezani, Mahin ; Tabassi, Sayyed Abolghasem Sajadi ; Johnston, Thomas P. ; Ramezani, Mahnaz ; Sahebkar, Amirhosein</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3539-33b64029146e45aa9f5aafad8b8df06c794e0a168e4a93a087f053005f932df13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adenosine kinase</topic><topic>Adenosine monophosphate</topic><topic>AMP</topic><topic>Angiogenesis</topic><topic>Anticancer properties</topic><topic>Apoptosis</topic><topic>Brain</topic><topic>cancer</topic><topic>Cancer therapies</topic><topic>Cell cycle</topic><topic>Cell proliferation</topic><topic>Curcumin</topic><topic>curcuminoids</topic><topic>demethoxycurcumin</topic><topic>Heat shock factors</topic><topic>Heat shock proteins</topic><topic>Hsp70 protein</topic><topic>Immunotherapy</topic><topic>Ingestion</topic><topic>Kinases</topic><topic>Lung cancer</topic><topic>Medical research</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>miRNA</topic><topic>Natural products</topic><topic>Prostate cancer</topic><topic>Protein kinase</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>Skin</topic><topic>Wnt protein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hatamipour, Mahdi</creatorcontrib><creatorcontrib>Ramezani, Mahin</creatorcontrib><creatorcontrib>Tabassi, Sayyed Abolghasem Sajadi</creatorcontrib><creatorcontrib>Johnston, Thomas P.</creatorcontrib><creatorcontrib>Ramezani, Mahnaz</creatorcontrib><creatorcontrib>Sahebkar, Amirhosein</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cellular physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hatamipour, Mahdi</au><au>Ramezani, Mahin</au><au>Tabassi, Sayyed Abolghasem Sajadi</au><au>Johnston, Thomas P.</au><au>Ramezani, Mahnaz</au><au>Sahebkar, Amirhosein</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Demethoxycurcumin: A naturally occurring curcumin analogue with antitumor properties</atitle><jtitle>Journal of cellular physiology</jtitle><addtitle>J Cell Physiol</addtitle><date>2018-12</date><risdate>2018</risdate><volume>233</volume><issue>12</issue><spage>9247</spage><epage>9260</epage><pages>9247-9260</pages><issn>0021-9541</issn><eissn>1097-4652</eissn><abstract>The eradication of cancer in a patient remains an elusive challenge despite advances in early detection and diagnosis, chemo‐ and immunotherapy, pinpoint radiation treatments, and expert surgical intervention. Although significant gains have been made in our understanding of cancer cell biology, a definite cure for most cancers does not exist at present. Thus, it is not surprising that the research and medical communities continue to explore the importance and therapeutic potential of natural products in their multimodality cancer treatment approach. Curcuminoids found in turmeric are one such class of natural products that have been extensively investigated for their potential to halt the progression of cancer cell proliferation and, more important, to stop metastasis from occurring. In this review, we examine one curcuminoid (demethoxycurcumin [DMC]) largely because of its increased stability and better aqueous solubility at physiological pH, unlike the more well‐known curcuminoid (curcumin), which is largely unabsorbed after oral ingestion. The present review will focus on the signaling pathways that DMC utilizes to modulate the growth, invasion, and metastasis of cancer cells in an effort to provide enhanced mechanistic insight into DMC’s action as it pertains to brain, ovarian, breast, lung, skin, and prostate cancer. Additionally, this review will attempt to provide an overview of DMC’s mechanism of action by modulating apoptosis, cell cycle, angiogenesis, metastasis, and chemosensitivity. Lastly, it is hoped that increased understanding will be gained concerning DMC’s interactive role with microRNA‐551a, 5′ adenosine monophosphate‐activated protein kinase, nuclear factor‐κB, Wnt inhibitory factor‐1, and heat shock protein 70 to affect the progression of cancer. In this review, we present the available evidence on the antitumor activity of demethoxycurcumin (DMC) in different types of tumors and discuss the molecular mechanisms underlying DMC’s antitumor activity.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30076727</pmid><doi>10.1002/jcp.27029</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-8656-1444</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 0021-9541
ispartof Journal of cellular physiology, 2018-12, Vol.233 (12), p.9247-9260
issn 0021-9541
1097-4652
language eng
recordid cdi_proquest_miscellaneous_2083708970
source Wiley Journals
subjects Adenosine kinase
Adenosine monophosphate
AMP
Angiogenesis
Anticancer properties
Apoptosis
Brain
cancer
Cancer therapies
Cell cycle
Cell proliferation
Curcumin
curcuminoids
demethoxycurcumin
Heat shock factors
Heat shock proteins
Hsp70 protein
Immunotherapy
Ingestion
Kinases
Lung cancer
Medical research
Metastases
Metastasis
miRNA
Natural products
Prostate cancer
Protein kinase
Ribonucleic acid
RNA
Skin
Wnt protein
title Demethoxycurcumin: A naturally occurring curcumin analogue with antitumor properties
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T01%3A47%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Demethoxycurcumin:%20A%20naturally%20occurring%20curcumin%20analogue%20with%20antitumor%20properties&rft.jtitle=Journal%20of%20cellular%20physiology&rft.au=Hatamipour,%20Mahdi&rft.date=2018-12&rft.volume=233&rft.issue=12&rft.spage=9247&rft.epage=9260&rft.pages=9247-9260&rft.issn=0021-9541&rft.eissn=1097-4652&rft_id=info:doi/10.1002/jcp.27029&rft_dat=%3Cproquest_cross%3E2118441455%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2118441455&rft_id=info:pmid/30076727&rfr_iscdi=true