Skeletal Muscle Volume and Intramuscular Adipose Tissue Are Prognostic Predictors of Postoperative Complications After Hepatic Resection
Recently, skeletal muscle quality was important in patients with malignant tumors to predict the surgical outcome. The relationship between postoperative complications of Clavien-Dindo grade III or more and prognosis in patients who have undergone hepatic resection for hepatic malignancies were inve...
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| Veröffentlicht in: | Anticancer research 2018-08, Vol.38 (8), p.4933-4939 |
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| creator | Harimoto, Norifumi Hoshino, Hiroki Muranushi, Ryo Hagiwara, Kei Yamanaka, Takahiro Ishii, Norihiro Tsukagoshi, Mariko Igarashi, Takamichi Watanabe, Akira Kubo, Norio Araki, Kenichirou Shirabe, Ken |
| description | Recently, skeletal muscle quality was important in patients with malignant tumors to predict the surgical outcome. The relationship between postoperative complications of Clavien-Dindo grade III or more and prognosis in patients who have undergone hepatic resection for hepatic malignancies were investigated.
Patient data were retrospectively collected for 146 consecutive patients who underwent curative hepatic resection in the Department of Hepatobiliary and Pancreatic Surgery, Gunma University, Japan, for hepatic malignancy. The patients were assigned to two groups according to the presence of postoperative complications. The clinicopathological and surgical outcomes were analyzed. Skeletal muscle area (SMA) and intramuscular adipose tissue content (IMAC) were also evaluated.
No hospital deaths occurred. Postoperative complications were identified in 12 patients (8.2%). Univariate and multivariate analyses revealed that the independent risk factors for postoperative complications were hemodialysis, psychiatric disorder, high CONUT (controlling nutritional status) score and patients both with low SMA and high IMAC.
Intensive surgical care is necessary for high-risk patients with hemodialysis, psychiatric disorder, high CONUT count and/or low skeletal muscle quality to reduce postoperative complication. |
| doi_str_mv | 10.21873/anticanres.12810 |
| format | Article |
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Patient data were retrospectively collected for 146 consecutive patients who underwent curative hepatic resection in the Department of Hepatobiliary and Pancreatic Surgery, Gunma University, Japan, for hepatic malignancy. The patients were assigned to two groups according to the presence of postoperative complications. The clinicopathological and surgical outcomes were analyzed. Skeletal muscle area (SMA) and intramuscular adipose tissue content (IMAC) were also evaluated.
No hospital deaths occurred. Postoperative complications were identified in 12 patients (8.2%). Univariate and multivariate analyses revealed that the independent risk factors for postoperative complications were hemodialysis, psychiatric disorder, high CONUT (controlling nutritional status) score and patients both with low SMA and high IMAC.
Intensive surgical care is necessary for high-risk patients with hemodialysis, psychiatric disorder, high CONUT count and/or low skeletal muscle quality to reduce postoperative complication.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>DOI: 10.21873/anticanres.12810</identifier><identifier>PMID: 30061272</identifier><language>eng</language><publisher>Greece: International Institute of Anticancer Research</publisher><subject>Adipose tissue ; Adipose Tissue - pathology ; Aged ; Behavior disorders ; Carcinoma, Hepatocellular - pathology ; Carcinoma, Hepatocellular - surgery ; Complications ; Dialysis ; Disease-Free Survival ; Female ; Hemodialysis ; Hepatectomy - adverse effects ; Humans ; Liver ; Liver - pathology ; Liver - surgery ; Liver Neoplasms - pathology ; Liver Neoplasms - surgery ; Male ; Malignancy ; Mental Disorders ; Muscle, Skeletal - pathology ; Muscles ; Musculoskeletal system ; Nutritional status ; Pancreas ; Patients ; Postoperative Complications - etiology ; Retrospective Studies ; Risk analysis ; Risk factors ; Risk groups ; Sarcopenia - pathology ; Skeletal muscle ; Surgery ; Tumors</subject><ispartof>Anticancer research, 2018-08, Vol.38 (8), p.4933-4939</ispartof><rights>Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.</rights><rights>Copyright International Institute of Anticancer Research Aug 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30061272$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Harimoto, Norifumi</creatorcontrib><creatorcontrib>Hoshino, Hiroki</creatorcontrib><creatorcontrib>Muranushi, Ryo</creatorcontrib><creatorcontrib>Hagiwara, Kei</creatorcontrib><creatorcontrib>Yamanaka, Takahiro</creatorcontrib><creatorcontrib>Ishii, Norihiro</creatorcontrib><creatorcontrib>Tsukagoshi, Mariko</creatorcontrib><creatorcontrib>Igarashi, Takamichi</creatorcontrib><creatorcontrib>Watanabe, Akira</creatorcontrib><creatorcontrib>Kubo, Norio</creatorcontrib><creatorcontrib>Araki, Kenichirou</creatorcontrib><creatorcontrib>Shirabe, Ken</creatorcontrib><title>Skeletal Muscle Volume and Intramuscular Adipose Tissue Are Prognostic Predictors of Postoperative Complications After Hepatic Resection</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>Recently, skeletal muscle quality was important in patients with malignant tumors to predict the surgical outcome. The relationship between postoperative complications of Clavien-Dindo grade III or more and prognosis in patients who have undergone hepatic resection for hepatic malignancies were investigated.
