HIV‐1 drug resistance testing at second‐line regimen failure in Arua, Uganda: avoiding unnecessary switch to an empiric third‐line

Objectives The number of patients on second‐line antiretroviral therapy is growing, but data on HIV drug resistance patterns at failure in resource‐constrained settings are scarce. We aimed to describe drug resistance and investigate the factors associated with extensive resistance to nucleoside/nuc...

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Veröffentlicht in:	Tropical medicine & international health 2018-10, Vol.23 (10), p.1075-1083
Hauptverfasser:	Fily, F., Ayikobua, E., Ssemwanga, D., Nicholas, S., Kaleebu, P., Delaugerre, C., Pasquier, E., Amoros Quiles, I., Balkan, S., Schramm, B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anti-HIV Agents - therapeutic use Antiretroviral agents Antiretroviral drugs Antiretroviral therapy Antiretroviral Therapy, Highly Active - methods CD4 antigen Drug resistance Drug Resistance, Multiple, Viral Female GLP-1 receptor agonists HIV HIV Infections - drug therapy HIV Infections - virology HIV‐1 Human immunodeficiency virus Humans Integrase Logistic Models Male Medication Adherence Mutation Ouganda Patients Pharmacology Protease Protease inhibitors Proteinase inhibitors Resistance factors Reverse Transcriptase Inhibitors - therapeutic use Risk Factors RNA-directed DNA polymerase résistance aux médicaments second‐line antiretroviral therapy Switches Therapy traitement antirétroviral de seconde ligne Uganda VIH‐1 Viral Load - drug effects Young Adult
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