Effects of environmental benzene: Micronucleus frequencies and haematological values in traffic police working in an urban area
Among the toxic chemicals present in the ambient air of urban centres, benzene raises particular concern due to its haematoxicity and leukaemogenic hazards, probably related to clastogenic factors. However, little is known about the health risks associated with environmental – rather than industrial...
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description | Among the toxic chemicals present in the ambient air of urban centres, benzene raises particular concern due to its haematoxicity and leukaemogenic hazards, probably related to clastogenic factors. However, little is known about the health risks associated with environmental – rather than industrial – exposure to benzene. We analysed micronucleus (MN) frequencies in peripheral lymphocytes by use of the cytokinesis-block technique, and haematological parameters among 49 traffic police and 36 indoor workers (controls) in the city of Bologna. The analysis of urban air provided by a municipal air-quality monitoring station indicated that the levels of environmental benzene were often above the recommended threshold level (10
μg/m
3) whereas other pollutants – nitrogen oxides, polycyclic aromatic hydrocarbon compounds, total suspended particulate matter, carbon monoxide, sulfur dioxide – did not exceed the maximum atmospheric concentration established for air-quality standards. Mean levels of individual airborne benzene exposure – as measured by personal devices worn during 4-h morning work-shifts – were six-fold higher in the traffic police than in controls (
P
=
0.001). While no significant difference in haematological parameters was found between the two groups, MN frequency was significantly higher among the traffic police than in indoor workers (
P
=
0.001). Among the study population, MN frequency was found to increase with age, but no influence was observed for gender or smoking. Although it cannot be excluded that the increase of MN frequency observed in traffic police could also depend, apart from benzene, on the complex mixture of pollutants encountered in urban air, our data indicate that elevated personal benzene exposure could represent a genetic risk. The analysis of biomarkers of genetic damage in subjects particularly exposed to environmental benzene deserves careful study. |
doi_str_mv | 10.1016/j.mrgentox.2005.01.011 |
format | Article |
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μg/m
3) whereas other pollutants – nitrogen oxides, polycyclic aromatic hydrocarbon compounds, total suspended particulate matter, carbon monoxide, sulfur dioxide – did not exceed the maximum atmospheric concentration established for air-quality standards. Mean levels of individual airborne benzene exposure – as measured by personal devices worn during 4-h morning work-shifts – were six-fold higher in the traffic police than in controls (
P
=
0.001). While no significant difference in haematological parameters was found between the two groups, MN frequency was significantly higher among the traffic police than in indoor workers (
P
=
0.001). Among the study population, MN frequency was found to increase with age, but no influence was observed for gender or smoking. Although it cannot be excluded that the increase of MN frequency observed in traffic police could also depend, apart from benzene, on the complex mixture of pollutants encountered in urban air, our data indicate that elevated personal benzene exposure could represent a genetic risk. The analysis of biomarkers of genetic damage in subjects particularly exposed to environmental benzene deserves careful study.</description><identifier>ISSN: 1383-5718</identifier><identifier>ISSN: 0027-5107</identifier><identifier>EISSN: 1879-3592</identifier><identifier>DOI: 10.1016/j.mrgentox.2005.01.011</identifier><identifier>PMID: 15866461</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adult ; Air Pollutants - toxicity ; Air pollution ; Benzene - toxicity ; Benzene exposure ; Biological and medical sciences ; Biomarkers ; Case-Control Studies ; Chromosomal damage ; DNA Damage ; Female ; Fundamental and applied biological sciences. Psychology ; Genetics of eukaryotes. Biological and molecular evolution ; Hematologic Tests ; Humans ; Italy ; Lymphocytes ; Male ; Medical sciences ; Micronucleus Tests ; Molecular Epidemiology ; Mutagenic and carcinogenic risk ; Occupational Exposure ; Police ; Risk Assessment ; Toxicology ; Transportation ; Urban Population ; Vehicle Emissions</subject><ispartof>Mutation research, 2005-05, Vol.583 (1), p.1-11</ispartof><rights>2005 Elsevier B.V.