BMP1 5'UTR + 104 T/C gene variation: can be a predictive marker for serum HDL and apoprotein A1 levels in male patients with coronary heart disease
Apolipoprotein A1 (Apo A1), the major protein of HDL, is secreted as a proprotein and then is cleaved by C-terminal procollagen endoproteinase/bone morphogenetic protein-1 (BMP1). BMP1 stimulates the conversion of newly secreted proapo A1 to its phospholipid-binding form. Therefore, genetic variatio...
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Veröffentlicht in: | Molecular biology reports 2018-10, Vol.45 (5), p.1269-1276 |
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description | Apolipoprotein A1 (Apo A1), the major protein of HDL, is secreted as a proprotein and then is cleaved by C-terminal procollagen endoproteinase/bone morphogenetic protein-1 (BMP1). BMP1 stimulates the conversion of newly secreted proapo A1 to its phospholipid-binding form. Therefore, genetic variations of BMP1 gene may affect serum ApoA1 and HDL levels. We aimed to investigate the effects of the functional 5'UTR + 104 (T/C) variant of BMP1 on serum ApoA1 and HDL levels and risk of coronary heart disease (CHD) in this study. The BMP1 5'UTR + 104 (T/C) (rs143383) variation was determined in 131 male patients with CHD and 51 male controls by real-time polymerase chain reaction technique. ApoA1 levels were measured by immunoturbidimetry. The serum Apo-A1 levels were found higher in controls with the BMP1-CC genotype than those with the T-allele (p |
doi_str_mv | 10.1007/s11033-018-4283-8 |
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BMP1 stimulates the conversion of newly secreted proapo A1 to its phospholipid-binding form. Therefore, genetic variations of BMP1 gene may affect serum ApoA1 and HDL levels. We aimed to investigate the effects of the functional 5'UTR + 104 (T/C) variant of BMP1 on serum ApoA1 and HDL levels and risk of coronary heart disease (CHD) in this study. The BMP1 5'UTR + 104 (T/C) (rs143383) variation was determined in 131 male patients with CHD and 51 male controls by real-time polymerase chain reaction technique. ApoA1 levels were measured by immunoturbidimetry. The serum Apo-A1 levels were found higher in controls with the BMP1-CC genotype than those with the T-allele (p < 0.001). Our findings show the association of this variation with serum ApoA1 and HDL-C levels which increase in the order of CT < TT < CC in the controls. No effect was found on ApoA1 and HDL-C levels in CHD patients, as it was observed in the controls. However, the BMP1-TT genotype was associated with higher triglyceride (TG) levels as compared to C-allele (p = 0.009). These discrepancies could be due to statin therapy which has dominant effects on lowering cholesterol levels comparing to TG levels. Our results indicated that the BMP1 5'UTR + 104 (T/C) variation may affect the serum ApoA1 and lipoprotein levels depending on statin therapy so that contributes to the development of CHD.</description><identifier>EISSN: 1573-4978</identifier><identifier>DOI: 10.1007/s11033-018-4283-8</identifier><identifier>PMID: 30062502</identifier><language>eng</language><publisher>Netherlands</publisher><subject>5' Untranslated Regions - genetics ; Alleles ; Apolipoprotein A-I - analysis ; Apolipoprotein A-I - blood ; Apolipoprotein A-I - genetics ; Biomarkers - blood ; Bone Morphogenetic Protein 1 - blood ; Bone Morphogenetic Protein 1 - genetics ; Cholesterol, HDL - analysis ; Cholesterol, HDL - blood ; Coronary Disease - genetics ; Gene Frequency - genetics ; Genotype ; Humans ; Lipids - blood ; Male ; Middle Aged ; Polymorphism, Single Nucleotide - genetics ; Risk Factors</subject><ispartof>Molecular biology reports, 2018-10, Vol.45 (5), p.1269-1276</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-9904-0146 ; 0000-0002-8837-6664 ; 0000-0002-0234-7548 ; 0000-0002-4583-6890 ; 0000-0001-9827-5253 ; 0000-0003-3618-0560 ; 0000-0002-2439-9269</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30062502$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Akadam-Teker, Basak</creatorcontrib><creatorcontrib>Ozkara, Gulcin</creatorcontrib><creatorcontrib>Kurnaz-Gomleksiz, Ozlem</creatorcontrib><creatorcontrib>Bugra, Zehra</creatorcontrib><creatorcontrib>Teker, Erhan</creatorcontrib><creatorcontrib>Ozturk, Oguz</creatorcontrib><creatorcontrib>Yilmaz-Aydogan, Hulya</creatorcontrib><title>BMP1 