CNS Efficacy of Osimertinib in Patients With T790M-Positive Advanced Non-Small-Cell Lung Cancer: Data From a Randomized Phase III Trial (AURA3)

Purpose In patients with epidermal growth factor receptor ( EGFR) mutation-positive advanced non-small-cell lung cancer (NSCLC), there is an unmet need for EGFR-tyrosine kinase inhibitors with improved CNS penetration and activity against CNS metastases, either at initial diagnosis or time of progre...

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Veröffentlicht in:	Journal of clinical oncology 2018-09, Vol.36 (26), p.2702-2709
Hauptverfasser:	Wu, Yi-Long, Ahn, Myung-Ju, Garassino, Marina Chiara, Han, Ji-Youn, Katakami, Nobuyuki, Kim, Hye Ryun, Hodge, Rachel, Kaur, Paramjit, Brown, Andrew P, Ghiorghiu, Dana, Papadimitrakopoulou, Vassiliki A, Mok, Tony S K
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylamides - therapeutic use Adult Aged Aged, 80 and over Aniline Compounds - therapeutic use Brain Neoplasms - drug therapy Brain Neoplasms - genetics Brain Neoplasms - secondary Carboplatin - therapeutic use Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - secondary Cisplatin - therapeutic use ErbB Receptors - genetics Female Humans Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - pathology Male Middle Aged Mutation Pemetrexed - therapeutic use Protein Kinase Inhibitors - therapeutic use Young Adult
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