Toluene diisocyanate enhances human bronchial epithelial cells' permeability partly through the vascular endothelial growth factor pathway

Summary Background Toluene diisocyanate (TDI) is a recognized chemical asthmogen; yet, the mechanisms of its toxicity have not been elucidated. Objective To investigate the influence of TDI on the permeability of human bronchial epithelial cell (HBE; HBE135‐E6E7) monolayers in vitro, and the express...

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Veröffentlicht in:	Clinical and experimental allergy 2009-10, Vol.39 (10), p.1532-1539
Hauptverfasser:	Zhao, H., Peng, H., Cai, S-X, Li, W., Zou, F., Tong, W.
Format:	Artikel
Sprache:	eng
Schlagworte:	4-diisocyanate (TDI) Antibodies, Monoclonal - pharmacology asthma Asthma - chemically induced Asthma - metabolism Biological and medical sciences Bronchi - metabolism Bronchi - pathology Cell Line Cell Membrane - metabolism Cell Membrane - ultrastructure cell permeability Chronic obstructive pulmonary disease, asthma Epithelial Cells - metabolism Epithelial Cells - ultrastructure Fundamental and applied biological sciences. Psychology Fundamental immunology human bronchial epithelial (HBE) cells Humans Medical sciences Permeability - drug effects Pneumology Respiratory Mucosa - metabolism Respiratory Mucosa - ultrastructure Serum Albumin - chemistry Serum Albumin - metabolism Serum Albumin - pharmacology Toluene 2,4-Diisocyanate - chemistry Toluene 2,4-Diisocyanate - pharmacology Toluene 2,4-Diisocyanate - toxicity toluene-2 toluene‐2,4‐diisocyanate (TDI) vascular endothelial growth factor (VEGF) Vascular Endothelial Growth Factor A - antagonists & inhibitors Vascular Endothelial Growth Factor A - metabolism
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