Subchronic feeding study of herbicide–tolerant soybean DP-356Ø43-5 in Sprague–Dawley rats
Optimum™GAT™ 1Optimum™GAT™ is a registered trademark of Pioneer Hi-Bred International, Inc.1 soybean is a genetically modified (GM) soybean containing event DP-356Ø43-5 (356043) that was produced by integration of the coding sequences of the GAT4601 and GM–HRA proteins. In planta expression of these...
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| Veröffentlicht in: | Food and chemical toxicology 2008-06, Vol.46 (6), p.2201-2213 |
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| creator | Appenzeller, Laura M. Munley, Susan M. Hoban, Denise Sykes, Greg P. Malley, Linda A. Delaney, Bryan |
| description | Optimum™GAT™ 1Optimum™GAT™ is a registered trademark of Pioneer Hi-Bred International, Inc.1 soybean is a genetically modified (GM) soybean containing event DP-356Ø43-5 (356043) that was produced by integration of the coding sequences of the GAT4601 and GM–HRA proteins. In planta expression of these proteins confers tolerance to glyphosate and sulfonylurea/imidazolinone herbicides, respectively. This paper reports the results from a subchronic rat feeding study conducted with 356043 soybeans. Dehulled/defatted toasted meal and toasted ground hulls were prepared from soybeans from untreated plants (356043), herbicide-treated plants (356043+Gly/SU), non-transgenic isoline control (091), and three commercial non-transgenic reference varieties (93B86, 93B15, and 93M40). Individual diets conforming to standard certified rodent chow formulation (Purina Rodent LabDiet® 5002) were prepared with 20% meal (w/w) and 1.5% hulls (w/w). Diets were fed to young adult Sprague–Dawley rats (12/sex/group) for at least 93 days. Compared with rats fed the isoline control or conventional reference diets, no biologically-relevant, adverse effects were observed in rats fed diets containing 356043 or 356043+Gly/SU soybean with respect to body weight/gain, food consumption/efficiency, clinical signs, mortality, ophthalmology, neurobehavioral assessments (sensory response, grip strength, motor activity), clinical pathology (hematology, coagulation, serum chemistry, urinalysis), organ weights, and gross and microscopic pathology. The results from this study indicate that 356043 soybeans are as safe and nutritious as conventional non-GM soybeans. |
| doi_str_mv | 10.1016/j.fct.2008.02.017 |
| format | Article |
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In planta expression of these proteins confers tolerance to glyphosate and sulfonylurea/imidazolinone herbicides, respectively. This paper reports the results from a subchronic rat feeding study conducted with 356043 soybeans. Dehulled/defatted toasted meal and toasted ground hulls were prepared from soybeans from untreated plants (356043), herbicide-treated plants (356043+Gly/SU), non-transgenic isoline control (091), and three commercial non-transgenic reference varieties (93B86, 93B15, and 93M40). Individual diets conforming to standard certified rodent chow formulation (Purina Rodent LabDiet® 5002) were prepared with 20% meal (w/w) and 1.5% hulls (w/w). Diets were fed to young adult Sprague–Dawley rats (12/sex/group) for at least 93 days. Compared with rats fed the isoline control or conventional reference diets, no biologically-relevant, adverse effects were observed in rats fed diets containing 356043 or 356043+Gly/SU soybean with respect to body weight/gain, food consumption/efficiency, clinical signs, mortality, ophthalmology, neurobehavioral assessments (sensory response, grip strength, motor activity), clinical pathology (hematology, coagulation, serum chemistry, urinalysis), organ weights, and gross and microscopic pathology. The results from this study indicate that 356043 soybeans are as safe and nutritious as conventional non-GM soybeans.