Fine mapping and functional analysis of a common variant in MSMB on chromosome 10q11.2 associated with prostate cancer susceptibility

Two recent genome-wide association studies have independently identified a prostate cancer susceptibility locus on chromosome 10q11.2. The most significant single-nucleotide polymorphism (SNP) marker reported, rs10993994, is 57 bp centromeric of the first exon of the MSMB gene, which encodes β-micro...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-05, Vol.106 (19), p.7933-7938
Hauptverfasser:	Lou, Hong, Yeager, Meredith, Li, Hongchuan, Bosquet, Jesus Gonzalez, Hayes, Richard B, Orr, Nick, Yu, Kai, Hutchinson, Amy, Jacobs, Kevin B, Kraft, Peter, Wacholder, Sholom, Chatterjee, Nilanjan, Feigelson, Heather Spencer, Thun, Michael J, Diver, W. Ryan, Albanes, Demetrius, Virtamo, Jarmo, Weinstein, Stephanie, Ma, Jing, Gaziano, J. Michael, Stampfer, Meir, Schumacher, Fredrick R, Giovannucci, Edward, Cancel-Tassin, Geraldine, Cussenot, Olivier, Valeri, Antoine, Andriole, Gerald L, Crawford, E. David, Anderson, Stephen K, Tucker, Margaret, Hoover, Robert N, Fraumeni, Joseph F. Jr, Thomas, Gilles, Hunter, David J, Dean, Michael, Chanock, Stephen J
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Biological Sciences Cell Line, Tumor Cell lines chromosome 10 Chromosome Mapping Chromosomes Chromosomes, Human, Pair 10 Cyclic AMP response element-binding protein Cyclic AMP Response Element-Binding Protein - metabolism DNA Electrophoretic mobility Exons Gene expression Gene mapping Genes Genetic loci Genetic markers Genetic Predisposition to Disease Genetic research Genetic Variation Genome Genomics Genotypes Heterozygote Humans Male Medical genetics Messenger RNA Polymorphism, Genetic Polymorphism, Single Nucleotide Promoter regions Promoters Prostate Prostate cancer Prostatic Neoplasms - genetics Prostatic Secretory Proteins - genetics Prostatic Secretory Proteins - physiology Proteins Single-nucleotide polymorphism Susceptibility Transcription factors Tumor cell lines
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