</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-404ce314cac1c3451aaa48592e1a45d4d7ab0bca0236a700bd77a23bf376bfcb3</citedby><cites>FETCH-LOGICAL-c427t-404ce314cac1c3451aaa48592e1a45d4d7ab0bca0236a700bd77a23bf376bfcb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.mrgentox.2005.01.011$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16772775$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15866461$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maffei, Francesca</creatorcontrib><creatorcontrib>Hrelia, Patrizia</creatorcontrib><creatorcontrib>Angelini, Sabrina</creatorcontrib><creatorcontrib>Carbone, Fabio</creatorcontrib><creatorcontrib>Forti, Giorgio Cantelli</creatorcontrib><creatorcontrib>Barbieri, Anna</creatorcontrib><creatorcontrib>Sanguinetti, Giovanni</creatorcontrib><creatorcontrib>Mattioli, Stefano</creatorcontrib><creatorcontrib>Violante, Francesco Saverio</creatorcontrib><title>Effects of environmental benzene: Micronucleus frequencies and haematological values in traffic police working in an urban area</title><title>Mutation research</title><addtitle>Mutat Res</addtitle><description>Among the toxic chemicals present in the ambient air of urban centres, benzene raises particular concern due to its haematoxicity and leukaemogenic hazards, probably related to clastogenic factors. However, little is known about the health risks associated with environmental – rather than industrial – exposure to benzene. We analysed micronucleus (MN) frequencies in peripheral lymphocytes by use of the cytokinesis-block technique, and haematological parameters among 49 traffic police and 36 indoor workers (controls) in the city of Bologna. The analysis of urban air provided by a municipal air-quality monitoring station indicated that the levels of environmental benzene were often above the recommended threshold level (10
μg/m
3) whereas other pollutants – nitrogen oxides, polycyclic aromatic hydrocarbon compounds, total suspended particulate matter, carbon monoxide, sulfur dioxide – did not exceed the maximum atmospheric concentration established for air-quality standards. Mean levels of individual airborne benzene exposure – as measured by personal devices worn during 4-h morning work-shifts – were six-fold higher in the traffic police than in controls (
P
=
0.001). While no significant difference in haematological parameters was found between the two groups, MN frequency was significantly higher among the traffic police than in indoor workers (
P
=
0.001). Among the study population, MN frequency was found to increase with age, but no influence was observed for gender or smoking. Although it cannot be excluded that the increase of MN frequency observed in traffic police could also depend, apart from benzene, on the complex mixture of pollutants encountered in urban air, our data indicate that elevated personal benzene exposure could represent a genetic risk. The analysis of biomarkers of genetic damage in subjects particularly exposed to environmental benzene deserves careful study.</description><subject>Adult</subject><subject>Air Pollutants - toxicity</subject><subject>Air pollution</subject><subject>Benzene - toxicity</subject><subject>Benzene exposure</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Case-Control Studies</subject><subject>Chromosomal damage</subject><subject>DNA Damage</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Hematologic Tests</subject><subject>Humans</subject><subject>Italy</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Micronucleus Tests</subject><subject>Molecular Epidemiology</subject><subject>Mutagenic and carcinogenic risk</subject><subject>Occupational Exposure</subject><subject>Police</subject><subject>Risk Assessment</subject><subject>Toxicology</subject><subject>Transportation</subject><subject>Urban Population</subject><subject>Vehicle Emissions</subject><issn>1383-5718</issn><issn>0027-5107</issn><issn>1879-3592</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQQCNERUvhL1S-wC2LHSd2lhOoKh9SERc4W2NnvHhJ7MVOFsqlf51Z7aIeK1m25Xkz9jxX1ZXgK8GFerNdTXmDcU5_Vg3n3YoLGuJJdSF6va5lt26e0l72su606M-r56VsOW-45P2z6lx0vVKtEhfV_Y336ObCkmcY9yGnOFFZGJnF-BcjvmVfgqPTxY24FOYz_lowuoCFQRzYD8AJ5jSmTXCUtIdxoUiIbM7gfXBsl8bgkP1O-WeIm0MEIluypRkywovqzMNY8OVpvay-f7j5dv2pvv368fP1-9vatY2e65a3DqVoHTjhZNsJAGh76hIFtN3QDhostw54IxVozu2gNTTSeqmV9c7Ky-r1se4uJ2qgzGYKxeE4QsS0FNPwXnIl1wSqI0hNl5LRm10OE-Q7I7g5qDdb81-9Oag3XNAQlHh1umGxEw4PaSfXBLw6AVDIlc9AGssDp7RutO6Ie3fkkHzsA2ZTSHd0OIRMX2WGFB57yz_K36jv</recordid><startdate>20050502</startdate><enddate>20050502</enddate><creator>Maffei, Francesca</creator><creator>Hrelia, Patrizia</creator><creator>Angelini, Sabrina</creator><creator>Carbone, Fabio</creator><creator>Forti, Giorgio Cantelli</creator><creator>Barbieri, Anna</creator><creator>Sanguinetti, Giovanni</creator><creator>Mattioli, Stefano</creator><creator>Violante, Francesco Saverio</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7TV</scope><scope>7U2</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20050502</creationdate><title>Effects of environmental benzene: Micronucleus frequencies and haematological values in traffic police working in an urban area</title><author>Maffei, Francesca ; Hrelia, Patrizia ; Angelini, Sabrina ; Carbone, Fabio ; Forti, Giorgio Cantelli ; Barbieri, Anna ; Sanguinetti, Giovanni ; Mattioli, Stefano ; Violante, Francesco