Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody-Drug Conjugate Targeting PSMA, in Preclinical Models of Prostate Cancer

Prostate-specific membrane antigen (PSMA) is a membrane-bound glutamate carboxypeptidase that is highly expressed in nearly all prostate cancers with the highest expression in metastatic castration-resistant prostate cancer (mCRPC). The prevalence of increased surface expression and constitutive int...

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Veröffentlicht in:	Molecular cancer therapeutics 2018-10, Vol.17 (10), p.2176-2186
Hauptverfasser:	Cho, Song, Zammarchi, Francesca, Williams, David G, Havenith, Carin E G, Monks, Noel R, Tyrer, Peter, D'Hooge, Francois, Fleming, Ryan, Vashisht, Kapil, Dimasi, Nazzareno, Bertelli, Francois, Corbett, Simon, Adams, Lauren, Reinert, Halla W, Dissanayake, Sandamali, Britten, Charles E, King, Wanda, Dacosta, Karma, Tammali, Ravinder, Schifferli, Kevin, Strout, Patrick, Korade, 3rd, Martin, Masson Hinrichs, Mary Jane, Chivers, Simon, Corey, Eva, Liu, He, Kim, Sae, Bander, Neil H, Howard, Philip W, Hartley, John A, Coats, Steve, Tice, David A, Herbst, Ronald, van Berkel, Patrick H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Surface - genetics Antigens, Surface - metabolism Antineoplastic Agents, Immunological - pharmacology Biomarkers, Tumor - antagonists & inhibitors Cell Line, Tumor Cross Reactions - immunology Disease Models, Animal Drug Evaluation, Preclinical Gene Expression Glutamate Carboxypeptidase II - antagonists & inhibitors Glutamate Carboxypeptidase II - genetics Glutamate Carboxypeptidase II - metabolism Humans Immunoconjugates - pharmacology Immunohistochemistry Macaca fascicularis Male Mice Prostatic Neoplasms - drug therapy Prostatic Neoplasms - immunology Prostatic Neoplasms - pathology Xenograft Model Antitumor Assays
Online-Zugang:	Volltext
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