It is not "either/or": activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood

Nicotine can both activate and desensitize/inactivate nicotinic acetylcholine receptors (nAChRs). An ongoing controversy in the field is to what extent the behavioral effects of nicotine result from activation of nAChRs, and to what extent receptor desensitization is involved in these behavioral pro...

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Veröffentlicht in:	Progress in neurobiology 2008-04, Vol.84 (4), p.329-342
Hauptverfasser:	Picciotto, Marina R, Addy, Nii A, Mineur, Yann S, Brunzell, Darlene H
Format:	Artikel
Sprache:	eng
Schlagworte:	Affect - physiology Animals Down-Regulation Humans Nicotine - pharmacology Nicotinic Agonists - pharmacology Receptors, Nicotinic - drug effects Receptors, Nicotinic - physiology Reward Signal Transduction - drug effects Tobacco Use Disorder - metabolism Up-Regulation
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