Bioinsecticidal effect of harmaline on Plodia interpunctella development (Lepidoptera: Pyralidae)
We have investigated the effects of harmaline, a plant secondary metabolic compound belonging to β-carboline alkaloids, on the 4th instar larvae of Plodia interpunctella (Lepidoptera). When incorporated into the diet, harmaline caused weight loss of larvae with a reduction in protein and glycogen co...
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| Veröffentlicht in: | Pesticide biochemistry and physiology 2007-10, Vol.89 (2), p.137-145 |
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| container_title | Pesticide biochemistry and physiology |
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| creator | Rharrabe, Kacem Bakrim, Ahmed Ghailani, Naima Sayah, Fouad |
| description | We have investigated the effects of harmaline, a plant secondary metabolic compound belonging to β-carboline alkaloids, on the 4th instar larvae of
Plodia interpunctella (Lepidoptera). When incorporated into the diet, harmaline caused weight loss of larvae with a reduction in protein and glycogen contents and an inhibition of α-amylase activity. Using electron microscopy, we showed that harmaline provoked a severe cytotoxicity on the epithelial cells of the midgut resulting in marked vacuolization of the cytoplasm, appearance of numerous autophagic vesicles and lysosomic structures, fragmentation of rough endoplasmic reticulum cisternae, disruption of microvilli, rupture of the plasma membrane leading to shedding of the cytoplasm contents into the midgut lumen. The development of larvae to the pupal and adult stages was prevented and high mortality was recorded. |
| doi_str_mv | 10.1016/j.pestbp.2007.05.002 |
| format | Article |
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Plodia interpunctella (Lepidoptera). When incorporated into the diet, harmaline caused weight loss of larvae with a reduction in protein and glycogen contents and an inhibition of α-amylase activity. Using electron microscopy, we showed that harmaline provoked a severe cytotoxicity on the epithelial cells of the midgut resulting in marked vacuolization of the cytoplasm, appearance of numerous autophagic vesicles and lysosomic structures, fragmentation of rough endoplasmic reticulum cisternae, disruption of microvilli, rupture of the plasma membrane leading to shedding of the cytoplasm contents into the midgut lumen. The development of larvae to the pupal and adult stages was prevented and high mortality was recorded.</description><subject>Alkaloid</subject><subject>Bioinsecticide</subject><subject>Biological and medical sciences</subject><subject>Control</subject><subject>Cytotoxicity</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Harmaline</subject><subject>Insect</subject><subject>Invertebrates</subject><subject>Lepidoptera</subject><subject>Medically important nuisances and vectors, pests of stored products and materials: population survey and control</subject><subject>Midgut</subject><subject>Pests of stored products</subject><subject>Phytopathology. Animal pests. Plant and forest protection</subject><subject>Plodia interpunctella</subject><subject>Protozoa. Invertebrates</subject><subject>Pyralidae</subject><issn>0048-3575</issn><issn>1095-9939</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LJDEQhoO4sKO7_8BDLooeurfS6XRPPAgqfsHAzmE9h0xSwQw9SZv0DPjvN8MI3jyFgud9K_UQcsagZsC6P-t6xDytxroB6GsQNUBzRGYMpKik5PKYzADaecVFL36Sk5zXACBbkDOi73z0IaOZvPFWDxSdKwONjr7ptNGDD0hjoMshWq-pDxOmcRvMhMOgqcUdDnHcYJjo5QJHb-NYAH1Nlx-pZK3Gq1_kh9NDxt-f7yl5fXz4d_9cLf4-vdzfLirTcj5VXLcWO2x6QNcIjp3RgktnhGvmfY9NZ1diZRkXBqTrUSDjnZQlwGRvQXb8lFwcescU37fFh9r4bPbfDBi3WTUwZ7x0FbA9gCbFnBM6NSa_0elDMVB7n2qtDj7V3qcCoYrPEjv_7NfZ6MElHYzPX1kJHWNyz90cOCzH7jwmlY3HYND6VMwqG_33i_4DUR-OpA</recordid><startdate>20071001</startdate><enddate>20071001</enddate><creator>Rharrabe, Kacem</creator><creator>Bakrim, Ahmed</creator><creator>Ghailani, Naima</creator><creator>Sayah, Fouad</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope></search><sort><creationdate>20071001</creationdate><title>Bioinsecticidal