Epigenetic inactivation of protein kinase D1 in gastric cancer and its role in gastric cancer cell migration and invasion

Protein kinase D (PKD) 1 influences cell migration by mediating both trans-Golgi vesicle fission and integrin recycling to the cell surface. Using restriction landmark genomic scanning methods, we found that the promoter region of PKD1 was aberrantly methylated in gastric cancer cell lines. Silencin...

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Veröffentlicht in:	Carcinogenesis (New York) 2008-03, Vol.29 (3), p.629-637
Hauptverfasser:	Kim, Mirang, Jang, Hay-Ran, Kim, Jeong-Hwan, Noh, Seung-Moo, Song, Kyu-Sang, Cho, June-Sik, Jeong, Hyun-Yong, Norman, Jim C., Caswell, Patrick T., Kang, Gyeong Hoon, Kim, Seon-Young, Yoo, Hyang-Sook, Kim, Yong Sung
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Base Sequence Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens CpG Islands DNA Methylation DNA Primers Epigenesis, Genetic Female Gastroenterology. Liver. Pancreas. Abdomen Gene Silencing Humans Male Medical sciences Middle Aged Neoplasm Invasiveness - genetics Neoplasm Metastasis - genetics Protein Kinase C - genetics Reverse Transcriptase Polymerase Chain Reaction RNA, Small Interfering Stomach Neoplasms - enzymology Stomach Neoplasms - genetics Stomach Neoplasms - pathology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors
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