Systemic ethanol administration elevates deoxycorticosterone levels and chronic ethanol exposure attenuates this response

Systemic ethanol administration is known to elevate levels of the GABAergic neuroactive steroid 3α,21-dihydroxy-5α-pregnan-20-one (3α,5α-THDOC). 3α,5α-THDOC is synthesized from deoxycorticosterone (DOC) by metabolism in adrenals and brain. The present study investigated DOC levels in plasma and brai...

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Veröffentlicht in:Brain research 2005-07, Vol.1049 (1), p.104-111
Hauptverfasser: Khisti, Rahul T., Boyd, Kevin N., Kumar, Sandeep, Morrow, A. Leslie
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Sprache:eng
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