Parthenolide, a Natural Inhibitor of Nuclear Factor-κB, Inhibits Lung Colonization of Murine Osteosarcoma Cells

Purpose: The transcription factor nuclear factor-κB (NF-κB) regulates the expression of several genes important for tumor metastasis and is constitutively active in the highly metastatic murine osteosarcoma cell line LM8. Parthenolide, a sesquiterpene lactone, was reported to inhibit the DNA binding...

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Veröffentlicht in:	Clinical cancer research 2007-01, Vol.13 (1), p.59-67
Hauptverfasser:	KISHIDA, Yuki, YOSHIKAWA, Hideki, MYOUI, Akira
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences Diseases of the osteoarticular system invasiveness Medical sciences metastasis nuclear factor-κB (NF-κB) parthenolide Pharmacology. Drug treatments Tumors of striated muscle and skeleton vascular endothelial growth factor (VEGF)
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