</description><identifier>ISSN: 0278-6915</identifier><identifier>EISSN: 1873-6351</identifier><identifier>DOI: 10.1016/j.fct.2008.02.017</identifier><identifier>PMID: 18403083</identifier><identifier>CODEN: FCTOD7</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>adverse effects ; animal behavior ; animal models ; Animals ; Behavior, Animal - drug effects ; Biological and medical sciences ; Biotechnology ; Blood Cell Count ; Blood Chemical Analysis ; Blood Coagulation - drug effects ; body weight ; Body Weight - drug effects ; Diet ; dosage ; Eating - drug effects ; Eye Diseases - chemically induced ; Eye Diseases - pathology ; Female ; field crops ; food intake ; gene expression ; Genetically modified ; Glycine max ; Glycine max - genetics ; Glycine max - toxicity ; Glyphosate acetyltransferase ; herbicide resistance ; Herbicides - toxicity ; Male ; Medical sciences ; mortality ; Motor Activity - drug effects ; Organ Size - drug effects ; pathophysiology ; Pesticides, fertilizers and other agrochemicals toxicology ; Plants, Genetically Modified - genetics ; Plants, Genetically Modified - toxicity ; Psychomotor Performance - drug effects ; Rat ; Rats ; Rats, Sprague-Dawley ; recombinant proteins ; signs and symptoms (animals and humans) ; Soybean ; soybean hulls ; soybean meal ; soybeans ; Subchronic ; subchronic toxicity ; Toxicology ; transgenic plants ; Urinalysis</subject><ispartof>Food and chemical toxicology, 2008-06, Vol.46 (6), p.2201-2213</ispartof><rights>2008 Elsevier Ltd</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c502t-a0c53faa9d6fc21aac8af0f5f58a0b456a2c1e5e0e96d1193e871c5c783dac503</citedby><cites>FETCH-LOGICAL-c502t-a0c53faa9d6fc21aac8af0f5f58a0b456a2c1e5e0e96d1193e871c5c783dac503</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0278691508000987$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20357978$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18403083$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Appenzeller, Laura M.</creatorcontrib><creatorcontrib>Munley, Susan M.</creatorcontrib><creatorcontrib>Hoban, Denise</creatorcontrib><creatorcontrib>Sykes, Greg P.</creatorcontrib><creatorcontrib>Malley, Linda A.</creatorcontrib><creatorcontrib>Delaney, Bryan</creatorcontrib><title>Subchronic feeding study of herbicide–tolerant soybean DP-356Ø43-5 in Sprague–Dawley rats</title><title>Food and chemical toxicology</title><addtitle>Food Chem Toxicol</addtitle><description>Optimum™GAT™ 1Optimum™GAT™ is a registered trademark of Pioneer Hi-Bred International, Inc.1 soybean is a genetically modified (GM) soybean containing event DP-356Ø43-5 (356043) that was produced by integration of the coding sequences of the GAT4601 and GM–HRA proteins. In planta expression of these proteins confers tolerance to glyphosate and sulfonylurea/imidazolinone herbicides, respectively. This paper reports the results from a subchronic rat feeding study conducted with 356043 soybeans. Dehulled/defatted toasted meal and toasted ground hulls were prepared from soybeans from untreated plants (356043), herbicide-treated plants (356043+Gly/SU), non-transgenic isoline control (091), and three commercial non-transgenic reference varieties (93B86, 93B15, and 93M40). Individual diets conforming to standard certified rodent chow formulation (Purina Rodent LabDiet® 5002) were prepared with 20% meal (w/w) and 1.5% hulls (w/w). Diets were fed to young adult Sprague–Dawley rats (12/sex/group) for at least 93 days. Compared with rats fed the isoline control or conventional reference diets, no biologically-relevant, adverse effects were observed in rats fed diets containing 356043 or 356043+Gly/SU soybean with respect to body weight/gain, food consumption/efficiency, clinical signs, mortality, ophthalmology, neurobehavioral assessments (sensory response, grip strength, motor activity), clinical pathology (hematology, coagulation, serum chemistry, urinalysis), organ weights, and gross and microscopic pathology. The results from this study indicate that 356043 soybeans are as safe and nutritious as conventional non-GM soybeans.