5'UTR + 104 T/C gene variation: can be a predictive marker for serum HDL and apoprotein A1 levels in male patients with coronary heart disease</title><title>Molecular biology reports</title><addtitle>Mol Biol Rep</addtitle><description>Apolipoprotein A1 (Apo A1), the major protein of HDL, is secreted as a proprotein and then is cleaved by C-terminal procollagen endoproteinase/bone morphogenetic protein-1 (BMP1). BMP1 stimulates the conversion of newly secreted proapo A1 to its phospholipid-binding form. Therefore, genetic variations of BMP1 gene may affect serum ApoA1 and HDL levels. We aimed to investigate the effects of the functional 5'UTR + 104 (T/C) variant of BMP1 on serum ApoA1 and HDL levels and risk of coronary heart disease (CHD) in this study. The BMP1 5'UTR + 104 (T/C) (rs143383) variation was determined in 131 male patients with CHD and 51 male controls by real-time polymerase chain reaction technique. ApoA1 levels were measured by immunoturbidimetry. The serum Apo-A1 levels were found higher in controls with the BMP1-CC genotype than those with the T-allele (p < 0.001). Our findings show the association of this variation with serum ApoA1 and HDL-C levels which increase in the order of CT < TT < CC in the controls. No effect was found on ApoA1 and HDL-C levels in CHD patients, as it was observed in the controls. However, the BMP1-TT genotype was associated with higher triglyceride (TG) levels as compared to C-allele (p = 0.009). These discrepancies could be due to statin therapy which has dominant effects on lowering cholesterol levels comparing to TG levels. Our results indicated that the BMP1 5'UTR + 104 (T/C) variation may affect the serum ApoA1 and lipoprotein levels depending on statin therapy so that contributes to the development of CHD.</description><subject>5' Untranslated Regions - genetics</subject><subject>Alleles</subject><subject>Apolipoprotein A-I - analysis</subject><subject>Apolipoprotein A-I - blood</subject><subject>Apolipoprotein A-I - genetics</subject><subject>Biomarkers - blood</subject><subject>Bone Morphogenetic Protein 1 - blood</subject><subject>Bone Morphogenetic Protein 1 - genetics</subject><subject>Cholesterol, HDL - analysis</subject><subject>Cholesterol, HDL - blood</subject><subject>Coronary Disease - genetics</subject><subject>Gene Frequency - genetics</subject><subject>Genotype</subject><subject>Humans</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Risk Factors</subject><issn>1573-4978</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1UM1Kw0AYXASxWn0AL_LdFCR2t7vZJN60_lSoKNKey5fkW7uaP3fTSm9efQOPPouP4pMYUA_DMDAMM8PYvuAngvNo4IXgUgZcxIEaxjKIN9i2CCMZqCSKe2zH-yfOuRJRuMV6knM9DPlwm32c394LCA9n04fvt_fjDoKrr8_pYASPVBGs0FlsbV2dQoYVpAQIjaPcZq1dEZTonsmBqR14cssSxhcTwCoHbOrG1S3ZCs4EFLSiwkMnSiwImi6RqtbDq20XkNWurtCtYUHoWsitJ_S0yzYNFp72_rjPZleX09E4mNxd34zOJkEjlGiD3BidSpXknEgTqlxqhcoIg6RzE8pUowwxSqJUZxKl0YlODEcyUmQhoZR9dvSb29V9WZJv56X1GRUFVlQv_XzIYx6rOJJhZz34sy7TkvJ542y3fz3_f1P-AJDzd_o</recordid><startdate>201810</startdate><enddate>201810</enddate><creator>Akadam-Teker, Basak</creator><creator>Ozkara, Gulcin</creator><creator>Kurnaz-Gomleksiz, Ozlem</creator><creator>Bugra, Zehra</creator><creator>Teker, Erhan</creator><creator>Ozturk, Oguz</creator><creator>Yilmaz-Aydogan, Hulya</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9904-0146</orcidid><orcidid>https://orcid.org/0000-0002-8837-6664</orcidid><orcidid>https://orcid.org/0000-0002-0234-7548</orcidid><orcidid>https://orcid.org/0000-0002-4583-6890</orcidid><orcidid>https://orcid.org/0000-0001-9827-5253</orcidid><orcidid>https://orcid.org/0000-0003-3618-0560</orcidid><orcidid>https://orcid.org/0000-0002-2439-9269</orcidid></search><sort><creationdate>201810</creationdate><title>BMP1 5'UTR + 104 T/C gene variation: can be a predictive marker for serum HDL and apoprotein A1 levels in male patients with coronary heart disease</title><author>Akadam-Teker, Basak ; Ozkara, Gulcin ; Kurnaz-Gomleksiz, Ozlem ; Bugra, Zehra ; Teker, Erhan ; Ozturk, Oguz ; Yilmaz-Aydogan, Hulya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p141t-dff6b349d0ee6ea4d364a4f1fae6df53b6a35a797b6c3a3f6969f0aef31c5ea33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>5' Untranslated Regions - genetics</topic><topic>Alleles</topic><topic>Apolipoprotein A-I - analysis</topic><topic>Apolipoprotein A-I - blood</topic><topic>Apolipoprotein A-I - genetics</topic><topic>Biomarkers - blood</topic><topic>Bone Morphogenetic Protein 1 - blood</topic><topic>Bone Morphogenetic Protein 1 - genetics</topic><topic>Cholesterol, HDL - analysis</topic><topic>Cholesterol, HDL - blood</topic><topic>Coronary Disease - genetics</topic><topic>Gene Frequency - genetics</topic><topic>Genotype</topic><topic>Humans</topic><topic>Lipids - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akadam-Teker, Basak</creatorcontrib><creatorcontrib>Ozkara, Gulcin</creatorcontrib><creatorcontrib>Kurnaz-Gomleksiz, Ozlem</creatorcontrib><creatorcontrib>Bugra, Zehra</creatorcontrib><creatorcontrib>Teker, Erhan</creatorcontrib><creatorcontrib>Ozturk, Oguz</creatorcontrib><creatorcontrib>Yilmaz-Aydogan, Hulya</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular biology reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akadam-Teker, Basak</au><au>Ozkara, Gulcin</au><au>Kurnaz-Gomleksiz, Ozlem</au><au>Bugra, Zehra</au><au>Teker, Erhan</au><au>Ozturk, Oguz</au><au>Yilmaz-Aydogan, Hulya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>BMP1 5'UTR + 104 T/C gene variation: can be a predictive marker for serum HDL and apoprotein A1 levels in male patients with coronary heart disease</atitle><jtitle>Molecular biology reports</jtitle><addtitle>Mol Biol Rep</addtitle><date>2018-10</date><risdate>2018</risdate><volume>45</volume><issue>5</issue><spage>1269</spage><epage>1276</epage><pages>1269-1276</pages><eissn>1573-4978</eissn><abstract>Apolipoprotein A1 (Apo A1), the major protein of HDL, is secreted as a proprotein and then is cleaved by C-terminal procollagen endoproteinase/bone morphogenetic protein-1 (BMP1). BMP1 stimulates the conversion of newly secreted proapo A1 to its phospholipid-binding form. Therefore, genetic variations of BMP1 gene may affect serum ApoA1 and HDL levels. We aimed to investigate the effects of the functional 5'UTR + 104 (T/C) variant of BMP1 on serum ApoA1 and HDL levels and risk of coronary heart disease (CHD) in this study. The BMP1 5'UTR + 104 (T/C) (rs143383) variation was determined in 131 male patients with CHD and 51 male controls by real-time polymerase chain reaction technique. ApoA1 levels were measured by immunoturbidimetry. The serum Apo-A1 levels were found higher in controls with the BMP1-CC genotype than those with the T-allele (p < 0.001). Our findings show the association of this variation with serum ApoA1 and HDL-C levels which increase in the order of CT < TT < CC in the controls. No effect was found on ApoA1 and HDL-C levels in CHD patients, as it was observed in the controls. However, the BMP1-TT genotype was associated with higher triglyceride (TG) levels as compared to C-allele (p = 0.009). These discrepancies could be due to statin therapy which has dominant effects on lowering cholesterol levels comparing to TG levels. Our results indicated that the BMP1 5'UTR + 104 (T/C) variation may affect the serum ApoA1 and lipoprotein levels depending on statin therapy so that contributes to the development of CHD.</abstract><cop>Netherlands</cop><pmid>30062502</pmid><doi>10.1007/s11033-018-4283-8</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-9904-0146</orcidid><orcidid>https://orcid.org/0000-0002-8837-6664</orcidid><orcidid>https://orcid.org/0000-0002-0234-7548</orcidid><orcidid>https://orcid.org/0000-0002-4583-6890</orcidid><orcidid>https://orcid.org/0000-0001-9827-5253</orcidid><orcidid>https://orcid.org/0000-0003-3618-0560</orcidid><orcidid>https://orcid.org/0000-0002-2439-9269</orcidid></addata></record> |
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subjects | 5' Untranslated Regions - genetics Alleles Apolipoprotein A-I - analysis Apolipoprotein A-I - blood Apolipoprotein A-I - genetics Biomarkers - blood Bone Morphogenetic Protein 1 - blood Bone Morphogenetic Protein 1 - genetics Cholesterol, HDL - analysis Cholesterol, HDL - blood Coronary Disease - genetics Gene Frequency - genetics Genotype Humans Lipids - blood Male Middle Aged Polymorphism, Single Nucleotide - genetics Risk Factors |
title | BMP1 5'UTR + 104 T/C gene variation: can be a predictive marker for serum HDL and apoprotein A1 levels in male patients with coronary heart disease |
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