Licochalcone D directly targets JAK2 to induced apoptosis in human oral squamous cell carcinoma

Licochalcone (LC) families have been reported to have a wide range of biological function such as antioxidant, antibacterial, antiviral, and anticancer effects. Although various beneficial effects of LCD were revealed, its anticancer effect in human oral squamous cancer has not been identified. To e...

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Veröffentlicht in:	Journal of cellular physiology 2019-02, Vol.234 (2), p.1780-1793
Hauptverfasser:	Seo, Ji‐Hye, Choi, Hyun Woo, Oh, Ha‐Na, Lee, Mee‐Hyun, Kim, Eunae, Yoon, Goo, Cho, Seung‐Sik, Park, Seon‐Min, Cho, Young Sik, Chae, Jung‐Il, Shim, Jung‐Hyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticancer properties Antineoplastic Agents, Phytogenic - pharmacology Antioxidants Apoptosis Apoptosis - drug effects Cancer Caspase Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Cell survival Chalcones - pharmacology Data processing Humans JAK2 Janus kinase Janus kinase 2 Janus Kinase 2 - antagonists & inhibitors Janus Kinase 2 - metabolism Janus Kinase Inhibitors - pharmacology Kinases licochalcone (LC) D Male Membrane potential Mice, Inbred BALB C Mice, Nude Mitochondria Mitochondria - drug effects Mitochondria - metabolism Mitochondria - pathology mitochondrial membrane potential (MMP) Molecular Targeted Therapy Mouth Neoplasms - drug therapy Mouth Neoplasms - enzymology Mouth Neoplasms - pathology Oral cancer Oral squamous cell carcinoma oral squamous cell carcinoma (OSCC) Proteins Reactive oxygen species reactive oxygen species (ROS) Signal Transduction Signaling Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck - drug therapy Squamous Cell Carcinoma of Head and Neck - enzymology Squamous Cell Carcinoma of Head and Neck - pathology STAT3 Stat3 protein Transcription Tumor Burden - drug effects Xenograft Model Antitumor Assays Xenografts Xenotransplantation
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