Additive manufactured biodegradable poly(glycerol sebacate methacrylate) nerve guidance conduits
[Display omitted] Entubulating devices to repair peripheral nerve injuries are limited in their effectiveness particularly for critical gap injuries. Current clinically used nerve guidance conduits are often simple tubes, far stiffer than that of the native tissue. This study assesses the use of pol...
Gespeichert in:
| Veröffentlicht in: | Acta biomaterialia 2018-09, Vol.78, p.48-63 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 63 |
|---|---|
| container_issue | |
| container_start_page | 48 |
| container_title | Acta biomaterialia |
| container_volume | 78 |
| creator | Singh, Dharaminder Harding, Adam J. Albadawi, Emad Boissonade, Fiona M. Haycock, John W. Claeyssens, Frederik |
| description | [Display omitted]
Entubulating devices to repair peripheral nerve injuries are limited in their effectiveness particularly for critical gap injuries. Current clinically used nerve guidance conduits are often simple tubes, far stiffer than that of the native tissue. This study assesses the use of poly(glycerol sebacate methacrylate) (PGSm), a photocurable formulation of the soft biodegradable material, PGS, for peripheral nerve repair. The material was synthesized, the degradation rate and mechanical properties of material were assessed and nerve guidance conduits were structured via stereolithography. In vitro cell studies confirmed PGSm as a supporting substrate for both neuronal and glial cell growth. Ex vivo studies highlight the ability of the cells from a dissociated dorsal root ganglion to grow out and align along the internal topographical grooves of printed nerve guide conduits. In vivo results in a mouse common fibular nerve injury model show regeneration of axons through the PGSm conduit into the distal stump after 21 days. After conduit repair levels of spinal cord glial activation (an indicator for neuropathic pain development) were equivalent to those seen following graft repair. In conclusion, results indicate that PGSm can be structured via additive manufacturing into functional NGCs. This study opens the route of personalized conduit manufacture for nerve injury repair.
This study describes the use of photocurable of Poly(Glycerol Sebacate) (PGS) for light-based additive manufacturing of Nerve Guidance Conduits (NGCs). PGS is a promising flexible biomaterial for soft tissue engineering, and in particular for nerve repair. Its mechanical properties and degradation rate are within the desirable range for use in neuronal applications. The nerve regeneration supported by the PGS NGCs is similar to an autologous nerve transplant, the current gold standard. A second assessment of regeneration is the activation of glial cells within the spinal cord of the tested animals which reveals no significant increase in neuropathic pain by using the NGCs. This study highlights the successful use of a biodegradable additive manufactured NGC for peripheral nerve repair. |
| doi_str_mv | 10.1016/j.actbio.2018.07.055 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2083707663</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1742706118304586</els_id><sourcerecordid>2083707663</sourcerecordid><originalsourceid>FETCH-LOGICAL-c473t-fb7c688ebce9d000fa6517124c760464130bea444580c8ea1b2ac17e703306873</originalsourceid><addsrcrecordid>eNp9kU9LJDEQxYMo6qrfQJYGL3rotvKnk-xFEFl3BcGLnmM6qZ7N0NMZk25hvv1mGN2Dhz2lAr_3qniPkHMKDQUqr5eNdVMXYsOA6gZUA227R46pVrpWrdT7ZVaC1QokPSLfcl4CcE2ZPiRHHEC1nLFj8nrrfZjCO1YrO859sZwT-qr4elwk6203YLWOw-ZyMWwcpjhUGTvr7FQUOP2xLm2G8rmqRkzFZTEHb0eHlYujn8OUT8lBb4eMZx_vCXm5__l897t-fPr1cHf7WDuh-FT3nXJSa-wc_vAA0FvZUkWZcEqCkIJy6NAKIVoNTqOlHbOOKlTAOUit-Am53PmuU3ybMU9mFbLDYbAjxjkbBporUFLygl58QZdxTmO5zjDKqCyp0S0ldpRLMeeEvVmnsLJpYyiYbQNmaXYNmG0DBpQpDRTZ9w_zuVuh_yf6jLwANzsASxrvAZPJLmCJzIeEbjI-hv9v-AvIw5kP</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2121674213</pqid></control><display><type>article</type><title>Additive manufactured biodegradable poly(glycerol sebacate methacrylate) nerve guidance conduits</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Singh, Dharaminder ; Harding, Adam J. ; Albadawi, Emad ; Boissonade, Fiona M. ; Haycock, John W. ; Claeyssens, Frederik</creator><creatorcontrib>Singh, Dharaminder ; Harding, Adam J. ; Albadawi, Emad ; Boissonade, Fiona M. ; Haycock, John W. ; Claeyssens, Frederik</creatorcontrib><description>[Display omitted]
