TFF-2 inhibits iNOS/NO in monocytes, and nitrated protein in healing colon after colitis
Endogenous trefoil (TFF) peptides have reparative and anti-inflammatory actions in colitis because luminal application in vivo potently reduces inflammatory indices and accelerates healing. Since chronic production of NO via inducible nitric oxide synthase activity (iNOS) leads to tissue damage and...
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| Veröffentlicht in: | Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2004-05, Vol.25 (5), p.803-809 |
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| container_title | Peptides (New York, N.Y. : 1980) |
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| creator | Giraud, Andrew S Pereira, Prue M Thim, Lars Parker, Lorraine M Judd, Louise M |
| description | Endogenous trefoil (TFF) peptides have reparative and anti-inflammatory actions in colitis because luminal application in vivo potently reduces inflammatory indices and accelerates healing. Since chronic production of NO via inducible nitric oxide synthase activity (iNOS) leads to tissue damage and inflammation, we tested whether TFF2 could inhibit NO production in a monocyte cell line in response to bacterial endotoxin, and in vivo by measuring inflammatory indices and nitrated protein expression in rat colon after colitis induction. We showed that TFF2 can inhibit iNOS and NO in monocytes and inflammatory compartment size in vivo, and conclude that trefoils can regulate monocyte NO-mediated inflammation in colitis. |
| doi_str_mv | 10.1016/j.peptides.2004.01.019 |
| format | Article |
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Since chronic production of NO via inducible nitric oxide synthase activity (iNOS) leads to tissue damage and inflammation, we tested whether TFF2 could inhibit NO production in a monocyte cell line in response to bacterial endotoxin, and in vivo by measuring inflammatory indices and nitrated protein expression in rat colon after colitis induction. 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We showed that TFF2 can inhibit iNOS and NO in monocytes and inflammatory compartment size in vivo, and conclude that trefoils can regulate monocyte NO-mediated inflammation in colitis.</description><subject>Animals</subject><subject>Benzenesulfonates - toxicity</subject><subject>Cells, Cultured</subject><subject>Colitis</subject><subject>Colitis - chemically induced</subject><subject>Colitis - drug therapy</subject><subject>Colitis - pathology</subject><subject>Colon - metabolism</subject><subject>Colon - pathology</subject><subject>Inducible nitric oxide synthase</subject><subject>Macrophages - metabolism</subject><subject>Mucins - pharmacology</subject><subject>Muscle Proteins - pharmacology</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - metabolism</subject><subject>Nitric Oxide Synthase - antagonists & inhibitors</subject><subject>Nitric Oxide Synthase - metabolism</subject><subject>Peptides - pharmacology</subject><subject>Rats</subject><subject>Trefoil Factor-2</subject><subject>Trefoil peptide</subject><issn>0196-9781</issn><issn>1873-5169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMotlb_QtmTJ7dNsh_Z3JRiVZD2YAVvYTeZtSm7mzVJhf57s7TiUXhhhskzM5kXoSnBM4JJPt_Neui9VuBmFON0hkkQP0NjUrAkzkjOz9E4VPKYs4KM0JVzOxzAlBeXaEQywljBsjH62CyXMY10t9WV9i7Sq_XbfLUOhag1nZEHD-4uKjsVddrb0oOKems8hPegLZSN7j4jaRrTRWXtwQ659tpdo4u6bBzcnOIEvS8fN4vn-HX99LJ4eI1lwjMf05qxvKDhphqrlKu0wkVBUoUlrxUFSiqS1AkAlZViKclxXRDKKwqYKlCsTCbo9jg3fOtrD86LVjsJTVN2YPZOUMwGB_IA5kdQWuOchVr0VrelPQiCxeCp2IlfT8XgqcAkiIfG6WnDvmpB_bWdTAzA_RGAcOe3Biuc1NBJUNqC9EIZ_d-OHx5rixQ</recordid><startdate>20040501</startdate><enddate>20040501</enddate><creator>Giraud, Andrew S</creator><creator>Pereira, Prue M</creator><creator>Thim, Lars</creator><creator>Parker, Lorraine M</creator><creator>Judd, Louise M</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope></search><sort><creationdate>20040501</creationdate><title>TFF-2 inhibits iNOS/NO in monocytes, and nitrated protein in healing colon after colitis</title><author>Giraud, Andrew S ; Pereira, Prue M ; Thim, Lars ; Parker, Lorraine M ; Judd, Louise M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c395t-2f77682101f0d49d4b08814d0c9fd2e21b13f3ee2cbd74160f8129b2e02ded7a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Benzenesulfonates - toxicity</topic><topic>Cells, Cultured</topic><topic>Colitis</topic><topic>Colitis - chemically induced</topic><topic>Colitis - drug therapy</topic><topic>Colitis - pathology</topic><topic>Colon - metabolism</topic><topic>Colon - pathology</topic><topic>Inducible nitric oxide synthase</topic><topic>Macrophages - metabolism</topic><topic>Mucins - pharmacology</topic><topic>Muscle Proteins - pharmacology</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - metabolism</topic><topic>Nitric Oxide Synthase - antagonists & inhibitors</topic><topic>Nitric Oxide Synthase - metabolism</topic><topic>Peptides - pharmacology</topic><topic>Rats</topic><topic>Trefoil Factor-2</topic><topic>Trefoil peptide</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Giraud, Andrew S</creatorcontrib><creatorcontrib>Pereira, Prue M</creatorcontrib><creatorcontrib>Thim, Lars</creatorcontrib><creatorcontrib>Parker, Lorraine M</creatorcontrib><creatorcontrib>Judd, Louise M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Peptides (New York, N.Y. : 1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Giraud, Andrew S</au><au>Pereira, Prue M</au><au>Thim, Lars</au><au>Parker, Lorraine M</au><au>Judd, Louise M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>TFF-2 inhibits iNOS/NO in monocytes, and nitrated protein in healing colon after colitis</atitle><jtitle>Peptides (New York, N.Y. : 1980)</jtitle><addtitle>Peptides</addtitle><date>2004-05-01</date><risdate>2004</risdate><volume>25</volume><issue>5</issue><spage>803</spage><epage>809</epage><pages>803-809</pages><issn>0196-9781</issn><eissn>1873-5169</eissn><abstract>Endogenous trefoil (TFF) peptides have reparative and anti-inflammatory actions in colitis because luminal application in vivo potently reduces inflammatory indices and accelerates healing. 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| identifier | ISSN: 0196-9781 |
| ispartof | Peptides (New York, N.Y. : 1980), 2004-05, Vol.25 (5), p.803-809 |
| issn | 0196-9781 1873-5169 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Benzenesulfonates - toxicity Cells, Cultured Colitis Colitis - chemically induced Colitis - drug therapy Colitis - pathology Colon - metabolism Colon - pathology Inducible nitric oxide synthase Macrophages - metabolism Mucins - pharmacology Muscle Proteins - pharmacology Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - metabolism Peptides - pharmacology Rats Trefoil Factor-2 Trefoil peptide |
| title | TFF-2 inhibits iNOS/NO in monocytes, and nitrated protein in healing colon after colitis |
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