Amelioration of cisplatin-induced nephrotoxicity in rats by tetramethylpyrazine, a major constituent of the Chinese herb Ligusticum wallichi

Nephrotoxicity of the anticancer drug, cisplatin (CP) involves enhanced renal generation of reactive oxygen metabolites and lipid peroxidation caused by decreased levels of antioxidants and antioxidant enzymes. Tetramethylpyrazine (TMP) is known to act as a strong antioxidant. Therefore, in the pres...

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Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 2008-07, Vol.233 (7), p.891-896
Hauptverfasser:	Ali, B.H, Al-Moundhri, M, Tag Eldin, M, Nemmar, A, Al-Siyabi, S, Annamalai, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - adverse effects antioxidant activity chemical constituents of plants cisplatin Cisplatin - adverse effects creatinine Creatinine - blood Dose-Response Relationship, Drug Drugs, Chinese Herbal - pharmacology Drugs, Chinese Herbal - therapeutic use glutathione Glutathione - metabolism Kidney - drug effects Kidney - metabolism Kidney - pathology kidneys Ligusticum Ligusticum wallichi Lipid Peroxidation - drug effects Male Necrosis - chemically induced Necrosis - pathology Necrosis - prevention & control nephrotoxicity phytochemicals pyrazines Pyrazines - pharmacology Pyrazines - therapeutic use Rats Rats, Wistar Superoxide Dismutase - metabolism tetramethylpyrazine urea Urea - blood
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