ETV6: A versatile player in leukemogenesis
Alterations of the ets family transcription factor ETV6 ( TEL) and the RUNT domain transcription factor RUNX1 ( AML1) play pivotal roles in the leukemogenesis of various types of leukemia. While only three fusion partners of RUNX1 namely ETO, ETV6 and MTG16 have been described so far, there is a ple...
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| creator | Bohlander, Stefan K. |
| description | Alterations of the ets family transcription factor
ETV6 (
TEL) and the RUNT domain transcription factor
RUNX1 (
AML1) play pivotal roles in the leukemogenesis of various types of leukemia. While only three fusion partners of
RUNX1 namely
ETO,
ETV6 and
MTG16 have been described so far, there is a plethora of
ETV6 fusion partners with about 20 partners described so far. Apart from forming fusion genes there are other genetic alterations of
ETV6 including deletions, point mutations and possible alterations at the promoter level that might contribute to the malignant phenotype. This review will focus on
ETV6 and on the different mechanisms that are used by this gene to cause leukemia. |
| doi_str_mv | 10.1016/j.semcancer.2005.01.008 |
| format | Article |
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ETV6 (
TEL) and the RUNT domain transcription factor
RUNX1 (
AML1) play pivotal roles in the leukemogenesis of various types of leukemia. While only three fusion partners of
RUNX1 namely
ETO,
ETV6 and
MTG16 have been described so far, there is a plethora of
ETV6 fusion partners with about 20 partners described so far. Apart from forming fusion genes there are other genetic alterations of
ETV6 including deletions, point mutations and possible alterations at the promoter level that might contribute to the malignant phenotype. This review will focus on
ETV6 and on the different mechanisms that are used by this gene to cause leukemia.</description><identifier>ISSN: 1044-579X</identifier><identifier>EISSN: 1096-3650</identifier><identifier>DOI: 10.1016/j.semcancer.2005.01.008</identifier><identifier>PMID: 15826831</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Cell Transformation, Neoplastic - genetics ; Cell Transformation, Neoplastic - metabolism ; Cell Transformation, Neoplastic - pathology ; ETS Translocation Variant 6 Protein ; ETV6 ; ETV6 fusion genes ; Humans ; Leukemia - genetics ; Leukemia - metabolism ; Leukemia - pathology ; Oncogene Proteins, Fusion - genetics ; Oncogene Proteins, Fusion - metabolism ; Protein-Tyrosine Kinases - genetics ; Protein-Tyrosine Kinases - metabolism ; Proto-Oncogene Proteins c-ets - chemistry ; Proto-Oncogene Proteins c-ets - genetics ; Proto-Oncogene Proteins c-ets - metabolism ; Repressor Proteins - chemistry ; Repressor Proteins - genetics ; Repressor Proteins - metabolism ; Transcription Factors - genetics ; Transcription Factors - metabolism</subject><ispartof>Seminars in cancer biology, 2005-06, Vol.15 (3), p.162-174</ispartof><rights>2005 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-b369f7fef9bf9e5a5d413323f717742c30899ed232666a7366dfbb4c707eaf473</citedby><cites>FETCH-LOGICAL-c431t-b369f7fef9bf9e5a5d413323f717742c30899ed232666a7366dfbb4c707eaf473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.semcancer.2005.01.008$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15826831$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bohlander, Stefan K.</creatorcontrib><title>ETV6: A versatile player in leukemogenesis</title><title>Seminars in cancer biology</title><addtitle>Semin Cancer Biol</addtitle><description>Alterations of the ets family transcription factor
ETV6 (
TEL) and the RUNT domain transcription factor
RUNX1 (
AML1) play pivotal roles in the leukemogenesis of various types of leukemia. While only three fusion partners of
RUNX1 namely
ETO,
ETV6 and
MTG16 have been described so far, there is a plethora of
ETV6 fusion partners with about 20 partners described so far. Apart from forming fusion genes there are other genetic alterations of
ETV6 including deletions, point mutations and possible alterations at the promoter level that might contribute to the malignant phenotype. This review will focus on
