Synthesis, Antiviral and Cytostatic Evaluation of Unsaturated Exomethylene and Keto D-Lyxopyranonucleoside Analogues

This report describes the synthesis of unsaturated exomethylene lyxopyranonucleoside analogues as potential biologically active agents. Commercially available 1,2,3,4‐tetra‐O‐acetyl‐α‐D‐lyxopyranose 1 was condensed with silylated thymine and uracil, respectively, deacetylated and acetalated to affor...

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Veröffentlicht in:	Archiv der Pharmazie (Weinheim) 2009-06, Vol.342 (6), p.353-360
Hauptverfasser:	Tzioumaki, Niki, Tsoukala, Evangelia, Manta, Stella, Agelis, George, Balzarini, Jan, Komiotis, Dimitri
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antiviral Agents - chemical synthesis Antiviral Agents - chemistry Antiviral Agents - pharmacology Caco-2 Cells Cell Line Cell Line, Tumor Cytotoxicity Drug Screening Assays, Antitumor Exomethylene nucleosides Humans Inhibitory Concentration 50 Ketonucleosides Mice Nucleosides - chemical synthesis Nucleosides - chemistry Nucleosides - pharmacology Unsaturated nucleosides
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