</description><subject>adverse effects</subject><subject>animal behavior</subject><subject>animal models</subject><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>Blood Cell Count</subject><subject>Blood Chemical Analysis</subject><subject>Blood Coagulation - drug effects</subject><subject>body weight</subject><subject>Body Weight - drug effects</subject><subject>Diet</subject><subject>dosage</subject><subject>Eating - drug effects</subject><subject>Eye Diseases - chemically induced</subject><subject>Eye Diseases - pathology</subject><subject>Female</subject><subject>field crops</subject><subject>food intake</subject><subject>gene expression</subject><subject>Genetically modified</subject><subject>Glycine max</subject><subject>Glycine max - genetics</subject><subject>Glycine max - toxicity</subject><subject>Glyphosate acetyltransferase</subject><subject>herbicide resistance</subject><subject>Herbicides - toxicity</subject><subject>Male</subject><subject>Medical sciences</subject><subject>mortality</subject><subject>Motor Activity - drug effects</subject><subject>Organ Size - drug effects</subject><subject>pathophysiology</subject><subject>Pesticides, fertilizers and other agrochemicals toxicology</subject><subject>Plants, Genetically Modified - genetics</subject><subject>Plants, Genetically Modified - toxicity</subject><subject>Psychomotor Performance - drug effects</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>recombinant proteins</subject><subject>signs and symptoms (animals and humans)</subject><subject>Soybean</subject><subject>soybean hulls</subject><subject>soybean meal</subject><subject>soybeans</subject><subject>Subchronic</subject><subject>subchronic toxicity</subject><subject>Toxicology</subject><subject>transgenic plants</subject><subject>Urinalysis</subject><issn>0278-6915</issn><issn>1873-6351</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcGO0zAURS0EYkrhA9hANrBLeLbjxBErNAMM0kiDVGaL9eI8d1ylSbETUHf8Axv-hz_hS8ZVq2HH6m3Ovbo6j7HnHAoOvHqzKZydCgGgCxAF8PoBW3Bdy7ySij9kCxC1zquGqzP2JMYNANS8rh6zM65LkKDlgn1dza29DePgbeaIOj-sszjN3T4bXXZLofXWd_T3569p7CngMGVx3LeEQ3bxOZeq-vO7lLnK_JCtdgHX8wG9wB897bOAU3zKHjnsIz073SW7-fD-y_llfnX98dP5u6vcKhBTjmCVdIhNVzkrOKLV6MAppzRCW6oKheWkCKipOs4bSbrmVtlayw5ThVyy18feXRi_zRQns_XRUt_jQOMcjQCdNMkygfwI2jDGGMiZXfBbDHvDwRykmo1JUs1BqgFhktSUeXEqn9stdf8SJ4sJeHUCMFrsXfJkfbznBEhVN2nrkr08cg5Hg-uQmJuVAC4BGiilaBLx9khQkvXdUzDRehpsekygNKsb_X-G3gFeTZ_f</recordid><startdate>20080601</startdate><enddate>20080601</enddate><creator>Appenzeller, Laura M.</creator><creator>Munley, Susan M.</creator><creator>Hoban, Denise</creator><creator>Sykes, Greg P.</creator><creator>Malley, Linda A.</creator><creator>Delaney, Bryan</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20080601</creationdate><title>Subchronic feeding study of herbicide–tolerant soybean DP-356Ø43-5 in Sprague–Dawley rats</title><author>Appenzeller, Laura M. ; Munley, Susan M. ; Hoban, Denise ; Sykes, Greg P. ; Malley, Linda A. ; Delaney, Bryan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c502t-a0c53faa9d6fc21aac8af0f5f58a0b456a2c1e5e0e96d1193e871c5c783dac503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>adverse effects</topic><topic>animal behavior</topic><topic>animal models</topic><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>Biological and medical sciences</topic><topic>Biotechnology</topic><topic>Blood Cell Count</topic><topic>Blood Chemical Analysis</topic><topic>Blood Coagulation - drug effects</topic><topic>body weight</topic><topic>Body Weight - drug effects</topic><topic>Diet</topic><topic>dosage</topic><topic>Eating - drug effects</topic><topic>Eye Diseases - chemically induced</topic><topic>Eye Diseases - pathology</topic><topic>Female</topic><topic>field crops</topic><topic>food intake</topic><topic>gene expression</topic><topic>Genetically modified</topic><topic>Glycine max</topic><topic>Glycine max - genetics</topic><topic>Glycine max - toxicity</topic><topic>Glyphosate acetyltransferase</topic><topic>herbicide resistance</topic><topic>Herbicides - toxicity</topic><topic>Male</topic><topic>Medical sciences</topic><topic>mortality</topic><topic>Motor Activity - drug effects</topic><topic>Organ Size - drug effects</topic><topic>pathophysiology</topic><topic>Pesticides, fertilizers and other agrochemicals toxicology</topic><topic>Plants, Genetically Modified - genetics</topic><topic>Plants, Genetically Modified - toxicity</topic><topic>Psychomotor Performance - drug effects</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>recombinant proteins</topic><topic>signs and symptoms (animals and humans)</topic><topic>Soybean</topic><topic>soybean hulls</topic><topic>soybean meal</topic><topic>soybeans</topic><topic>Subchronic</topic><topic>subchronic toxicity</topic><topic>Toxicology</topic><topic>transgenic plants</topic><topic>Urinalysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Appenzeller, Laura M.