Source of Endothelin-1 in Subarachnoid Hemorraghe
Endothelin-1 is the most potent vasoconstrictor known to date. This peptide is believed to play a pathophysiological role in the development of vasospasm, the most important complication of subarachnoid hemorrhage (SAH). In the present study we investigated the release of endothelin-1 in SAH and ana...
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| Veröffentlicht in: | Clinical chemistry and laboratory medicine 2001-04, Vol.39 (4), p.341-345 |
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| container_title | Clinical chemistry and laboratory medicine |
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| creator | Bertsch, Thomas Kuehl, Sandra Muehlhauser, Frank Walter, Silke Hodapp, Britta Rossol, Siegbert Schmeck, Joachim Ragoschke, Andreas Schütt, Sandra Fritzinger, Michael Horn, Peter Vajkoczy, Peter Wendel-Wellner, Martina Faßbender, Klaus |
| description | Endothelin-1 is the most potent vasoconstrictor known to date. This peptide is believed to play a pathophysiological role in the development of vasospasm, the most important complication of subarachnoid hemorrhage (SAH). In the present study we investigated the release of endothelin-1 in SAH and analyzed the cellular source of this peptide. At a protein and mRNA level we were able to show that endothelin-1 is produced by mononuclear leukocytes. Complementary in vitro studies revealed that aging and subsequent hemolysis of blood is sufficient to induce production of endothelin-1 by mononuclear leukocytes. Thus, cerebrospinal fluid-derived mononuclear leukocytes are a source of endothelin-1 in patients suffering from SAH. This finding may have important therapeutic implications as anti-leukocyte strategies could prevent cerebrovascular complications in SAH patients. |
| doi_str_mv | 10.1515/CCLM.2001.053 |
| format | Article |
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| title | Source of Endothelin-1 in Subarachnoid Hemorraghe |
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