ETV6 and on the different mechanisms that are used by this gene to cause leukemia.</description><subject>Animals</subject><subject>Cell Transformation, Neoplastic - genetics</subject><subject>Cell Transformation, Neoplastic - metabolism</subject><subject>Cell Transformation, Neoplastic - pathology</subject><subject>ETS Translocation Variant 6 Protein</subject><subject>ETV6</subject><subject>ETV6 fusion genes</subject><subject>Humans</subject><subject>Leukemia - genetics</subject><subject>Leukemia - metabolism</subject><subject>Leukemia - pathology</subject><subject>Oncogene Proteins, Fusion - genetics</subject><subject>Oncogene Proteins, Fusion - metabolism</subject><subject>Protein-Tyrosine Kinases - genetics</subject><subject>Protein-Tyrosine Kinases - metabolism</subject><subject>Proto-Oncogene Proteins c-ets - chemistry</subject><subject>Proto-Oncogene Proteins c-ets - genetics</subject><subject>Proto-Oncogene Proteins c-ets - metabolism</subject><subject>Repressor Proteins - chemistry</subject><subject>Repressor Proteins - genetics</subject><subject>Repressor Proteins - metabolism</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><issn>1044-579X</issn><issn>1096-3650</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLAzEUhYMoPqp_QWflQpjx5jHJxF0pvqDgpoq7kMncSOpMpyZtwX_vlBZdurp38Z1z4CPkikJBgcrbeZGwc3bhMBYMoCyAFgDVATmloGXOZQmH21-IvFT6_YScpTQHAC2oOCYntKyYrDg9JTf3szd5l42zDcZkV6HFbNnab4xZWGQtrj-x6z9wgSmkc3LkbZvwYn9H5PXhfjZ5yqcvj8-T8TR3gtNVXnOpvfLode01lrZsBOWcca-oUoI5DpXW2DDOpJRWcSkbX9fCKVBovVB8RK53vcvYf60xrUwXksO2tQvs18kwqKhgQ-d_IFUlL4VmA6h2oIt9ShG9WcbQ2fhtKJitTzM3vz7N1qcBagafQ_JyP7GuO2z-cnuBAzDeATgY2YQhnlzAoacJEd3KNH34d-QHVCGI5w</recordid><startdate>20050601</startdate><enddate>20050601</enddate><creator>Bohlander, Stefan K.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>H94</scope><scope>7T5</scope></search><sort><creationdate>20050601</creationdate><title>ETV6: A versatile player in leukemogenesis</title><author>Bohlander, Stefan K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-b369f7fef9bf9e5a5d413323f717742c30899ed232666a7366dfbb4c707eaf473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Cell Transformation, Neoplastic - genetics</topic><topic>Cell Transformation, Neoplastic - metabolism</topic><topic>Cell Transformation, Neoplastic - pathology</topic><topic>ETS Translocation Variant 6 Protein</topic><topic>ETV6</topic><topic>ETV6 fusion genes</topic><topic>Humans</topic><topic>Leukemia - genetics</topic><topic>Leukemia - metabolism</topic><topic>Leukemia - pathology</topic><topic>Oncogene Proteins, Fusion - genetics</topic><topic>Oncogene Proteins, Fusion - metabolism</topic><topic>Protein-Tyrosine Kinases - genetics</topic><topic>Protein-Tyrosine Kinases - metabolism</topic><topic>Proto-Oncogene Proteins c-ets - chemistry</topic><topic>Proto-Oncogene Proteins c-ets - genetics</topic><topic>Proto-Oncogene Proteins c-ets - metabolism</topic><topic>Repressor Proteins - chemistry</topic><topic>Repressor Proteins - genetics</topic><topic>Repressor Proteins - metabolism</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bohlander, Stefan K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Immunology Abstracts</collection><jtitle>Seminars in cancer biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bohlander, Stefan K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ETV6: A versatile player in leukemogenesis</atitle><jtitle>Seminars in cancer biology</jtitle><addtitle>Semin Cancer Biol</addtitle><date>2005-06-01</date><risdate>2005</risdate><volume>15</volume><issue>3</issue><spage>162</spage><epage>174</epage><pages>162-174</pages><issn>1044-579X</issn><eissn>1096-3650</eissn><abstract>Alterations of the ets family transcription factor
ETV6 (
TEL) and the RUNT domain transcription factor
RUNX1 (
AML1) play pivotal roles in the leukemogenesis of various types of leukemia. While only three fusion partners of
RUNX1 namely
ETO,
ETV6 and
MTG16 have been described so far, there is a plethora of
ETV6 fusion partners with about 20 partners described so far. Apart from forming fusion genes there are other genetic alterations of
ETV6 including deletions, point mutations and possible alterations at the promoter level that might contribute to the malignant phenotype. This review will focus on
ETV6 and on the different mechanisms that are used by this gene to cause leukemia.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>15826831</pmid><doi>10.1016/j.semcancer.2005.01.008</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Seminars in cancer biology, 2005-06, Vol.15 (3), p.162-174 |
| issn | 1044-579X 1096-3650 |
| language | eng |
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| source | MEDLINE; ScienceDirect Freedom Collection (Elsevier) |
| subjects | Animals Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology ETS Translocation Variant 6 Protein ETV6 ETV6 fusion genes Humans Leukemia - genetics Leukemia - metabolism Leukemia - pathology Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - metabolism Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - metabolism Proto-Oncogene Proteins c-ets - chemistry Proto-Oncogene Proteins c-ets - genetics Proto-Oncogene Proteins c-ets - metabolism Repressor Proteins - chemistry Repressor Proteins - genetics Repressor Proteins - metabolism Transcription Factors - genetics Transcription Factors - metabolism |
| title | ETV6: A versatile player in leukemogenesis |
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