Single Amino Acid Mutation in Dengue Virus NS4B Protein Has Opposing Effects on Viral Proliferation in Mammalian and Mosquito Cells

Dengue virus (DENV) has a considerable impact on the global health and is known to cause morbidity and mortality every year. By passaging DENV2 in baby hamster kidney (BHK)-21 cells, we isolated a mutant clone of DENV2 that shows rapid cytopathic effects in BHK-21 cells as compared with that showed...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Japanese Journal of Infectious Diseases 2018/11/30, Vol.71(6), pp.448-454
Hauptverfasser:	Fujiki, Jumpei, Nobori, Haruaki, Sato, Akihiko, Sasaki, Michihito, Carr, Michael, Hall, William Walmsley, Orba, Yasuko, Sawa, Hirofumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Amino Acid Substitution Amino acids Animals Aquatic insects Biotechnology C6/36 Cell Line Cell lines Cell proliferation Cloning Cricetinae Culicidae Dengue fever Dengue virus Dengue Virus - genetics Dengue Virus - physiology Gene sequencing Genetic modification Genomes Global health Mammals Membrane Proteins - genetics Morbidity Mosquitoes Mutation Mutation, Missense NS4B NS4B protein Plaques Progeny Reverse Genetics Serial Passage Strain analysis Vector-borne diseases Viral diseases Viral Nonstructural Proteins - genetics Viral Plaque Assay Virus Replication Viruses Whole Genome Sequencing
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!