A single-cell atlas of the airway epithelium reveals the CFTR-rich pulmonary ionocyte

The functions of epithelial tissues are dictated by the types, abundance and distribution of the differentiated cells they contain. Attempts to restore tissue function after damage require knowledge of how physiological tasks are distributed among cell types, and how cell states vary between homeost...

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Veröffentlicht in:	Nature (London) 2018-08, Vol.560 (7718), p.377-381
Hauptverfasser:	Plasschaert, Lindsey W., Žilionis, Rapolas, Choo-Wing, Rayman, Savova, Virginia, Knehr, Judith, Roma, Guglielmo, Klein, Allon M., Jaffe, Aron B.
Format:	Artikel
Sprache:	eng
Schlagworte:	14/19 14/32 14/63 42 45/91 631/136/142 631/80 64 64/60 Adenosine triphosphatase Analysis Antigens ATPases Cell regulation Criminal investigation Cystic fibrosis Electrophysiology Epithelial cells Epithelium Fibrosis Fluorescent antibody technique Gene expression Genes Genetic aspects H+-transporting ATPase Heterogeneity Homeostasis Human performance Humanities and Social Sciences Immunofluorescence Kinases Letter Lung multidisciplinary Physiological aspects Population Recovery of function Regeneration Repair Respiratory tract Respiratory tract diseases RNA RNA sequencing Science Science (multidisciplinary) Signal transduction Signaling Transcription factors
Online-Zugang:	Volltext
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