effect of harmaline on Plodia interpunctella development (Lepidoptera: Pyralidae)</title><author>Rharrabe, Kacem ; Bakrim, Ahmed ; Ghailani, Naima ; Sayah, Fouad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c433t-3a4de6e270ef253e6ca539fc5f2877e26db5bd135c09f7e5e136996e2197d0963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Alkaloid</topic><topic>Bioinsecticide</topic><topic>Biological and medical sciences</topic><topic>Control</topic><topic>Cytotoxicity</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Harmaline</topic><topic>Insect</topic><topic>Invertebrates</topic><topic>Lepidoptera</topic><topic>Medically important nuisances and vectors, pests of stored products and materials: population survey and control</topic><topic>Midgut</topic><topic>Pests of stored products</topic><topic>Phytopathology. Animal pests. Plant and forest protection</topic><topic>Plodia interpunctella</topic><topic>Protozoa. Invertebrates</topic><topic>Pyralidae</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rharrabe, Kacem</creatorcontrib><creatorcontrib>Bakrim, Ahmed</creatorcontrib><creatorcontrib>Ghailani, Naima</creatorcontrib><creatorcontrib>Sayah, Fouad</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><jtitle>Pesticide biochemistry and physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rharrabe, Kacem</au><au>Bakrim, Ahmed</au><au>Ghailani, Naima</au><au>Sayah, Fouad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bioinsecticidal effect of harmaline on Plodia interpunctella development (Lepidoptera: Pyralidae)</atitle><jtitle>Pesticide biochemistry and physiology</jtitle><date>2007-10-01</date><risdate>2007</risdate><volume>89</volume><issue>2</issue><spage>137</spage><epage>145</epage><pages>137-145</pages><issn>0048-3575</issn><eissn>1095-9939</eissn><coden>PCBPBS</coden><abstract>We have investigated the effects of harmaline, a plant secondary metabolic compound belonging to β-carboline alkaloids, on the 4th instar larvae of
Plodia interpunctella (Lepidoptera). When incorporated into the diet, harmaline caused weight loss of larvae with a reduction in protein and glycogen contents and an inhibition of α-amylase activity. Using electron microscopy, we showed that harmaline provoked a severe cytotoxicity on the epithelial cells of the midgut resulting in marked vacuolization of the cytoplasm, appearance of numerous autophagic vesicles and lysosomic structures, fragmentation of rough endoplasmic reticulum cisternae, disruption of microvilli, rupture of the plasma membrane leading to shedding of the cytoplasm contents into the midgut lumen. The development of larvae to the pupal and adult stages was prevented and high mortality was recorded.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><doi>10.1016/j.pestbp.2007.05.002</doi><tpages>9</tpages></addata></record> |
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| ispartof | Pesticide biochemistry and physiology, 2007-10, Vol.89 (2), p.137-145 |
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| language | eng |
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| source | ScienceDirect Journals (5 years ago - present) |
| subjects | Alkaloid Bioinsecticide Biological and medical sciences Control Cytotoxicity Fundamental and applied biological sciences. Psychology Harmaline Insect Invertebrates Lepidoptera Medically important nuisances and vectors, pests of stored products and materials: population survey and control Midgut Pests of stored products Phytopathology. Animal pests. Plant and forest protection Plodia interpunctella Protozoa. Invertebrates Pyralidae |
| title | Bioinsecticidal effect of harmaline on Plodia interpunctella development (Lepidoptera: Pyralidae) |
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