Entubulating devices to repair peripheral nerve injuries are limited in their effectiveness particularly for critical gap injuries. Current clinically used nerve guidance conduits are often simple tubes, far stiffer than that of the native tissue. This study assesses the use of poly(glycerol sebacate methacrylate) (PGSm), a photocurable formulation of the soft biodegradable material, PGS, for peripheral nerve repair. The material was synthesized, the degradation rate and mechanical properties of material were assessed and nerve guidance conduits were structured via stereolithography. In vitro cell studies confirmed PGSm as a supporting substrate for both neuronal and glial cell growth. Ex vivo studies highlight the ability of the cells from a dissociated dorsal root ganglion to grow out and align along the internal topographical grooves of printed nerve guide conduits. In vivo results in a mouse common fibular nerve injury model show regeneration of axons through the PGSm conduit into the distal stump after 21 days. After conduit repair levels of spinal cord glial activation (an indicator for neuropathic pain development) were equivalent to those seen following graft repair. In conclusion, results indicate that PGSm can be structured via additive manufacturing into functional NGCs. This study opens the route of personalized conduit manufacture for nerve injury repair.
This study describes the use of photocurable of Poly(Glycerol Sebacate) (PGS) for light-based additive manufacturing of Nerve Guidance Conduits (NGCs). PGS is a promising flexible biomaterial for soft tissue engineering, and in particular for nerve repair. Its mechanical properties and degradation rate are within the desirable range for use in neuronal applications. The nerve regeneration supported by the PGS NGCs is similar to an autologous nerve transplant, the current gold standard. A second assessment of regeneration is the activation of glial cells within the spinal cord of the tested animals which reveals no significant increase in neuropathic pain by using the NGCs. This study highlights the successful use of a biodegradable additive manufactured NGC for peripheral nerve repair.</description><identifier>ISSN: 1742-7061</identifier><identifier>EISSN: 1878-7568</identifier><identifier>DOI: 10.1016/j.actbio.2018.07.055</identifier><identifier>PMID: 30075322</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Activation ; Additive manufacturing ; Animals ; Astrocytes - drug effects ; Astrocytes - metabolism ; Autografts ; Axons ; Axons - drug effects ; Biocompatible Materials - pharmacology ; Biodegradability ; Biodegradable elastomer ; Biodegradable materials ; Biodegradation ; Biomaterials ; Biomedical materials ; Cells, Cultured ; Decanoates - pharmacology ; Degradation ; Dorsal root ganglia ; Elastomers ; Fibula - drug effects ; Fibula - innervation ; Ganglia, Spinal - drug effects ; Ganglia, Spinal - metabolism ; Glial cells ; Glycerol ; Glycerol - analogs & derivatives ; Glycerol - pharmacology ; Grooves ; Guided Tissue Regeneration - methods ; Injuries ; Injury prevention ; Lithography ; Male ; Manufacturing ; Mechanical properties ; Methacrylates - pharmacology ; Mice ; Nerve guidance conduits ; Nerve guides ; Nerve Regeneration - drug effects ; Neuroglia - drug effects ; Neuroglia - metabolism ; Neuronal-glial interactions ; Neurons ; Neurons - drug effects ; Neurons - metabolism ; Pain ; Peripheral neuropathy ; Polymers - pharmacology ; Rats, Wistar ; Regeneration ; Repair ; Spinal cord ; Substrates ; Tissue engineering ; Tubes</subject><ispartof>Acta biomaterialia, 2018-09, Vol.78, p.48-63</ispartof><rights>2018 Acta Materialia Inc.</rights><rights>Copyright © 2018 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier BV Sep 15, 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c473t-fb7c688ebce9d000fa6517124c760464130bea444580c8ea1b2ac17e703306873</citedby><cites>FETCH-LOGICAL-c473t-fb7c688ebce9d000fa6517124c760464130bea444580c8ea1b2ac17e703306873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1742706118304586$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30075322$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Singh, Dharaminder</creatorcontrib><creatorcontrib>Harding, Adam J.</creatorcontrib><creatorcontrib>Albadawi, Emad</creatorcontrib><creatorcontrib>Boissonade, Fiona M.</creatorcontrib><creatorcontrib>Haycock, John W.</creatorcontrib><creatorcontrib>Claeyssens, Frederik</creatorcontrib><title>Additive manufactured biodegradable poly(glycerol sebacate methacrylate) nerve guidance conduits</title><title>Acta biomaterialia</title><addtitle>Acta Biomater</addtitle><description>[Display omitted]
