Additive manufactured biodegradable poly(glycerol sebacate methacrylate) nerve guidance conduits

[Display omitted] Entubulating devices to repair peripheral nerve injuries are limited in their effectiveness particularly for critical gap injuries. Current clinically used nerve guidance conduits are often simple tubes, far stiffer than that of the native tissue. This study assesses the use of pol...

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Veröffentlicht in:	Acta biomaterialia 2018-09, Vol.78, p.48-63
Hauptverfasser:	Singh, Dharaminder, Harding, Adam J., Albadawi, Emad, Boissonade, Fiona M., Haycock, John W., Claeyssens, Frederik
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Additive manufacturing Animals Astrocytes - drug effects Astrocytes - metabolism Autografts Axons Axons - drug effects Biocompatible Materials - pharmacology Biodegradability Biodegradable elastomer Biodegradable materials Biodegradation Biomaterials Biomedical materials Cells, Cultured Decanoates - pharmacology Degradation Dorsal root ganglia Elastomers Fibula - drug effects Fibula - innervation Ganglia, Spinal - drug effects Ganglia, Spinal - metabolism Glial cells Glycerol Glycerol - analogs & derivatives Glycerol - pharmacology Grooves Guided Tissue Regeneration - methods Injuries Injury prevention Lithography Male Manufacturing Mechanical properties Methacrylates - pharmacology Mice Nerve guidance conduits Nerve guides Nerve Regeneration - drug effects Neuroglia - drug effects Neuroglia - metabolism Neuronal-glial interactions Neurons Neurons - drug effects Neurons - metabolism Pain Peripheral neuropathy Polymers - pharmacology Rats, Wistar Regeneration Repair Spinal cord Substrates Tissue engineering Tubes
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