CDK12-mediated transcriptional regulation of noncanonical NF-κB components is essential for signaling

Members of the family of nuclear factor κB (NF-κB) transcription factors are critical for multiple cellular processes, including regulating innate and adaptive immune responses, cell proliferation, and cell survival. Canonical NF-κB complexes are retained in the cytoplasm by the inhibitory protein I...

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Veröffentlicht in:	Science signaling 2018-07, Vol.11 (541)
Hauptverfasser:	Henry, Kate L, Kellner, Debra, Bajrami, Bekim, Anderson, John E, Beyna, Mercedes, Bhisetti, Govinda, Cameron, Tom, Capacci, Andrew G, Bertolotti-Ciarlet, Andrea, Feng, Jun, Gao, Benbo, Hopkins, Brian, Jenkins, Tracy, Li, Kejie, May-Dracka, Tricia, Murugan, Paramasivam, Wei, Ru, Zeng, Weike, Allaire, Norm, Buckler, Alan, Loh, Christine, Juhasz, Peter, Lucas, Brian, Ennis, Katelin A, Vollman, Elisabeth, Cahir-McFarland, Ellen, Hett, Erik C, Ols, Michelle L
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Adaptive immunity Antineoplastic Agents - pharmacology Autoimmunity Bone Neoplasms - drug therapy Bone Neoplasms - metabolism Bone Neoplasms - pathology Cancer Cell proliferation Cell survival Cyclin-dependent kinase Cyclin-dependent kinases Cyclin-Dependent Kinases - antagonists & inhibitors Cyclin-Dependent Kinases - genetics Cyclin-Dependent Kinases - metabolism Cyclins - genetics Cyclins - metabolism Cytoplasm DNA-directed RNA polymerase Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene regulation High-Throughput Screening Assays Humans Immune response Indoles - pharmacology Inhibitors Kinases Lymphotoxin Lymphotoxin beta Receptor - antagonists & inhibitors Lymphotoxin beta Receptor - genetics Lymphotoxin beta Receptor - metabolism Mutation NF-kappa B - antagonists & inhibitors NF-kappa B - genetics NF-kappa B - metabolism NF-kappa B p52 Subunit - genetics NF-kappa B p52 Subunit - metabolism NF-kappaB-Inducing Kinase NF-κB protein Nuclear transport Osteosarcoma - drug therapy Osteosarcoma - metabolism Osteosarcoma - pathology Phosphorylation Propionates - pharmacology Protein Serine-Threonine Kinases - antagonists & inhibitors Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Proteins Proteome Ribonucleic acid RNA RNA polymerase II Signal Transduction Signaling siRNA Target recognition Therapeutic applications Transcription factors Translocation Tumor Cells, Cultured Tumor necrosis factor-TNF Tumor necrosis factor-α TWEAK Receptor - antagonists & inhibitors TWEAK Receptor - genetics TWEAK Receptor - metabolism
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