Patient data were retrospectively collected for 146 consecutive patients who underwent curative hepatic resection in the Department of Hepatobiliary and Pancreatic Surgery, Gunma University, Japan, for hepatic malignancy. The patients were assigned to two groups according to the presence of postoperative complications. The clinicopathological and surgical outcomes were analyzed. Skeletal muscle area (SMA) and intramuscular adipose tissue content (IMAC) were also evaluated.
No hospital deaths occurred. Postoperative complications were identified in 12 patients (8.2%). Univariate and multivariate analyses revealed that the independent risk factors for postoperative complications were hemodialysis, psychiatric disorder, high CONUT (controlling nutritional status) score and patients both with low SMA and high IMAC.
Intensive surgical care is necessary for high-risk patients with hemodialysis, psychiatric disorder, high CONUT count and/or low skeletal muscle quality to reduce postoperative complication.</description><subject>Adipose tissue</subject><subject>Adipose Tissue - pathology</subject><subject>Aged</subject><subject>Behavior disorders</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Carcinoma, Hepatocellular - surgery</subject><subject>Complications</subject><subject>Dialysis</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Hemodialysis</subject><subject>Hepatectomy - adverse effects</subject><subject>Humans</subject><subject>Liver</subject><subject>Liver - pathology</subject><subject>Liver - surgery</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver Neoplasms - surgery</subject><subject>Male</subject><subject>Malignancy</subject><subject>Mental Disorders</subject><subject>Muscle, Skeletal - pathology</subject><subject>Muscles</subject><subject>Musculoskeletal system</subject><subject>Nutritional status</subject><subject>Pancreas</subject><subject>Patients</subject><subject>Postoperative Complications - etiology</subject><subject>Retrospective Studies</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Risk groups</subject><subject>Sarcopenia - pathology</subject><subject>Skeletal muscle</subject><subject>Surgery</subject><subject>Tumors</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkMtKxjAQhYMo-nt5ADcScOOmOkl6SZY_P95AUbxtS5pOpZo2NUkF38DHNqJuXM3hzDfD4RCyz-CYM1mJEz3G3ujRYzhmXDJYIwtWKZZVhYB1sgBeQFYBFFtkO4QXgLJUUmySLZEk4xVfkM_7V7QYtaXXczAW6ZOz84BUjy29HKPXQ7Jnqz1dtv3kAtKHPoQZ6dIjvfXueXQhZUgS295E5wN1Hb1NppvQ69i_I125YbIpZ-zdGOiyi-jpBU76--4OA5rvxS7Z6LQNuPc7d8jj2enD6iK7ujm_XC2vsomVKmYlKmi40JUomZKgWpNzAQY067TqjGxynUvVshwLXXEObSMK05VN2-RCcjBihxz9_J28e5sxxHrog0Fr9YhuDjUHCbIooVAJPfyHvrjZjyldzZmo8gJyWSbq4JeamwHbevL9oP1H_dex-AKu2oHr</recordid><startdate>201808</startdate><enddate>201808</enddate><creator>Harimoto, Norifumi</creator><creator>Hoshino, Hiroki</creator><creator>Muranushi, Ryo</creator><creator>Hagiwara, Kei</creator><creator>Yamanaka, Takahiro</creator><creator>Ishii, Norihiro</creator><creator>Tsukagoshi, Mariko</creator><creator>Igarashi, Takamichi</creator><creator>Watanabe, Akira</creator><creator>Kubo, Norio</creator><creator>Araki, Kenichirou</creator><creator>Shirabe, Ken</creator><general>International Institute of Anticancer Research</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QO</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201808</creationdate><title>Skeletal Muscle Volume and Intramuscular Adipose Tissue Are Prognostic Predictors of Postoperative Complications After Hepatic Resection</title><author>Harimoto, Norifumi ; Hoshino, Hiroki ; Muranushi, Ryo ; Hagiwara, Kei ; Yamanaka, Takahiro ; Ishii, Norihiro ; Tsukagoshi, Mariko ; Igarashi, Takamichi ; Watanabe, Akira ; Kubo, Norio ; Araki, Kenichirou ; Shirabe, Ken</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p169t-6e90b23a73619809dc4230c0a1fa9fc8b4a489d14e5a7220db35cf6bdb43820c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adipose tissue</topic><topic>Adipose Tissue - pathology</topic><topic>Aged</topic><topic>Behavior disorders</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Carcinoma, Hepatocellular - surgery</topic><topic>Complications</topic><topic>Dialysis</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Hemodialysis</topic><topic>Hepatectomy - adverse effects</topic><topic>Humans</topic><topic>Liver</topic><topic>Liver - pathology</topic><topic>Liver - surgery</topic><topic>Liver Neoplasms - pathology</topic><topic>Liver Neoplasms - surgery</topic><topic>Male</topic><topic>Malignancy</topic><topic>Mental Disorders</topic><topic>Muscle, Skeletal - pathology</topic><topic>Muscles</topic><topic>Musculoskeletal system</topic><topic>Nutritional status</topic><topic>Pancreas</topic><topic>Patients</topic><topic>Postoperative Complications - etiology</topic><topic>Retrospective Studies</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Risk groups</topic><topic>Sarcopenia - pathology</topic><topic>Skeletal muscle</topic><topic>Surgery</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harimoto, Norifumi</creatorcontrib><creatorcontrib>Hoshino, Hiroki</creatorcontrib><creatorcontrib>Muranushi, Ryo</creatorcontrib><creatorcontrib>Hagiwara, Kei</creatorcontrib><creatorcontrib>Yamanaka, Takahiro</creatorcontrib><creatorcontrib>Ishii, Norihiro</creatorcontrib><creatorcontrib>Tsukagoshi, Mariko</creatorcontrib><creatorcontrib>Igarashi, Takamichi</creatorcontrib><creatorcontrib>Watanabe, Akira</creatorcontrib><creatorcontrib>Kubo, Norio</creatorcontrib><creatorcontrib>Araki, Kenichirou</creatorcontrib><creatorcontrib>Shirabe, Ken</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harimoto, Norifumi</au><au>Hoshino, Hiroki</au><au>Muranushi, Ryo</au><au>Hagiwara, Kei</au><au>Yamanaka, Takahiro</au><au>Ishii, Norihiro</au><au>Tsukagoshi, Mariko</au><au>Igarashi, Takamichi</au><au>Watanabe, Akira</au><au>Kubo, Norio</au><au>Araki, Kenichirou</au><au>Shirabe, Ken</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Skeletal Muscle Volume and Intramuscular Adipose Tissue Are Prognostic Predictors of Postoperative Complications After Hepatic Resection</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2018-08</date><risdate>2018</risdate><volume>38</volume><issue>8</issue><spage>4933</spage><epage>4939</epage><pages>4933-4939</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>Recently, skeletal muscle quality was important in patients with malignant tumors to predict the surgical outcome. The relationship between postoperative complications of Clavien-Dindo grade III or more and prognosis in patients who have undergone hepatic resection for hepatic malignancies were investigated.
Patient data were retrospectively collected for 146 consecutive patients who underwent curative hepatic resection in the Department of Hepatobiliary and Pancreatic Surgery, Gunma University, Japan, for hepatic malignancy. The patients were assigned to two groups according to the presence of postoperative complications. The clinicopathological and surgical outcomes were analyzed. Skeletal muscle area (SMA) and intramuscular adipose tissue content (IMAC) were also evaluated.
No hospital deaths occurred. Postoperative complications were identified in 12 patients (8.2%). Univariate and multivariate analyses revealed that the independent risk factors for postoperative complications were hemodialysis, psychiatric disorder, high CONUT (controlling nutritional status) score and patients both with low SMA and high IMAC.
Intensive surgical care is necessary for high-risk patients with hemodialysis, psychiatric disorder, high CONUT count and/or low skeletal muscle quality to reduce postoperative complication.</abstract><cop>Greece</cop><pub>International Institute of Anticancer Research</pub><pmid>30061272</pmid><doi>10.21873/anticanres.12810</doi><tpages>7</tpages></addata></record> |
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| subjects | Adipose tissue Adipose Tissue - pathology Aged Behavior disorders Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - surgery Complications Dialysis Disease-Free Survival Female Hemodialysis Hepatectomy - adverse effects Humans Liver Liver - pathology Liver - surgery Liver Neoplasms - pathology Liver Neoplasms - surgery Male Malignancy Mental Disorders Muscle, Skeletal - pathology Muscles Musculoskeletal system Nutritional status Pancreas Patients Postoperative Complications - etiology Retrospective Studies Risk analysis Risk factors Risk groups Sarcopenia - pathology Skeletal muscle Surgery Tumors |
| title | Skeletal Muscle Volume and Intramuscular Adipose Tissue Are Prognostic Predictors of Postoperative Complications After Hepatic Resection |
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