A2144G Is the Main Mutation in the 23S rRNA Gene of Helicobacter pylori Associated with Clarithromycin Resistance
To detect point mutations A2115C, A2143G/C, and A2144G in the 23S rRNA gene of Helicobacter pylori associated with resistance of the microorganism to clarithromycin, a new powerful way of analysis was used. This method involved the reaction of minisequencing followed by MALDI-TOF mass spectrometry o...
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| Veröffentlicht in: | Russian journal of genetics 2005-10, Vol.41 (10), p.1095-1100 |
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| container_title | Russian journal of genetics |
| container_volume | 41 |
| creator | Momynaliev, K. T. Selezneva, O. V. Kozlova, A. A. Vereshchagin, V. A. Il'ina, E. N. Govorun, V. M. |
| description | To detect point mutations A2115C, A2143G/C, and A2144G in the 23S rRNA gene of Helicobacter pylori associated with resistance of the microorganism to clarithromycin, a new powerful way of analysis was used. This method involved the reaction of minisequencing followed by MALDI-TOF mass spectrometry of reaction products. In ten analyzed clarithromycin-resistant clinical isolates of H. pylori obtained in Russia, the resistance was found to be mediated only by mutation A2144G in the 23S rRNA gene. |
| doi_str_mv | 10.1007/s11177-005-0205-7 |
| format | Article |
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| ispartof | Russian journal of genetics, 2005-10, Vol.41 (10), p.1095-1100 |
| issn | 1022-7954 1608-3369 |
| language | eng |
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| source | SpringerLink Journals |
| subjects | Helicobacter pylori |
| title | A2144G Is the Main Mutation in the 23S rRNA Gene of Helicobacter pylori Associated with Clarithromycin Resistance |
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