Discovery of a potent hedgehog pathway inhibitor capable of activating caspase8-dependent apoptosis

Aberrant activation of Hedgehog (Hh) signaling is associated with the development of numerous human cancers. Vismodegib is the first Hh inhibitor approved for anti-cancer therapy by targeting Smoothened (SMO), a critical regulator of the Hh pathway. However, acquisition of drug resistance to vismode...

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Veröffentlicht in:	Journal of pharmacological sciences 2018-07, Vol.137 (3), p.256-264
Hauptverfasser:	Chen, Qin, Zhang, Haoran, Wu, Meng, Wang, Qin, Luo, Lusong, Ma, Haikuo, Zhang, Xiaohu, He, Sudan
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-tumor drug Apoptosis Caspase8 Hedgehog pathway Smoothened
Online-Zugang:	Volltext
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