Selective Inhibition of FcεRI-Mediated Mast Cell Activation by a Truncated Variant of Cbl-b Related to the Rat Model of Type 1 Diabetes Mellitus

Ubiquitin-protein ligase Cbl-b negatively regulates high affinity IgE receptor (FcεRI)–mediated degranulation and cytokine gene transcription in mast cells. In this study, we have examined the role of a truncated variant of Cbl-b related to the rat model of type 1 diabetes mellitus using the mast ce...

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Veröffentlicht in:	Journal of biochemistry (Tokyo) 2005-06, Vol.137 (6), p.711-720
Hauptverfasser:	Qu, Xiujuan, Miah, S. M. Shahjahan, Hatani, Tomoko, Okazaki, Mami, Hori-Tamura, Naoko, Yamamura, Hirohei, Hotta, Hak, Sada, Kiyonao
Format:	Artikel
Sprache:	eng
Schlagworte:	FcεRI GEM glycolipid-enriched microdomain high affinity IgE receptor IDDM insulin-dependent diabetes mellitus lipid raft mast cells/basophils NFAT nuclear factor of activated T cells phosphotyrosine protein-tyrosine phosphorylation pTyr SH2 domain Src-homology-2 domain UBA domain ubiquitin-associated domain ubiquitin-protein ligase
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