Entubulating devices to repair peripheral nerve injuries are limited in their effectiveness particularly for critical gap injuries. Current clinically used nerve guidance conduits are often simple tubes, far stiffer than that of the native tissue. This study assesses the use of poly(glycerol sebacate methacrylate) (PGSm), a photocurable formulation of the soft biodegradable material, PGS, for peripheral nerve repair. The material was synthesized, the degradation rate and mechanical properties of material were assessed and nerve guidance conduits were structured via stereolithography. In vitro cell studies confirmed PGSm as a supporting substrate for both neuronal and glial cell growth. Ex vivo studies highlight the ability of the cells from a dissociated dorsal root ganglion to grow out and align along the internal topographical grooves of printed nerve guide conduits. In vivo results in a mouse common fibular nerve injury model show regeneration of axons through the PGSm conduit into the distal stump after 21 days. After conduit repair levels of spinal cord glial activation (an indicator for neuropathic pain development) were equivalent to those seen following graft repair. In conclusion, results indicate that PGSm can be structured via additive manufacturing into functional NGCs. This study opens the route of personalized conduit manufacture for nerve injury repair.
This study describes the use of photocurable of Poly(Glycerol Sebacate) (PGS) for light-based additive manufacturing of Nerve Guidance Conduits (NGCs). PGS is a promising flexible biomaterial for soft tissue engineering, and in particular for nerve repair. Its mechanical properties and degradation rate are within the desirable range for use in neuronal applications. The nerve regeneration supported by the PGS NGCs is similar to an autologous nerve transplant, the current gold standard. A second assessment of regeneration is the activation of glial cells within the spinal cord of the tested animals which reveals no significant increase in neuropathic pain by using the NGCs. This study highlights the successful use of a biodegradable additive manufactured NGC for peripheral nerve repair.</description><subject>Activation</subject><subject>Additive manufacturing</subject><subject>Animals</subject><subject>Astrocytes - drug effects</subject><subject>Astrocytes - metabolism</subject><subject>Autografts</subject><subject>Axons</subject><subject>Axons - drug effects</subject><subject>Biocompatible Materials - pharmacology</subject><subject>Biodegradability</subject><subject>Biodegradable elastomer</subject><subject>Biodegradable materials</subject><subject>Biodegradation</subject><subject>Biomaterials</subject><subject>Biomedical materials</subject><subject>Cells, Cultured</subject><subject>Decanoates - pharmacology</subject><subject>Degradation</subject><subject>Dorsal root ganglia</subject><subject>Elastomers</subject><subject>Fibula - drug effects</subject><subject>Fibula - innervation</subject><subject>Ganglia, Spinal - drug effects</subject><subject>Ganglia, Spinal - metabolism</subject><subject>Glial cells</subject><subject>Glycerol</subject><subject>Glycerol - analogs & derivatives</subject><subject>Glycerol - pharmacology</subject><subject>Grooves</subject><subject>Guided Tissue Regeneration - methods</subject><subject>Injuries</subject><subject>Injury prevention</subject><subject>Lithography</subject><subject>Male</subject><subject>Manufacturing</subject><subject>Mechanical properties</subject><subject>Methacrylates - pharmacology</subject><subject>Mice</subject><subject>Nerve guidance conduits</subject><subject>Nerve guides</subject><subject>Nerve Regeneration - drug effects</subject><subject>Neuroglia - drug effects</subject><subject>Neuroglia - metabolism</subject><subject>Neuronal-glial interactions</subject><subject>Neurons</subject><subject>Neurons - drug effects</subject><subject>Neurons - metabolism</subject><subject>Pain</subject><subject>Peripheral neuropathy</subject><subject>Polymers - pharmacology</subject><subject>Rats, Wistar</subject><subject>Regeneration</subject><subject>Repair</subject><subject>Spinal cord</subject><subject>Substrates</subject><subject>Tissue engineering</subject><subject>Tubes</subject><issn>1742-7061</issn><issn>1878-7568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9LJDEQxYMo6qrfQJYGL3rotvKnk-xFEFl3BcGLnmM6qZ7N0NMZk25hvv1mGN2Dhz2lAr_3qniPkHMKDQUqr5eNdVMXYsOA6gZUA227R46pVrpWrdT7ZVaC1QokPSLfcl4CcE2ZPiRHHEC1nLFj8nrrfZjCO1YrO859sZwT-qr4elwk6203YLWOw-ZyMWwcpjhUGTvr7FQUOP2xLm2G8rmqRkzFZTEHb0eHlYujn8OUT8lBb4eMZx_vCXm5__l897t-fPr1cHf7WDuh-FT3nXJSa-wc_vAA0FvZUkWZcEqCkIJy6NAKIVoNTqOlHbOOKlTAOUit-Am53PmuU3ybMU9mFbLDYbAjxjkbBporUFLygl58QZdxTmO5zjDKqCyp0S0ldpRLMeeEvVmnsLJpYyiYbQNmaXYNmG0DBpQpDRTZ9w_zuVuh_yf6jLwANzsASxrvAZPJLmCJzIeEbjI-hv9v-AvIw5kP</recordid><startdate>20180915</startdate><enddate>20180915</enddate><creator>Singh, Dharaminder</creator><creator>Harding, Adam J.</creator><creator>Albadawi, Emad</creator><creator>Boissonade, Fiona M.</creator><creator>Haycock, John W.</creator><creator>Claeyssens, Frederik</creator><general>Elsevier Ltd</general><general>Elsevier BV</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20180915</creationdate><title>Additive manufactured biodegradable poly(glycerol sebacate methacrylate) nerve guidance conduits</title><author>Singh, Dharaminder ; Harding, Adam J. ; Albadawi, Emad ; Boissonade, Fiona M. ; Haycock, John W. ; Claeyssens, Frederik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c473t-fb7c688ebce9d000fa6517124c760464130bea444580c8ea1b2ac17e703306873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Activation</topic><topic>Additive manufacturing</topic><topic>Animals</topic><topic>Astrocytes - drug effects</topic><topic>Astrocytes - metabolism</topic><topic>Autografts</topic><topic>Axons</topic><topic>Axons - drug effects</topic><topic>Biocompatible Materials - pharmacology</topic><topic>Biodegradability</topic><topic>Biodegradable elastomer</topic><topic>Biodegradable materials</topic><topic>Biodegradation</topic><topic>Biomaterials</topic><topic>Biomedical materials</topic><topic>Cells, Cultured</topic><topic>Decanoates - pharmacology</topic><topic>Degradation</topic><topic>Dorsal root ganglia</topic><topic>Elastomers</topic><topic>Fibula - drug effects</topic><topic>Fibula - innervation</topic><topic>Ganglia, Spinal - drug effects</topic><topic>Ganglia, Spinal - metabolism</topic><topic>Glial cells</topic><topic>Glycerol</topic><topic>Glycerol - analogs & derivatives</topic><topic>Glycerol - pharmacology</topic><topic>Grooves</topic><topic>Guided Tissue Regeneration - methods</topic><topic>Injuries</topic><topic>Injury prevention</topic><topic>Lithography</topic><topic>Male</topic><topic>Manufacturing</topic><topic>Mechanical properties</topic><topic>Methacrylates - pharmacology</topic><topic>Mice</topic><topic>Nerve guidance conduits</topic><topic>Nerve guides</topic><topic>Nerve Regeneration - drug effects</topic><topic>Neuroglia - drug effects</topic><topic>Neuroglia - metabolism</topic><topic>Neuronal-glial interactions</topic><topic>Neurons</topic><topic>Neurons - drug effects</topic><topic>Neurons - metabolism</topic><topic>Pain</topic><topic>Peripheral neuropathy</topic><topic>Polymers - pharmacology</topic><topic>Rats, Wistar</topic><topic>Regeneration</topic><topic>Repair</topic><topic>Spinal cord</topic><topic>Substrates</topic><topic>Tissue engineering</topic><topic>Tubes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Singh, Dharaminder</creatorcontrib><creatorcontrib>Harding, Adam J.</creatorcontrib><creatorcontrib>Albadawi, Emad</creatorcontrib><creatorcontrib>Boissonade, Fiona M.</creatorcontrib><creatorcontrib>Haycock, John W.</creatorcontrib><creatorcontrib>Claeyssens, Frederik</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Acta biomaterialia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Singh, Dharaminder</au><au>Harding, Adam J.</au><au>Albadawi, Emad</au><au>Boissonade, Fiona M.</au><au>Haycock, John W.</au><au>Claeyssens, Frederik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Additive manufactured biodegradable poly(glycerol sebacate methacrylate) nerve guidance conduits</atitle><jtitle>Acta biomaterialia</jtitle><addtitle>Acta Biomater</addtitle><date>2018-09-15</date><risdate>2018</risdate><volume>78</volume><spage>48</spage><epage>63</epage><pages>48-63</pages><issn>1742-7061</issn><eissn>1878-7568</eissn><abstract>[Display omitted]
