Fighting the oxidative assault: the Trypanosoma cruzi journey to infection
Activation of professional phagocytes with the concomitant generation of oxidant species is a medullar innate immune process for the control of acute Trypanosoma cruzi infection. Recent data reinforce the hypothesis that parasites more prepared to deal with the host-oxidative assault are more effici...
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| Veröffentlicht in: | Current opinion in microbiology 2009-08, Vol.12 (4), p.415-421 |
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| creator | Piacenza, Lucía Alvarez, María Noel Peluffo, Gonzalo Radi, Rafael |
| description | Activation of professional phagocytes with the concomitant generation of oxidant species is a medullar innate immune process for the control of acute Trypanosoma cruzi infection. Recent data reinforce the hypothesis that parasites more prepared to deal with the host-oxidative assault are more efficient for the establishment of Chagas disease. For instance, parasites overexpressing peroxiredoxins are more resistant to macrophage-derived peroxynitrite, a key cytotoxic oxidant produced in the phagosome towards the internalized parasite. Differentiation to the infective metacyclic trypomastigote is accompanied by an increased expression of antioxidant enzymes. Moreover, augmented antioxidant enzyme expression and activities correlate with higher parasite virulence in experimental infections. The potency of the parasite antioxidant armamentarium influences the final fate of the Trypanosoma cruzi journey to macrophage invasion at the onset of infection. |
| doi_str_mv | 10.1016/j.mib.2009.06.011 |
| format | Article |
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Psychology</subject><subject>Host-Parasite Interactions</subject><subject>Human protozoal diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Macrophages - immunology</subject><subject>Macrophages - parasitology</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Oxidants - immunology</subject><subject>Oxidants - metabolism</subject><subject>Oxidative Stress</subject><subject>Parasitic diseases</subject><subject>Pathology</subject><subject>Protozoal diseases</subject><subject>Stress, Physiological</subject><subject>Trypanosoma cruzi</subject><subject>Trypanosoma cruzi - immunology</subject><subject>Trypanosoma cruzi - physiology</subject><subject>Trypanosomiasis</subject><issn>1369-5274</issn><issn>1879-0364</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFu1DAQhi1ERUvhAbigXOCWdOx4nRikSqiiUFSJA-VsOc6knSWxFzupWJ4eb3cFEoeebFnfPx59P2OvOFQcuDpbVxN1lQDQFagKOH_CTnjb6BJqJZ_me610uRKNPGbPU1oDgNQr9Ywdc6240hpO2JdLur2byd8W8x0W4Rf1dqZ7LGxKdhnndw_PN3G7sT6kMNnCxeU3FeuwRI_bYg4F-QHdTMG_YEeDHRO-PJyn7Pvlx5uLz-X1109XFx-uSydVM5e2RWzsqmlbKZ3Q3VBzqflQC2iFdZ3Gune9UnKARg3KoZBaWie4gtr2Utn6lL3dz93E8HPBNJuJksNxtB7DkoyARufhOoN8D7oYUoo4mE2kycat4WB2As06RzuzE2hAmSwwZ14fhi_dhP2_xMFYBt4cAJucHYdovaP0lxO8lUJLkbn3ew6zinvCaJIj9A57itmX6QM9usb5f2k3kqf84Q_cYnrQnx0bbpIwYL7tmt4VDTqX3HJR_wEr8qLO</recordid><startdate>20090801</startdate><enddate>20090801</enddate><creator>Piacenza, Lucía</creator><creator>Alvarez, María Noel</creator><creator>Peluffo, Gonzalo</creator><creator>Radi, Rafael</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>M7N</scope></search><sort><creationdate>20090801</creationdate><title>Fighting the oxidative assault: the Trypanosoma cruzi journey to infection</title><author>Piacenza, Lucía ; Alvarez, María Noel ; Peluffo, Gonzalo ; Radi, Rafael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-a8ee7a578844c29bf31491f32082acb9e3dcd664f076f6ce2494ac21603ad46a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Chagas Disease - parasitology</topic><topic>Fundamental and applied biological sciences. 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| subjects | Animals Biological and medical sciences Chagas Disease - parasitology Fundamental and applied biological sciences. Psychology Host-Parasite Interactions Human protozoal diseases Humans Infectious diseases Macrophages - immunology Macrophages - parasitology Medical sciences Microbiology Oxidants - immunology Oxidants - metabolism Oxidative Stress Parasitic diseases Pathology Protozoal diseases Stress, Physiological Trypanosoma cruzi Trypanosoma cruzi - immunology Trypanosoma cruzi - physiology Trypanosomiasis |
| title | Fighting the oxidative assault: the Trypanosoma cruzi journey to infection |
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