Restorative potentiality of S-allylcysteine against diabetic nephropathy through attenuation of oxidative stress and inflammation in streptozotocin–nicotinamide-induced diabetic rats

Aim In the present study, we evaluated the therapeutic potentiality of S -allylcysteine (SAC) in streptozotocin (STZ)–nicotinamide (NAD)-induced diabetic nephropathy (DN) in experimental rats. Methods SAC was orally administered for 45 days to rats with STZ–NAD-induced DN; a metformin-treated group...

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Veröffentlicht in:	European journal of nutrition 2019-09, Vol.58 (6), p.2425-2437
Hauptverfasser:	Sathibabu Uddandrao, V. V., Brahmanaidu, Parim, Ravindarnaik, Ramavat, Suresh, Pothani, Vadivukkarasi, S., Saravanan, Ganapathy
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorptiometry Animals Antidiabetics Antineoplastic Agents - pharmacology Antioxidants Antioxidants - pharmacology Biochemical markers Blood glucose Body composition Body weight Catalase Chemistry Chemistry and Materials Science Creatinine Cysteine - analogs & derivatives Cysteine - pharmacology Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - complications Diabetic Nephropathies - drug therapy Diabetic Nephropathies - etiology Diabetic nephropathy Disease Models, Animal Dual energy X-ray absorptiometry Electrical conductivity Glutathione peroxidase Hemoglobin Hyperglycemia Inflammation Inflammation - prevention & control Insulin Interleukin 6 Kidneys L-Lactate dehydrogenase Lactic acid Male mRNA Nephropathy Niacinamide Nutrition Original Contribution Oxidative stress Oxidative Stress - drug effects Polymerase chain reaction Rats Rats, Wistar Rodents Scanning electron microscopy Streptozocin Superoxide dismutase Tumor necrosis factor-TNF
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