The antimalarials quinacrine and chloroquine potentiate the transplacental carcinogenic effect of ethylnitrosourea on ependymal cells

Quinacrine and chloroquine, two widely used antimalarials, bind strongly to deoxyribonucleic acid, thus preventing mutagenesis. We studied a possible chemoprotective effect of these substances on carcinogenesis of the nervous system induced in Wistar rats by transplacental administration of ethylnit...

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Veröffentlicht in:	Brain tumor pathology 2001-09, Vol.18 (2), p.83-87
Hauptverfasser:	Reyes, S, Rembao, D, Sotelo, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimalarials - toxicity Antiparasitic agents Brain Neoplasms - chemically induced Carcinogens Carcinogens - toxicity Chloroquine - toxicity Drug Synergism Ependyma - cytology Ependyma - drug effects Ependymoma - chemically induced Ethylnitrosourea - toxicity Female Glial Fibrillary Acidic Protein - analysis Immunoenzyme Techniques Male Nervous system Pregnancy Prenatal exposure Prenatal Exposure Delayed Effects Quinacrine - toxicity Rats Rats, Wistar Spinal Cord Neoplasms - chemically induced Synaptophysin - analysis
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