Entubulating devices to repair peripheral nerve injuries are limited in their effectiveness particularly for critical gap injuries. Current clinically used nerve guidance conduits are often simple tubes, far stiffer than that of the native tissue. This study assesses the use of poly(glycerol sebacate methacrylate) (PGSm), a photocurable formulation of the soft biodegradable material, PGS, for peripheral nerve repair. The material was synthesized, the degradation rate and mechanical properties of material were assessed and nerve guidance conduits were structured via stereolithography. In vitro cell studies confirmed PGSm as a supporting substrate for both neuronal and glial cell growth. Ex vivo studies highlight the ability of the cells from a dissociated dorsal root ganglion to grow out and align along the internal topographical grooves of printed nerve guide conduits. In vivo results in a mouse common fibular nerve injury model show regeneration of axons through the PGSm conduit into the distal stump after 21 days. After conduit repair levels of spinal cord glial activation (an indicator for neuropathic pain development) were equivalent to those seen following graft repair. In conclusion, results indicate that PGSm can be structured via additive manufacturing into functional NGCs. This study opens the route of personalized conduit manufacture for nerve injury repair.
This study describes the use of photocurable of Poly(Glycerol Sebacate) (PGS) for light-based additive manufacturing of Nerve Guidance Conduits (NGCs). PGS is a promising flexible biomaterial for soft tissue engineering, and in particular for nerve repair. Its mechanical properties and degradation rate are within the desirable range for use in neuronal applications. The nerve regeneration supported by the PGS NGCs is similar to an autologous nerve transplant, the current gold standard. A second assessment of regeneration is the activation of glial cells within the spinal cord of the tested animals which reveals no significant increase in neuropathic pain by using the NGCs. This study highlights the successful use of a biodegradable additive manufactured NGC for peripheral nerve repair.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>30075322</pmid><doi>10.1016/j.actbio.2018.07.055</doi><tpages>16</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1742-7061 |
| ispartof | Acta biomaterialia, 2018-09, Vol.78, p.48-63 |
| issn | 1742-7061 1878-7568 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2083707663 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Activation Additive manufacturing Animals Astrocytes - drug effects Astrocytes - metabolism Autografts Axons Axons - drug effects Biocompatible Materials - pharmacology Biodegradability Biodegradable elastomer Biodegradable materials Biodegradation Biomaterials Biomedical materials Cells, Cultured Decanoates - pharmacology Degradation Dorsal root ganglia Elastomers Fibula - drug effects Fibula - innervation Ganglia, Spinal - drug effects Ganglia, Spinal - metabolism Glial cells Glycerol Glycerol - analogs & derivatives Glycerol - pharmacology Grooves Guided Tissue Regeneration - methods Injuries Injury prevention Lithography Male Manufacturing Mechanical properties Methacrylates - pharmacology Mice Nerve guidance conduits Nerve guides Nerve Regeneration - drug effects Neuroglia - drug effects Neuroglia - metabolism Neuronal-glial interactions Neurons Neurons - drug effects Neurons - metabolism Pain Peripheral neuropathy Polymers - pharmacology Rats, Wistar Regeneration Repair Spinal cord Substrates Tissue engineering Tubes |
| title | Additive manufactured biodegradable poly(glycerol sebacate methacrylate) nerve guidance conduits |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T22%3A57%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Additive%20manufactured%20biodegradable%20poly(glycerol%20sebacate%20methacrylate)%20nerve%20guidance%20conduits&rft.jtitle=Acta%20biomaterialia&rft.au=Singh,%20Dharaminder&rft.date=2018-09-15&rft.volume=78&rft.spage=48&rft.epage=63&rft.pages=48-63&rft.issn=1742-7061&rft.eissn=1878-7568&rft_id=info:doi/10.1016/j.actbio.2018.07.055&rft_dat=%3Cproquest_cross%3E2083707663%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2121674213&rft_id=info:pmid/30075322&rft_els_id=S1742706118304586&rfr_iscdi=true |