ETV6: A versatile player in leukemogenesis

Alterations of the ets family transcription factor ETV6 ( TEL) and the RUNT domain transcription factor RUNX1 ( AML1) play pivotal roles in the leukemogenesis of various types of leukemia. While only three fusion partners of RUNX1 namely ETO, ETV6 and MTG16 have been described so far, there is a ple...

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Veröffentlicht in:	Seminars in cancer biology 2005-06, Vol.15 (3), p.162-174
1. Verfasser:	Bohlander, Stefan K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology ETS Translocation Variant 6 Protein ETV6 ETV6 fusion genes Humans Leukemia - genetics Leukemia - metabolism Leukemia - pathology Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - metabolism Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - metabolism Proto-Oncogene Proteins c-ets - chemistry Proto-Oncogene Proteins c-ets - genetics Proto-Oncogene Proteins c-ets - metabolism Repressor Proteins - chemistry Repressor Proteins - genetics Repressor Proteins - metabolism Transcription Factors - genetics Transcription Factors - metabolism
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