</creatorcontrib><creatorcontrib>Munley, Susan M.</creatorcontrib><creatorcontrib>Hoban, Denise</creatorcontrib><creatorcontrib>Sykes, Greg P.</creatorcontrib><creatorcontrib>Malley, Linda A.</creatorcontrib><creatorcontrib>Delaney, Bryan</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Food and chemical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Appenzeller, Laura M.</au><au>Munley, Susan M.</au><au>Hoban, Denise</au><au>Sykes, Greg P.</au><au>Malley, Linda A.</au><au>Delaney, Bryan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Subchronic feeding study of herbicide–tolerant soybean DP-356Ø43-5 in Sprague–Dawley rats</atitle><jtitle>Food and chemical toxicology</jtitle><addtitle>Food Chem Toxicol</addtitle><date>2008-06-01</date><risdate>2008</risdate><volume>46</volume><issue>6</issue><spage>2201</spage><epage>2213</epage><pages>2201-2213</pages><issn>0278-6915</issn><eissn>1873-6351</eissn><coden>FCTOD7</coden><abstract>Optimum™GAT™ 1Optimum™GAT™ is a registered trademark of Pioneer Hi-Bred International, Inc.1 soybean is a genetically modified (GM) soybean containing event DP-356Ø43-5 (356043) that was produced by integration of the coding sequences of the GAT4601 and GM–HRA proteins. In planta expression of these proteins confers tolerance to glyphosate and sulfonylurea/imidazolinone herbicides, respectively. This paper reports the results from a subchronic rat feeding study conducted with 356043 soybeans. Dehulled/defatted toasted meal and toasted ground hulls were prepared from soybeans from untreated plants (356043), herbicide-treated plants (356043+Gly/SU), non-transgenic isoline control (091), and three commercial non-transgenic reference varieties (93B86, 93B15, and 93M40). Individual diets conforming to standard certified rodent chow formulation (Purina Rodent LabDiet® 5002) were prepared with 20% meal (w/w) and 1.5% hulls (w/w). Diets were fed to young adult Sprague–Dawley rats (12/sex/group) for at least 93 days. Compared with rats fed the isoline control or conventional reference diets, no biologically-relevant, adverse effects were observed in rats fed diets containing 356043 or 356043+Gly/SU soybean with respect to body weight/gain, food consumption/efficiency, clinical signs, mortality, ophthalmology, neurobehavioral assessments (sensory response, grip strength, motor activity), clinical pathology (hematology, coagulation, serum chemistry, urinalysis), organ weights, and gross and microscopic pathology. The results from this study indicate that 356043 soybeans are as safe and nutritious as conventional non-GM soybeans.</abstract><cop>Oxford</cop><cop>New York, NY</cop><pub>Elsevier Ltd</pub><pmid>18403083</pmid><doi>10.1016/j.fct.2008.02.017</doi><tpages>13</tpages></addata></record> |
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| subjects | adverse effects animal behavior animal models Animals Behavior, Animal - drug effects Biological and medical sciences Biotechnology Blood Cell Count Blood Chemical Analysis Blood Coagulation - drug effects body weight Body Weight - drug effects Diet dosage Eating - drug effects Eye Diseases - chemically induced Eye Diseases - pathology Female field crops food intake gene expression Genetically modified Glycine max Glycine max - genetics Glycine max - toxicity Glyphosate acetyltransferase herbicide resistance Herbicides - toxicity Male Medical sciences mortality Motor Activity - drug effects Organ Size - drug effects pathophysiology Pesticides, fertilizers and other agrochemicals toxicology Plants, Genetically Modified - genetics Plants, Genetically Modified - toxicity Psychomotor Performance - drug effects Rat Rats Rats, Sprague-Dawley recombinant proteins signs and symptoms (animals and humans) Soybean soybean hulls soybean meal soybeans Subchronic subchronic toxicity Toxicology transgenic plants Urinalysis |
| title | Subchronic feeding study of herbicide–tolerant soybean DP-356Ø43-5 in Sprague–Dawley rats |
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