Molecular and functional characterization of drug-metabolizing enzymes and transporter expression in the novel spontaneously immortalized human hepatocyte line HC-04

In toxicological research, immortalized human hepatocytes provide a useful alternative to primary hepatocytes because interindividual variability in the expression of drug-metabolizing enzymes and drug transporters can largely be eliminated. However, it is essential that the cell line retain the ori...

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Veröffentlicht in:	Toxicology in vitro 2007-12, Vol.21 (8), p.1390-1401
Hauptverfasser:	Lim, Priscilla L.K., Tan, Weiqi, Latchoumycandane, Calivarathan, Mok, Wei Chuen, Khoo, Yok Moi, Lee, How Sung, Sattabongkot, Jetsumon, Beerheide, Walter, Lim, Seng Gee, Tan, Theresa M.C., Boelsterli, Urs A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen - metabolism Analgesics, Non-Narcotic - metabolism Anti-Inflammatory Agents, Non-Steroidal - metabolism Antifibrinolytic Agents - metabolism Biomarkers Carrier Proteins - genetics Carrier Proteins - metabolism Cell Line Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism Diclofenac - metabolism Drug toxicity in vitro Drug transporters Drug-metabolizing enzymes Gene Expression Profiling Gene Expression Regulation Hepatocytes - metabolism Humans Immortalized human hepatocytes Vitamin K 3 - metabolism
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