VEGF enhance cortical newborn neurons and their neurite development in adult rat brain after cerebral ischemia

To study the effect of VEGF overexpression on development of cortical newborn neurons in the brains after stroke, we injected human VEGF 165-expressive plasmids (phVEGF) into the lateral ventricle of rat brains with a transient middle cerebral artery occlusion (MCAO). An injection of phVEGF signific...

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Veröffentlicht in:	Neurochemistry international 2009-12, Vol.55 (7), p.629-636
Hauptverfasser:	Wang, Yong-Quan, Cui, Hui-Ru, Yang, Shan-Zheng, Sun, Hua-Ping, Qiu, Mei-Hong, Feng, Xiao-Yuan, Sun, Feng-Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult brain injury Animals Animals, Newborn Antimetabolites Blotting, Western Brain Ischemia - pathology Bromodeoxyuridine Cell Line Cerebral Cortex - cytology Cerebral Cortex - drug effects Cerebral Cortex - growth & development Cerebral vascular disease DNA, Complementary - biosynthesis DNA, Complementary - genetics Fluorescent Antibody Technique Humans Immunohistochemistry Infarction, Middle Cerebral Artery - pathology Magnetic Resonance Imaging Male Microscopy, Confocal Neurites - drug effects Neurites - ultrastructure Neurons - drug effects Neurons - ultrastructure Neuroplasticity Plasmids - genetics Rats Rats, Sprague-Dawley Regeneration Stroke Transfection Vascular Endothelial Growth Factor A - pharmacology
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