Saverio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-404ce314cac1c3451aaa48592e1a45d4d7ab0bca0236a700bd77a23bf376bfcb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Air Pollutants - toxicity</topic><topic>Air pollution</topic><topic>Benzene - toxicity</topic><topic>Benzene exposure</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Case-Control Studies</topic><topic>Chromosomal damage</topic><topic>DNA Damage</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Hematologic Tests</topic><topic>Humans</topic><topic>Italy</topic><topic>Lymphocytes</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Micronucleus Tests</topic><topic>Molecular Epidemiology</topic><topic>Mutagenic and carcinogenic risk</topic><topic>Occupational Exposure</topic><topic>Police</topic><topic>Risk Assessment</topic><topic>Toxicology</topic><topic>Transportation</topic><topic>Urban Population</topic><topic>Vehicle Emissions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maffei, Francesca</creatorcontrib><creatorcontrib>Hrelia, Patrizia</creatorcontrib><creatorcontrib>Angelini, Sabrina</creatorcontrib><creatorcontrib>Carbone, Fabio</creatorcontrib><creatorcontrib>Forti, Giorgio Cantelli</creatorcontrib><creatorcontrib>Barbieri, Anna</creatorcontrib><creatorcontrib>Sanguinetti, Giovanni</creatorcontrib><creatorcontrib>Mattioli, Stefano</creatorcontrib><creatorcontrib>Violante, Francesco Saverio</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Pollution Abstracts</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Mutation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maffei, Francesca</au><au>Hrelia, Patrizia</au><au>Angelini, Sabrina</au><au>Carbone, Fabio</au><au>Forti, Giorgio Cantelli</au><au>Barbieri, Anna</au><au>Sanguinetti, Giovanni</au><au>Mattioli, Stefano</au><au>Violante, Francesco Saverio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of environmental benzene: Micronucleus frequencies and haematological values in traffic police working in an urban area</atitle><jtitle>Mutation research</jtitle><addtitle>Mutat Res</addtitle><date>2005-05-02</date><risdate>2005</risdate><volume>583</volume><issue>1</issue><spage>1</spage><epage>11</epage><pages>1-11</pages><issn>1383-5718</issn><issn>0027-5107</issn><eissn>1879-3592</eissn><abstract>Among the toxic chemicals present in the ambient air of urban centres, benzene raises particular concern due to its haematoxicity and leukaemogenic hazards, probably related to clastogenic factors. However, little is known about the health risks associated with environmental – rather than industrial – exposure to benzene. We analysed micronucleus (MN) frequencies in peripheral lymphocytes by use of the cytokinesis-block technique, and haematological parameters among 49 traffic police and 36 indoor workers (controls) in the city of Bologna. The analysis of urban air provided by a municipal air-quality monitoring station indicated that the levels of environmental benzene were often above the recommended threshold level (10
μg/m
3) whereas other pollutants – nitrogen oxides, polycyclic aromatic hydrocarbon compounds, total suspended particulate matter, carbon monoxide, sulfur dioxide – did not exceed the maximum atmospheric concentration established for air-quality standards. Mean levels of individual airborne benzene exposure – as measured by personal devices worn during 4-h morning work-shifts – were six-fold higher in the traffic police than in controls (
P
=
0.001). While no significant difference in haematological parameters was found between the two groups, MN frequency was significantly higher among the traffic police than in indoor workers (
P
=
0.001). Among the study population, MN frequency was found to increase with age, but no influence was observed for gender or smoking. Although it cannot be excluded that the increase of MN frequency observed in traffic police could also depend, apart from benzene, on the complex mixture of pollutants encountered in urban air, our data indicate that elevated personal benzene exposure could represent a genetic risk. The analysis of biomarkers of genetic damage in subjects particularly exposed to environmental benzene deserves careful study.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>15866461</pmid><doi>10.1016/j.mrgentox.2005.01.011</doi><tpages>11</tpages></addata></record> |
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subjects | Adult Air Pollutants - toxicity Air pollution Benzene - toxicity Benzene exposure Biological and medical sciences Biomarkers Case-Control Studies Chromosomal damage DNA Damage Female Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Hematologic Tests Humans Italy Lymphocytes Male Medical sciences Micronucleus Tests Molecular Epidemiology Mutagenic and carcinogenic risk Occupational Exposure Police Risk Assessment Toxicology Transportation Urban Population Vehicle Emissions |
title | Effects of environmental benzene: Micronucleus frequencies and haematological values in traffic police working in an urban area |
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